Immune-complex-trapping cells in the spleen of the oriental fire-bellied toad, Bombina orientalis

Dulak, Józef; Bauer, Jan; Ea, Döpp; N, van Rooijen

doi:10.1007/bf00297553

Cell Tissue Res

1993

DOI: 10.1007/bf00297553

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Immune-complex-trapping cells in the spleen of the oriental fire-bellied toad, Bombina orientalis

Józef Dulak

Jan Bauer

Döpp Ea

et al.

Abstract: The spleen of the oriental fire-bellied toad, Bombina orientalis, consists of well-developed white pulp, separated from the lymphocytic marginal zone by the connective tissue boundary layer. Injection of peroxidase-conjugated rabbit anti-peroxidase revealed that these immune complexes were localized on the surface of acid-phosphatase-positive and non-specific-esterase-positive cells in the white pulp. The majority of immune-complex-trapping cells were present around the blood vessels. Cell processes of some of… Show more

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Cited by 3 publications

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Histopathological analysis of carbaryl-induced toxicity in the spleen of Levantine frog, Pelophylax bedriagae (Anura: Ranidae)

Çakıcı

2018

Environ Sci Pollut Res

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This study describes the histopathological effects of carbaryl in the spleen of Levantine frog, Pelophylax bedriage. Due to its primary role in immune system, it is important to research the toxic effects of pesticides, which play an important role in environmental pollution, on spleen. To that end, adult frogs were exposed to carbaryl for 96 h. Experimental groups contained low dose, (0.05 mg/g), medium dose (0.1 mg/g) and high dose (0.2 mg/g). After following exposure to carbaryl, the frogs were euthanised and dissected. In low-dose group, there were no important changes in spleen tissue. In medium-dose group, prominence in haemorrhage just below the capsule and an increase in the melanomacrophage number were determined. In high-dose group, in addition to increases in the melanomacrophages, separations in capsule, haemorrhage below capsule and within splenic tissue, sinusoidal enlargement, congestion in dilated sinusoid, hypertrophic plasma cells and fibrosis were determined as important histological lesions in exposed frogs. This study clearly showed that carbaryl caused important histopathological damages in splenic tissue of Pelophylax bedriagae. In view of these findings, it can be said that this insecticide has the capacity to disrupt spleen' functions.

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Histopathological analysis of carbaryl-induced toxicity in the spleen of Levantine frog, Pelophylax bedriagae (Anura: Ranidae)

Çakıcı

2018

Environ Sci Pollut Res

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The amphibian's spleen as a source of biomarkers for ecotoxicity assessment: Historical review and trends

Tsukada,

Rodrigues,

Jacintho

et al. 2023

Science of The Total Environment

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The Phylogeny of the Spleen

Udroiu¹,

Sgura²

2017

The Quarterly Review of Biology

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The spleen can exert different functions: hematopoiesis, immune response, blood filtration, and blood storage. Presence and importance of each function vary among different species and, within a single species, vary during ontogeny. During the course of evolution, loss of hematopoietic functions was accompanied by increased specialization of other functions. Increase in the complexity of immunological features can be seen in the passage from scattered lymphocytes to segregation of the white pulp, organization of T- and B-lymphocyte regions and, finally, appearance of germinal centers. The red pulp remained essentially the same in all nonmammalian vertebrates, with a microarchitecture that concentrates blood and allows its filtration. In our view, this high splenic hematocrit was eventually co-opted in teleosts and mammals to develop a new function: the storage of red blood cells. Finally, mammalian species evolved different features of the red pulp, increasing the specialization of the filtration function (pulp sinuses) and/or storing function (muscularization)

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Immune-complex-trapping cells in the spleen of the oriental fire-bellied toad, Bombina orientalis

Cited by 3 publications

References 10 publications

Histopathological analysis of carbaryl-induced toxicity in the spleen of Levantine frog, Pelophylax bedriagae (Anura: Ranidae)

Histopathological analysis of carbaryl-induced toxicity in the spleen of Levantine frog, Pelophylax bedriagae (Anura: Ranidae)

The amphibian's spleen as a source of biomarkers for ecotoxicity assessment: Historical review and trends

The Phylogeny of the Spleen

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