Immediate toxicity during fractionated total body irradiation as conditioning for bone marrow transplantation

Buchali, A.; Feyer, Petra; Groll, Jens; Massenkeil, Gero; Arnold, Renate; Budach, Volker

doi:10.1016/s0167-8140(99)00178-4

Cited by 78 publications

(44 citation statements)

References 19 publications

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“…However, also fractionated TBI used as conditioning therapy can induce xerostomia. 37 Subjective reports of oral dryness obtained in a survey study among lymphoma patients after autologous HSCT (mean: 6 years after the therapy), reported xerostomia to be much more common in survivors who had received TBI as a part of their conditioning regimen in comparison with those without TBI. 38 In the current study, xerostomia was reported by 77% of the recipients but only by 9% of the donors.…”

Section: Discussionmentioning

confidence: 99%

Sicca symptoms and their impact on quality of life among very long-term survivors after hematopoietic SCT

Daikeler

Mauramo

Rovó

et al. 2013

Bone Marrow Transplant

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The objective of this prospective cross-sectional case-control study was to examine the prevalence of dryness symptoms and its impact on quality of life (QoL) among very long-term survivors after hematopoietic SCT (HSCT) in comparison with their respective sibling donors. Forty-four allogeneic HSCT recipients with a long-term survival (median: 17.5; range: 11-26 years) were included. Their respective, HLA-identical sibling donors served as controls. Clinical examinations included saliva flow rates (SFR) and the Schirmer's test. The presence of sicca symptoms of mouth, eyes and skin were inquired. The social functioning (SF)-36 questionnaire was applied. Recipients had lower (Po0.01) unstimulated and stimulated mean SFR than donors. Schirmer's test results o5 mm was found in 45% of the recipients in comparison with 27% of the donors (P ¼ 0.07). Xerostomia (34 vs 4 subjects), xerophtalmia (23 vs 3) and dry skin (32 vs 12) were reported more often by the recipients than donors (Po0.001). Sicca symptoms and their objective findings correlated with QoL. The mean SF-36 scores of the donors were significantly higher than those of the recipients for physical component summary. In conclusion, sicca symptoms are common amongst long-term survivors of HSCT and affect remarkably the QoL.

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Section: Discussionmentioning

confidence: 99%

Sicca symptoms and their impact on quality of life among very long-term survivors after hematopoietic SCT

Daikeler

Mauramo

Rovó

et al. 2013

Bone Marrow Transplant

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“…However, due to the high dose to both the bone marrow and normal healthy tissues, toxicities and treatment‐related mortalities are a significant concern 10, 11. Side effects from TBI can be extensive and include acute symptoms such as nausea and loss of appetite as well as infertility and secondary malignancies 12, 13…”

Section: Introductionmentioning

confidence: 99%

Energy‐dependent OAR sparing and dose conformity for total marrow irradiation of obese patients

Cherpak

Monajemi

Chytyk-Praznik

et al. 2018

J Applied Clin Med Phys

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PurposeTo investigate the effect on target coverage and organs at risk sparing by using 10 versus 6 MV for VMAT total marrow irradiation of obese patients.Methods and MaterialsTwenty‐six total marrow irradiation, TMI, treatment plans delivered between December 2014 and June 2017 were reviewed and 10 were chosen for replanning based on patient characteristics and plan metrics. Beam geometry and isocenter placement were conserved, energy was changed from 6 to 10 MV and plans were reoptimized. Resulting dose distributions were compared to original plans to evaluate any potential advantage of choosing one energy over the other.ResultsTarget coverage and total monitor units were consistent between the 6 and 10 MV plans when averaged over all ten patients. Improvement in the conformity index (−11.0%, P = 0.009) when using 10 MV was statistically significant compared to the 6 MV plans. Volumes of normal tissue receiving 50%, 75%, and 90% Rx all decreased for the 10 MV plans compared to the original 6 MV plans. The mean dose to individual OARs decreased significantly for all investigated structures except for the lenses, oral cavity, and genitalia. The largest decreases in Dmean were found for the rectum (22.4%, P = 0.004) and bladder (18.1%, P = 0.005). The three highest priorities for sparing during plan optimization (lungs, liver, and heart), showed decreases of 7.6%, 16.1%, and 13.0%.ConclusionsUse of a higher energy 10 MV beam provided similar dose to target while achieving increased OAR and normal tissue sparing for the patients reviewed in this study.

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“…Tek fraksiyonda 8-10 Gy verildiğinde bulantı, kusma ve ishal en sık görülen akut yan etkilerdir [20][21][22] . Bu etkiler TVI öncesi verilen sitotoksik ajanlara da bağlı olabilir.…”

Section: Tvi Yan Etkileri Akut Toksisiteunclassified

“…Bu etkiler TVI öncesi verilen sitotoksik ajanlara da bağlı olabilir. Fraksiyone ya da düşük doz hızlı TVI bu ve diğer yan etkilerin insidansını ve ciddiyetini azaltır 21,23 . Hastalarda ayrıca 10 gün içinde ağız kuruluğu, gözyaşında azalma, oral ve özefagial mukozit görülür.…”

Section: Tvi Yan Etkileri Akut Toksisiteunclassified

Hematopoetik kök hücre naklinde tüm vücut ışınlama

Andiç¹

2014

Arşiv Kaynak Tarama Dergisi

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Total body irradiation is used in conjunction with chemotherapy as a conditioning regimen in the treatment of many disease such as leukemia, myelodysplastic syndrome, aplastic anemia, multiple myeloma and lymphoma prior to the hematopoetic stem cell transplantation. The main purposes of the hematopoetic stem cell transplantation are eradication of the recipient bone marrow and any residual cancer cells, creation of space in the receipient bone marrow for donor hematopoetic stem cells, and immunosuppression to prevent rejection of donor stem cells in the case of an allotransplant.

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Immediate toxicity during fractionated total body irradiation as conditioning for bone marrow transplantation

Cited by 78 publications

References 19 publications

Sicca symptoms and their impact on quality of life among very long-term survivors after hematopoietic SCT

Sicca symptoms and their impact on quality of life among very long-term survivors after hematopoietic SCT

Energy‐dependent OAR sparing and dose conformity for total marrow irradiation of obese patients

Hematopoetik kök hücre naklinde tüm vücut ışınlama

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