Immune disorders induced by exposure to pyrethroid insecticides

Skolarczyk, Justyna; Pekar, Joanna; Nieradko-Iwanicka, Barbara

doi:10.5604/01.3001.0010.3827

Cited by 34 publications

(21 citation statements)

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“…Permethrin may cause a variety of symptoms which include epidermal lesions, sore throat, nausea, vomiting, abdominal pain, gastrointestinal mucosal irritation, salivation, respiratory distress and headaches in human [ 5 , 6 ] and animals [ 1 , 5 , 30 ] upon intoxication. It is metabolized by hydrolysis, esterification, oxidation and conjugation [ 1 , 2 ].…”

Section: Permethrinmentioning

confidence: 99%

“…The use of permethrin in household is often associated with allergies and asthma, especially in children. A study of 300 children living in Baltimore showed a decrease in the levels of anti-inflammatory IL-10 in plasma in compared to populations without contact with pyrethroid [ 6 ]. Goksugur et al [ 42 ] presented a case of a 20-month-old child suffering on scabies treated with 5% permethrin on skin who showed agitation and symptoms such as nausea, vomiting, respiratory distress, tachycardia, and metabolic acidosis.…”

Section: Permethrinmentioning

confidence: 99%

“…Deltamethrin caused changes in the immune response in rats fed with the substance for 84 days at a dose of 6 mg/kg or 14 days at a dose of 15 mg/kg [ 6 ]. Decreased blood lymphocyte activity, splenic plaque-forming cells and roosette-forming lymphocytes were observed.…”

Section: Deltamethrinmentioning

confidence: 99%

“…They comprise esters of chrysanthemum acid (ethyl 2,2-dimethyl-3-(1-isobutenyl)cyclopropane-1-carboxylate) and halogenated derivatives of their acids and alcohols [ 1 , 2 , 3 ]. Natural substances found in the extract of Chrysanthemum cinerariaefolium undergo rapid decomposition under the influence of light and therefore they have been replaced with synthetic derivatives, originally considered safe for humans and higher animals [ 1 , 2 , 3 , 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Current Research on the Safety of Pyrethroids Used as Insecticides

et al. 2018

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Pyrethroids are synthetic derivatives of natural pyrethrins extracted from Chrysanthemum cinerariaefolium. They are 2250 times more toxic to insects than to vertebrates due to insects’ smaller size, lower body temperature and more sensitive sodium channels. In particular, three pyrethroid compounds, namely deltamethrin, permethrin, and alpha-cypermethrin, are commonly used as insecticides and are recommended for in-home insect control because they are considered to be relatively non-toxic to humans in all stages of life. However, recent data show that they are not completely harmless to human health as they may enter the body through skin contact, by inhalation and food or water, and absorption level depending on the type of food. Permethrin seems to have an adverse effect on fertility, the immune system, cardiovascular and hepatic metabolism as well as enzymatic activity. Deltamethrin induces inflammation, nephro- and hepatotoxicity and influences the activity of antioxidant enzymes in tissues. Alpha-cypermethrin may impair immunity and act to increase glucose and lipid levels in blood. The aim of the review is to provide comprehensive information on potential hazards associated to human exposure to deltamethrin, permethrin and alpha-cypermethrin. The results of presented studies prove that the insecticides must be used with great caution.

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Section: Permethrinmentioning

confidence: 99%

Section: Permethrinmentioning

confidence: 99%

Section: Deltamethrinmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Current Research on the Safety of Pyrethroids Used as Insecticides

et al. 2018

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“…(1) These effects can be accompanied by the development of other undesirable effects that involve the reproductive, (2,3) immune, (4,5) cardiovascular, (6,7) respiratory (8,9) and other systems, and also contribute to a high risk of cancer development. (10) People contact pyrethroids when they are used in industrial activities and households, as well as from consumption of vegetables, fruits and water contaminated with their residues.…”

Section: Introductionmentioning

confidence: 99%

Impact of Acute Deltamethrin Poisoning on Rat Adrenal Glands: Biochemical and Pathomorphological Study

Chigrinski¹,

Gerunov²,

Gerunova³

et al. 2017

IJBM

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Background: Deltamethrin is known all over the world as an effective preparation for the control of insects. In connection with this, its role as a chemical stressor increases. The aim of the study was to determine the features of the functioning and structure of adrenal glands (AG) after a single administration of synthetic pyrethroid deltamethrin in experimental animals at a dose of 17.4 mg/kg (1/5 LD50).Material and Methods: For the experiment, 88 male Wistar rats with a body weight of 240±10 g were divided into 8 groups of 10-12 animals each. Groups 1, 3, 5, and 7 were control groups, which were administered physiological solution intragastrically. The animals in Groups 2, 4, 6, and 8 received a single dose (17.4 mg/kg) of deltamethrin, which corresponds to 1/5 LD50. In the serum of rats, the content of ACTH, progesterone, DHEAS, corticosterone and aldosterone was determined by EIA. Histological preparations of adrenal glands were stained with H&E, picrofuxin according to Van Gieson, and with Bismarck brown according to Shubich. On frozen sections, lipids were detected by Sudan Black B.Results: One day after intoxication, we identified an increase in adrenal mass, edema of the parenchyma and blood capillary overflow, and a large number of lipids in corticocytes. In the blood serum, the concentration of ACTH and corticosteroids increased, but their level decreased in the adrenal cortex. After 3 days, the concentration of corticosterone in the blood serum of the experimental animals remained above the control value, but the content of other hormones decreased. At the border of the cortex and the medulla of the adrenal glands, there were mast cells in a state of degranulation; the amount of lipids decreased with time. In the subsequent terms of the study, a decrease in the weight of AG with a decrease in the concentration of hormones in the blood serum and adrenal tissue was detected.Conclusion: The intoxication of rats with deltamethrin causes morphofunctional changes in AG that characterize the development of the stress response. The hormonal background is not restored within a month, which indicates the possibility of developing post-toxic complications. (International Journal of Biomedicine. 2017;7(3):221-225.)

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Biodegradation of fenpropathrin by Rhodopseudomonas sp. strain PSB07‐21 cultured under three different growth modes

et al. 2019

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This study aimed at the biodegradation of fenpropathrin by Rhodopseudomonas sp. strain PSB07‐21 cultured under different growth modes. The biomass production, cell surface hydrophobicity and fenpropathrin biodegradation efficiency of the strain PSB07‐21 cultured under the photoheterotrophic growth mode were better than that shown by the strain PSB07‐21 cultured under the photoautotrophic or the chemotrophic growth mode. Sodium dodecyl sulfate–polyacrylamide gel electrophoresis analysis using cell‐free protein extracts showed several distinct protein bands in the gels representing the strain PSB07‐21 cultured under the photoheterotrophic growth mode. The fenpropathrin enzymatic degradation was clearly affected the bacterial growth mode. Results obtained from this study should improve our knowledge regarding fenpropathrin biodegradation under field conditions. Our findings can also be used to optimize the usage of Rhodopseudomonas sp. PSB07‐21 in field applications.

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Immune disorders induced by exposure to pyrethroid insecticides

Cited by 34 publications

References 0 publications

Current Research on the Safety of Pyrethroids Used as Insecticides

Current Research on the Safety of Pyrethroids Used as Insecticides

Impact of Acute Deltamethrin Poisoning on Rat Adrenal Glands: Biochemical and Pathomorphological Study

Biodegradation of fenpropathrin by Rhodopseudomonas sp. strain PSB07‐21 cultured under three different growth modes

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