Immune formulation-assisted conventional therapy on anti-infective effectiveness of multidrug-resistant Mycobacterium tuberculosis infection mice

Yuan, Xin; Wen, Quan; Ni, Mingde; Wang, Likun

doi:10.1016/j.apjtm.2016.01.031

Cited by 5 publications

(3 citation statements)

References 25 publications

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“…Moreover, TNF-α can induce cell differentiation and promote mononuclear cells or T cells to secrete a variety of cytokines [31]. Mature T lymphocytes can be divided into two subsets: CD4 + and CD8 + [32, 33]. CD4 + cells are T helper cells that aid in secreting numerous cytokines and enhance the killing effect of CD8 + cells in tumors [34].…”

Section: Resultsmentioning

confidence: 99%

Optimization of the fermentation process of Cordyceps sobolifera Se-CEPS and its anti-tumor activity in vivo

Yang

Zhang

2016

J Biol Eng

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BackgroundCordyceps sobolifera (C. sobolifera) isolated from cicadae was used as the starting fungus to produce selenium-enriched C. sobolifera extracellular polysaccharide (Se-CEPS). An orthogonal experimental design based on a single-factor experiment was used to optimize the C. sobolifera fermentation conditions, including the potato juice, peptone, and KH2PO4 concentrations. Ultraviolet (UV) and infrared (IR) analyses of CEPS and Se-CEPS were conducted, as well as an in vivo anti-tumor analysis.ResultsUnder optimal conditions (i.e., 40 potato juice, 0.4 KH2PO4, and 0.5 % peptone), the fermentation yield of Se-CEPS was 5.64 g/L. UV and IR spectra showed that Se-CEPS contained a characteristic absorption peak of a selenite Se = O double bond, demonstrating the successful preparation of Se-CEPS. Activity tests showed that Se-CEPS improved the immune organ index, serum cytokine content, and CD8+ and CD4+ T lymphocyte ratio in colon cancer CT26 tumor-bearing mice, thereby inhibiting tumor growth. When combined with 5-FU, Se-CEPS reduced the toxicity and enhanced the function of 5-FU.ConclusionThe result of these experiments indicated that orthogonal experimental design is a promising method for the optimization of Se-CEPS production, and the Se-CEPS from C. sobolifera can improve the anti-tumor capacity of mice.Electronic supplementary materialThe online version of this article (doi:10.1186/s13036-016-0029-0) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Optimization of the fermentation process of Cordyceps sobolifera Se-CEPS and its anti-tumor activity in vivo

Yang

Zhang

2016

J Biol Eng

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“…Thymopentin is a synthetic pentapeptide with immunological activity. In a BALB/c mouse model treated with thymopentin, Th1 and Th17 cells in the peripheral blood increased significantly, while Th2, Treg responses, and programmed cell death protein-1 (PD-1) expression decreased, with no significant side effects when compared with the control group ( Yuan et al., 2016 ). In addition, patients with TB treated with thymopentin combined with chemotherapy showed a synergistic effect with symptom improvement, promoting sputum-negative conversion and lesion absorption ( Wu et al., 2018 ).…”

Section: Immunoactive Substancesmentioning

confidence: 99%

The Research Progress in Immunotherapy of Tuberculosis

Liang

et al. 2021

Front. Cell. Infect. Microbiol.

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Tuberculosis (TB) is a serious public health problem worldwide. The combination of various anti-TB drugs is mainly used to treat TB in clinical practice. Despite the availability of effective antibiotics, effective treatment regimens still require long-term use of multiple drugs, leading to toxicity, low patient compliance, and the development of drug resistance. It has been confirmed that immune recognition, immune response, and immune regulation of Mycobacterium tuberculosis (Mtb) determine the occurrence, development, and outcome of diseases after Mtb infection. The research and development of TB-specific immunotherapy agents can effectively regulate the anti-TB immune response and provide a new approach toward the combined treatment of TB, thereby preventing and intervening in populations at high risk of TB infection. These immunotherapy agents will promote satisfactory progress in anti-TB treatment, achieving the goal of “ultra-short course chemotherapy.” This review highlights the research progress in immunotherapy of TB, including immunoreactive substances, tuberculosis therapeutic vaccines, chemical agents, and cellular therapy.

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“…For example, TP5 increases resistance to infection in mice infected with multidrug-resistant Mycobacterium tuberculosis , reduces the bacterial load in the lungs and spleen, and improves immune functions. 25 TP5 also induces T-cell differentiation, promotes T-lymphocyte subpopulation development, maturation, and activation, and normalizes the CD4 + /CD8 + T-cell ratio. 26 TP5 was likewise found to have substantial LPS-neutralizing activity, as well as the ability to block LPS attachment and intracellular inflammatory responses.…”

Section: Introductionmentioning

confidence: 99%

Thymopentapeptide Affects T-Cell Subsets by Modulating the Flora of the Skin Surface to Alleviate Psoriasis

Liu,

Xi,

et al. 2024

DDDT

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Immune formulation-assisted conventional therapy on anti-infective effectiveness of multidrug-resistant Mycobacterium tuberculosis infection mice

Abstract: Immune formulation thymopentin can enhance the anti-infective ability of multidrug-resistant M. tuberculosis infection mice, decrease bacterial load in lung and spleen, and enhance immune function.

Cited by 5 publications

References 25 publications

Optimization of the fermentation process of Cordyceps sobolifera Se-CEPS and its anti-tumor activity in vivo

Optimization of the fermentation process of Cordyceps sobolifera Se-CEPS and its anti-tumor activity in vivo

The Research Progress in Immunotherapy of Tuberculosis

Thymopentapeptide Affects T-Cell Subsets by Modulating the Flora of the Skin Surface to Alleviate Psoriasis

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