Immune and stem cell compartments of acetabular and femoral bone marrow in hip osteoarthritis patients

Trivanović, Drenka; Harder, Janek; Leucht, Maximilian; Kreuzahler, Theresa; Schlierf, Bianca; Holzapfel, Boris Michael; Rudert, Maximilian; Jakob, Franz; Herrmann, Marietta

doi:10.1016/j.joca.2022.05.001

Cited by 7 publications

(4 citation statements)

References 51 publications

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“…It might be that the DDH-OA Ac samples were obtained from an anatomically similar location, but not a biomechanically similar location, as the pOA Ac samples were. A study comparing Ac MSPCs and Fh MSPCs of pOA patients, as well as our study, found significant differences between these populations, advocating location-specific composition of MSPCs [31]. Therefore, these morphological changes also may be due to a possible different pathogenesis of OA in the Ac compared to the Fh or perhaps a "shift in the time points" in various locations of the progression of the disease itself.…”

Section: Discussionsupporting

confidence: 74%

“…Trivanović et al also found a higher proportion of CD271+ MSPCs in the pOA Fh compared to the Ac [31]. Moreover, Ac MSPCs showed osteogenic and chondrogenic potential, but their adipogenic capacity was lower compared to the Fh MSPCs [31]. Kuci et al showed that CD271+ cells have a higher degree of adipogenic capacity compared to non-selected MSPCs [47].…”

Section: Discussionmentioning

confidence: 96%

“…They showed that MSPCs from the Ac have a greater ability to form colonies, while MSPCs from the Fh have a more pronounced osteogenic potential compared to MSPCs from the Ac [46]. Trivanović et al also found a higher proportion of CD271+ MSPCs in the pOA Fh compared to the Ac [31]. Moreover, Ac MSPCs showed osteogenic and chondrogenic potential, but their adipogenic capacity was lower compared to the Fh MSPCs [31].…”

Section: Discussionmentioning

confidence: 99%

“…Kuci et al showed that CD271+ cells have a higher degree of adipogenic capacity compared to non-selected MSPCs [47]. Trivanović et al hypothesize that the Ac and Fh in pOA host distinct mesenchymal cell phenotypes [31]. Barilani et al state that the CD271+ subpopulation seems to be heterogeneous, confirming the need for more specific markers to define MSPCs and their properties [41].…”

Section: Discussionmentioning

confidence: 99%

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Distinctiveness of Femoral and Acetabular Mesenchymal Stem and Progenitor Populations in Patients with Primary and Secondary Hip Osteoarthritis Due to Developmental Dysplasia

Plečko,

Kovačić,

Grčević

et al. 2024

IJMS

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Primary hip osteoarthritis (pOA) develops without an apparent underlying reason, whereas secondary osteoarthritis arises due to a known cause, such as developmental dysplasia of the hips (DDH-OA). DDH-OA patients undergo total hip arthroplasty at a much younger age than pOA patients (50.58 vs. 65 years in this study). Recently, mesenchymal stem and progenitor cells (MSPCs) have been investigated for the treatment of osteoarthritis due to their immunomodulatory and regenerative potential. This study identified cells in subchondral bone expressing common MSPC markers (CD10, CD73, CD140b, CD146, CD164, CD271, GD2, PDPN) in vivo and compared the proportions of these populations in pOA vs. DDH-OA, further correlating them with clinical, demographic, and morphological characteristics. The differences in subchondral morphology and proportions of non-hematopoietic cells expressing MSPC markers were noted depending on OA type and skeletal location. Bone sclerosis was more prominent in the pOA acetabulum (Ac) in comparison to the DDH-OA Ac and in the pOA Ac compared to the pOA femoral head (Fh). Immunophenotyping indicated diagnosis-specific differences, such as a higher proportion of CD164+ cells and their subsets in DDH-OA, while pOA contained a significantly higher proportion of CD10+ and GD2+ cells and subsets, with CD271+ being marginally higher. Location-specific differences showed that CD271+ cells were more abundant in the Fh compared to the Ac in DDH-OA patients. Furthermore, immunohistochemical characterization of stromal bone-adjacent cells expressing MSPC markers (CD10, CD164, CD271, GD2) in the Ac and Fh compartments was performed. This research proved that immunophenotype profiles and morphological changes are both location- and disease-specific. Furthermore, it provided potentially effective targets for therapeutic strategies. Future research should analyze the differentiation potential of subsets identified in this study. After proper characterization, they can be selectively targeted, thus enhancing personalized medicine approaches in joint disease management.

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Section: Discussionsupporting

confidence: 74%