Immune Complexes in the Middle Ear Fluid and Adenoid Tissue in Chronic Secretory Otitis Media

Palva, Tauno; Lehtinen, Tessa; Virtanen, Heikki

doi:10.3109/00016488309139439

Cited by 29 publications

(10 citation statements)

References 12 publications

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“…Several previous studies have explored the microbiology of the adenoids. 5,9,[12][13][14][15][16] However, most of these studies did not evaluate the role of anaerobic bacteria or did not use methods adequate for their optimal recovery. 5,[12][13][14][15][16] Furthermore, only one previous study included a group of healthy control subjects.…”

Section: Introductionmentioning

confidence: 99%

“…5,9,[12][13][14][15][16] However, most of these studies did not evaluate the role of anaerobic bacteria or did not use methods adequate for their optimal recovery. 5,[12][13][14][15][16] Furthermore, only one previous study included a group of healthy control subjects. 16 This study compared the qualitative and quantitative microbiology of core adenoid tissues from four groups of children: those with recurrent otitis media (ROM), recurrent adenotonsillitis (RAT), obstructive adenoid hypertrophy (OAH), and healthy control subjects.…”

Section: Introductionmentioning

confidence: 99%

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Microbiology of Healthy and Diseased Adenoids

2000

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Objective: To determine the qualitative and quantitative microbiology of core adenoid tissue obtained from four groups of 15 children each, with recurrent otitis media (ROM), recurrent adenotonsillitis (RAT), obstructive adenoid hypertrophy (OAH), and occlusion or speech abnormalities (controls). Methods: Core cultures of surgically removed diseased adenoids and of healthy controls were cultured for aerobic and anaerobic bacteria. Results: Polymicrobial aerobic-anaerobic flora were present in all instances. Ninety-four organisms were isolated from control specimens, and 148 from ROM, 142 from RAT, and 149 from OAH specimens. The predominant aerobes in all groups were ␣-hemolytic and ␥-hemolytic streptococci, Haemophilus influenzae, Staphylococcus aureus, group A ␤-hemolytic streptococci, and Moraxella catarrhalis. The prominent anaerobes were Peptostreptococcus, Prevotella, and Fusobacterium species. The number, concentration and distribution of types of most organisms did not vary among the three groups of diseased adenoids. However, the number of those that are potential pathogens and those that produced ␤-lactamase was lower in the control than the diseased adenoids (P < .001). Conclusion: The study highlights the importance of the bacterial load in the adenoids in contributing to the etiology of ROM, RAT, and OAH.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microbiology of Healthy and Diseased Adenoids

2000

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“…Bacteria, especially Haemophilus influenzae and Streptococcus pneumoniae (normal residents of the nasopharynx), have been cultured from up to 40% of the effusions studied [29,31,[56][57][58]. Under direct microscopy, bacteria are more often visible in mucoid than in serous effusions [59].…”

Section: Bacteriamentioning

confidence: 98%

Otitis media with effusion: disease or defense?

Grote

2004

International Journal of Pediatric Otorhinolaryngology

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“…Both eustachian tube dysfunction and repeated bacterial infections are known to be major etiologic factors in OME. [2][3][4] Various biochemical, immunologic, and bacteriologic parameters have been analyzed to identify the significant factors contributing to the chronicity of OME.…”

Section: Introductionmentioning

confidence: 99%

Endotoxin and Lysosomal Protease Activity in Acute and Chronic Otitis Media with Effusion

Sakakura¹,

Hamaguchi²,

Yamagiwa³

et al. 1990

Ann Otol Rhinol Laryngol

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Endotoxin levels and lysosomal protease (collagenase, cathepsin B, and lysozyme) activity were measured in 104 middle ear effusions (MEEs) from patients with otitis media with effusion (OME). The MEE samples were classified into four groups: pediatric serous, mucoid, and acute, and adult serous. Endotoxin levels and lysosomal protease activity in MEEs were significantly different in the following order: adult less than serous less than mucoid less than acute groups, indicating that both endotoxin and lysosomal proteases are more closely related to the pathogenesis of pediatric chronic OME than to adult OME. In pediatric serous and mucoid effusions, endotoxin level had a significant correlation with activity of the lysosomal proteases. In conclusion, endotoxin enhances leukocyte infiltration into the middle ear, and lysosomal proteases released from leukocytes damage the middle ear mucosa and thereby prolong mucosal inflammation, which may be responsible for delayed recovery from acute OME.

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Immune Complexes in the Middle Ear Fluid and Adenoid Tissue in Chronic Secretory Otitis Media

Cited by 29 publications

References 12 publications

Microbiology of Healthy and Diseased Adenoids

Microbiology of Healthy and Diseased Adenoids

Otitis media with effusion: disease or defense?

Endotoxin and Lysosomal Protease Activity in Acute and Chronic Otitis Media with Effusion

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