Immune cells and bone: coupling goes both ways

Horwood, Nicole J.

doi:10.3109/08820139.2013.822762

Cited by 6 publications

(5 citation statements)

References 102 publications

(108 reference statements)

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“…In addition to osteoblasts and osteocytes, activated T cells, B cells, NK cells, fibroblasts, and thymus cells can also produce RANKL. Apart from osteoclasts and their progenitor cells, dendritic cells also express RANK ( 42 ). Previous studies suggested that osteoblasts were the main source of OPG.…”

Section: Osteoimmunology: Interaction Between the Skeletal And Immunementioning

confidence: 99%

Interferon-Gamma-Mediated Osteoimmunology

et al. 2018

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Osteoimmunology is the interdiscipline that focuses on the relationship between the skeletal and immune systems. They are interconnected by shared signal pathways and cytokines. Interferon-gamma (IFN-γ) plays important roles in immune responses and bone metabolism. IFN-γ enhances macrophage activation and antigen presentation. It regulates antiviral and antibacterial immunity as well as signal transduction. IFN-γ can promote osteoblast differentiation and inhibit bone marrow adipocyte formation. IFN-γ plays dual role in osteoclasts depending on its stage. Furthermore, IFN-γ is an important pathogenetic factor in some immune-mediated bone diseases including rheumatoid arthritis, postmenopausal osteoporosis, and acquired immunodeficiency syndrome. This review will discuss the contradictory findings of IFN-γ in osteoimmunology and its clinical application potential.

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Section: Osteoimmunology: Interaction Between the Skeletal And Immunementioning

confidence: 99%

Interferon-Gamma-Mediated Osteoimmunology

et al. 2018

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“…The ability of macrophages to phagocytose endows them with a variety of tissue‐specific trophic roles. Osteoclasts, for example, are bone‐resident macrophages that destroy senescent bone cells and, as such, regulate bone morphogenesis . Metchnikoff also performed the first intravital imaging of macrophages, taking advantage of the transparency of starfish larvae.…”

Section: Introductionmentioning

confidence: 99%

The role of lymph node sinus macrophages in host defense

Kuka

Iannacone

2014

Annals of the New York Academy of Sciences

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Strategically positioned along lymphatic vessels, lymph nodes act as filter stations preventing systemic pathogen dissemination; they are primary sites of innate immune responses and provide the staging grounds for the generation of adaptive immunity. Critical mediators of these lymph node functions are two phenotypically and functionally distinct subsets of macrophages: the subcapsular sinus macrophages and the medullary macrophages. This review focuses on the phenotype and function of these lymph node sinus-resident macrophages and summarizes methods for their proper identification and experimental manipulation.

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“…144 Collective data suggest that early uNK cells along with monocytes and trophoblasts are major sources of ANGPTs to regulate decidual spiral artery modeling and normal placentation. 145,146 ANGPT1 and ANGPT2 are detected in human uNK cell culture supernatants and both are at lower levels in second than in first trimester samples. 57 Increases in ANGPT1, ANGPT2 and IFNG (at 10 ng/ml level) are proposed to disrupt human vascular smooth muscle cells and breakdown extracellular matrix components 63 to enhance early angiogenesis.…”

Section: Angpt1/2mentioning

confidence: 99%

Leukocyte driven-decidual angiogenesis in early pregnancy

et al. 2014

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Successful pregnancy and long-term, post-natal maternal and offspring cardiac, vascular and metabolic health require key maternal cardiovascular adaptations over gestation. Within the pregnant decidualizing uterus, coordinated vascular, immunological and stromal cell changes occur. Considerable attention has been given to the roles of uterine natural killer (uNK) cells in initiating decidual spiral arterial remodeling, a process normally completed by mid-gestation in mice and in humans. However, leukocyte roles in much earlier, region specific, decidual vascular remodeling are now being defined. Interest in immune cell-promoted vascular remodeling is driven by vascular aberrations that are reported in human gestational complications such as infertility, recurrent spontaneous abortion, preeclampsia (PE) and fetal growth restriction. Appropriate maternal cardiovascular responses during pregnancy protect mothers and their children from later cardiovascular disease risk elevation. One of the earliest uterine responses to pregnancy in species with hemochorial placentation is stromal cell decidualization, which creates unique niches for angiogenesis and leukocyte recruitment. In early decidua basalis, the aspect of the implantation site that will cradle the developing placenta and provide the major blood vessels to support mature placental functions, leukocytes are greatly enriched and display specialized properties. UNK cells, the most abundant leukocyte subset in early decidua basalis, have angiogenic abilities and are essential for normal early decidual angiogenesis. The regulation of uNK cells and their roles in determining maternal and progeny cardiovascular health over pregnancy and postpartum are discussed.

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Immune cells and bone: coupling goes both ways

Cited by 6 publications

References 102 publications

Interferon-Gamma-Mediated Osteoimmunology

Interferon-Gamma-Mediated Osteoimmunology

The role of lymph node sinus macrophages in host defense

Leukocyte driven-decidual angiogenesis in early pregnancy

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