Immune Changes in Alcohol-Dependent Patients Without Medical Disorders

Schleifer, Steven J.; Keller, Steven E.; Shiflett, Samuel C.; Benton, Tonya; Eckholdt, Haftan

doi:10.1097/00000374-199907000-00009

Cited by 9 publications

(19 citation statements)

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“…Schleifer and colleagues (1999), however, did not find such differences in alcohol-dependant adults without medical disorders compared to non-abusing controls. Follow-on work by Schleifer and colleagues (2002), which included alcohol-dependent adults with minor health abnormalities, also found no differences in CD8+ and other immune measures.…”

Section: Discussioncontrasting

confidence: 64%

Lymphocyte measures in treatment-naïve 13–15-year old adolescents with alcohol use disorders

Naudé

Bouic²,

Senekal

et al. 2011

Alcohol

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Many adolescents have chronic exposure to hazardous levels of alcohol. This is likely to be a significant predictor of health outcomes, including those related to immunity. We assessed substance use and biochemical immunological parameters in heavy drinking adolescents (meeting DSM-IV criteria for alcohol dependence) and light/non-drinking control adolescents in Cape Town. Lifetime alcohol dose, measured in standard units of alcohol, was orders of magnitude higher in alcohol dependent (AD) participants than controls. All adolescent AD had a ‘weekends-only’ style of alcohol consumption. The AD group was chosen to represent relatively ‘pure’ AD, with minimal other drug use and no psychiatric diagnoses. With these narrow parameters in place, we found that AD adolescents were lymphopenic compared to controls, with significantly lower mean numbers of absolute circulating CD3+, CD4+ and CD8+ T-lymphocytes. Upon conclusion, we found that adolescent AD individuals with excessive alcohol intake, in a weekend binge-drinking style but without comorbid drug or psychiatric disorders, may be at increased risk of lymphopenia. This alcohol misuse may increase infectious disease susceptibility (including TB and HIV) by reducing immune system capabilities. Complex interactions of alcohol with other documented high-risk activities may further compound health risks.

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Section: Discussioncontrasting

confidence: 64%

Lymphocyte measures in treatment-naïve 13–15-year old adolescents with alcohol use disorders

Naudé

Bouic²,

Senekal

et al. 2011

Alcohol

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“…7,8 Alcohol is also known, however, to affect patients' immune system, and patients who have developed liver disease have different immunological behaviour than patients who misuse alcohol but have normal liver function. 19 There may therefore be an immunological mechanism underpinning excess alcohol consumption in psoriasis.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of psoriasis in patients with alcoholic liver disease

Tobin¹,

Higgins²,

Norris³

et al. 2009

Clinical and Experimental Dermatology

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“…As with other consequences of alcohol exposure (Hoek et al, 2005; Bravo et al, 2012), there appear to be gender differences in alcohol’s effects on phagocytic function. For example, Schleifer et al, (1999) found decreased phagocytosis in alcohol-dependent males, but not in females. There is some evidence that alcohol’s effects also differ among the phagocytic cells (Schleifer et al, 1999).…”

Section: Psychoneuroimmunological Analysis Of Substance Use Disordersmentioning

confidence: 98%

“…For example, Schleifer et al, (1999) found decreased phagocytosis in alcohol-dependent males, but not in females. There is some evidence that alcohol’s effects also differ among the phagocytic cells (Schleifer et al, 1999). In a study of predominately male participants, phagocytosis was evaluated and investigators found that the presence of an AUD affected polymorphonuclear neutrophils (PMNs) preferentially (Parlesak et al, 2003).…”

Section: Psychoneuroimmunological Analysis Of Substance Use Disordersmentioning

confidence: 98%

Substance use disorders: Psychoneuroimmunological mechanisms and new targets for therapy

Loftis

Huckans

2013

Pharmacology & Therapeutics

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An estimated 76.4 million people worldwide meet criteria for alcohol use disorders, and 15.3 million meet criteria for drug use disorders. Given the high rates of addiction and the associated health, economic, and social costs, it is essential to develop a thorough understanding of the impact of substance abuse on mental and physical health outcomes and to identify new treatment approaches for substance use disorders (SUDs). Psychoneuroimmunology is a rapidly expanding, multidisciplinary area of research that may be of particular importance to addiction medicine, as its focus is on the dynamic and complex interactions among behavioral factors, the central nervous system, and the endocrine and immune systems (Ader, 2001). This review, therefore, focuses on: 1) the psychoneuroimmunologic effects of SUDs by substance type and use pattern, and 2) the current and future treatment strategies, including barriers that can impede successful recovery outcomes. Evidence-based psychosocial and pharmacotherapeutic treatments are reviewed. Psychological factors and central nervous system correlates that impact treatment adherence and response are discussed. Several novel therapeutic approaches that are currently under investigation are introduced; translational data from animal and human studies is presented, highlighting immunotherapy as a promising new direction for addiction medicine.

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Immune Changes in Alcohol-Dependent Patients Without Medical Disorders

Abstract: The findings suggest that although males with chronic alcohol dependence have compromised phagocytic function, chronic alcohol-dependent subjects who are free of medical disorders do not have substantial abnormalities in many immune system functions.

Cited by 9 publications

References 0 publications

Lymphocyte measures in treatment-naïve 13–15-year old adolescents with alcohol use disorders

Lymphocyte measures in treatment-naïve 13–15-year old adolescents with alcohol use disorders

Prevalence of psoriasis in patients with alcoholic liver disease

Substance use disorders: Psychoneuroimmunological mechanisms and new targets for therapy

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