IMMOBILIZATION HYPERCALCEMIA AFTER SINGLE LIMB FRACTURES IN CHILDREN & ADOLESCENTS

Abstract

To ascertain cerebral metabolic responses to hypoglycemia with superimposed hypoxia, newborn rats were given regular insulin (30 u/kg 6.c.).Animals were observed for up to 2 hrs with no ill effects, inspite of blood glucose concentrations of 0.75 W 1 . When exposed to 100% N2 at 370C. these animals survive only 1/10 as long as littermate controls with normal blood glucose levels .. - bill, decreased h t h agei12-15, and increased wi& ages 16r18.Cholesterol in low-density lipoprotein (LDL) paralleled the SC trend (Fig. 1). The increase of SC from lower-decile to higherdecile children was due mostly to increase of the LDL fraction ( Concentrations in urine of cyclic-AMP and serum levels of both parathyroid hormone and 25-hydroxyvitamin D were within normal range. 2 patients with Cai+ in serum 2 6.00mg/dl were treated with salmon calcitonin. The combination of salmon calcitonin therapy, and as rapid mobilization as possible, produced prompt resolution of the biochemical abnormalities. C R O T O N A S E DEFICIENCY: D E M O N S T R A T I O N O FThese data indicate that: 1) Immobilization hypercalcemia commonly occurs in both children and adolescents; 2) Single limb fracture of a weight bearing bone is sufficient to produce it;and 3) Frequent measurements of 24h urine collections for calcium/ creatinine ratios represents a reliable laboratory method for monitoring such patients.