Immune changes in peripheral blood and hematoma of patients with intracerebral hemorrhage

Jiang, Chao; Wang, Yali; Hu, Qiangfu; Shou, Jixin; Zhu, Li; Tian, Na; Sun, Lu Xuan Lisa; Luo, Huan; Zuo, Fang; Li, Fangfang; Wang, Yingying; Zhang, Jing; Wang, Jiarui; Wang, Jian; Zhang, Jiewen

doi:10.1096/fj.201902478r

Cited by 57 publications

(47 citation statements)

References 94 publications

(303 reference statements)

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“…Relevant evidence indicated that the peripheral cellular immune system changed dramatically in the immediate aftermath of ICH (23). Therefore, changes in specific inflammatory markers in the peripheral blood are an indicator of the severity of the primary injury, theoretically.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Admission Systemic Inflammation Response Index in Patients With Spontaneous Intracerebral Hemorrhage: A Propensity Score Matching Analysis

Yuan

Liao³

et al. 2021

Front. Neurol.

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Intracerebral hemorrhage (ICH) accounts for ~15% of all strokes and is associated with high mortality and disability rates. The systemic inflammation response index (SIRI) is a novel systemic inflammatory marker based on peripheral neutrophil, monocyte, and lymphocyte counts. This study aimed to evaluate the prognostic significance of admission SIRI in patients with spontaneous ICH and compare its predictive ability with that of the neutrophil-to-lymphocyte ratio (NLR). This retrospective study was conducted based on a prospectively collected database of patients with ICH between June 2016 and January 2019. Propensity score matching (PSM) was conducted to adjust for potential imbalances in the clinical parameters. A total of 403 patients were included in the original cohort. The optimal SIRI cut-off value was 2.76. After 1:1 PSM based on potential confounding variables, a new cohort containing 262 patients was established for further analysis. In the original cohort, SIRI served as an independent predictor of 3-month functional outcome [odds ratio (OR), 1.302; 95% CI, 1.120–1.512; p = 0.001] and 1-month mortality (OR, 1.072; 95% CI, 1.020–1.126; p = 0.006), while NLR was independently associated with only 3-month functional outcomes (OR, 1.051; 95% CI, 1.004–1.100; p = 0.031) and not 1-month mortality. The same applied to the PSM cohort. Receiver operating characteristic analyses and predictive models indicated that in most instances, SIRI was superior to NLR and their components in predicting the outcomes of patients with ICH. Our study found that SIRI is determined to be an independent predictive indicator for ICH patients in 3-month functional outcomes and 1-month mortality. The prognostic predictive ability of SIRI was stronger than that of NLR.

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Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Admission Systemic Inflammation Response Index in Patients With Spontaneous Intracerebral Hemorrhage: A Propensity Score Matching Analysis

Yuan

Liao³

et al. 2021

Front. Neurol.

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“…In brain parenchyma, M1 microglia are the major source of inflammatory mediators, such as IL-1β, IL-6, IL-12, IL-23, and TNF-α (Jiang et al, 2020 ). Although inflammation is essential for innate immunity, it is the chief culprit to the sustained neurological deterioration in a sterile environment (Zhu et al, 2019 ).…”

Section: Functions Of Activated Microglia After Ichmentioning

confidence: 99%

Microglia Phenotype and Intracerebral Hemorrhage: A Balance of Yin and Yang

Fang

You

et al. 2021

Front. Cell. Neurosci.

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Intracerebral hemorrhage (ICH) features extremely high rates of morbidity and mortality, with no specific and effective therapy. And local inflammation caused by the over-activated immune cells seriously damages the recovery of neurological function after ICH. Fortunately, immune intervention to microglia has provided new methods and ideas for ICH treatment. Microglia, as the resident immune cells in the brain, play vital roles in both tissue damage and repair processes after ICH. The perihematomal activated microglia not only arouse acute inflammatory responses, oxidative stress, excitotoxicity, and cytotoxicity to cause neuron death, but also show another phenotype that inhibit inflammation, clear hematoma and promote tissue regeneration. The proportion of microglia phenotypes determines the progression of brain tissue damage or repair after ICH. Therefore, microglia may be a promising and imperative therapeutic target for ICH. In this review, we discuss the dual functions of microglia in the brain after an ICH from immunological perspective, elaborate on the activation mechanism of perihematomal microglia, and summarize related therapeutic drugs researches.

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“…Both preclinical and clinical studies suggest that microglia/macrophage-mediated inflammatory response plays an important role in hemorrhage-induced brain damage [ 64 , 65 ]. ICH results in very profound activation of microglia/macrophages, highly plastic cells, which display diverse phenotypes [ 66 ].…”

Section: Microrna and Ich-induced Neuroinflammationmentioning

confidence: 99%

Dysregulation of microRNA and Intracerebral Hemorrhage: Roles in Neuroinflammation

Kashif

Shah

Sukumari‐Ramesh

2021

IJMS

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Intracerebral hemorrhage (ICH) is a major public health problem and devastating subtype of stroke with high morbidity and mortality. Notably, there is no effective treatment for ICH. Neuroinflammation, a pathological hallmark of ICH, contributes to both brain injury and repair and hence, it is regarded as a potential target for therapeutic intervention. Recent studies document that microRNAs, small non-coding RNA molecules, can regulate inflammatory brain response after ICH and are viable molecular targets to alter brain function. Therefore, there is an escalating interest in studying the role of microRNAs in the pathophysiology of ICH. Herein, we provide, for the first time, an overview of the microRNAs that play roles in ICH-induced neuroinflammation and identify the critical knowledge gap in the field, as it would help design future studies.

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Immune changes in peripheral blood and hematoma of patients with intracerebral hemorrhage

Cited by 57 publications

References 94 publications

Prognostic Significance of Admission Systemic Inflammation Response Index in Patients With Spontaneous Intracerebral Hemorrhage: A Propensity Score Matching Analysis

Prognostic Significance of Admission Systemic Inflammation Response Index in Patients With Spontaneous Intracerebral Hemorrhage: A Propensity Score Matching Analysis

Microglia Phenotype and Intracerebral Hemorrhage: A Balance of Yin and Yang

Dysregulation of microRNA and Intracerebral Hemorrhage: Roles in Neuroinflammation

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