Immune function in intrauterine growth retardation

Neumann, Charlotte G.; Stiehm, E. Richard; Zahradnick, John; Newton, Carter; Weber, Hans; Swendseid, Marian E.; Cherry, James D.; Carney, Jean M.; Bwibo, Nimrod O.; Chotskey, N.; Karuga-Koinange, W.

doi:10.1016/s0271-5317(98)00013-x

Cited by 8 publications

(12 citation statements)

References 36 publications

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“…Consistently, the cord blood levels of IgG, IgA and IgM were markedly lower in IUGR relative to normal infants [ 45 ]. However, an one year longitudinal study showed no significant differences were observed for plasma levels of IgG, IgA and IgM between IUGR and NBW infants [ 46 ]. Regardless of BW, however, feeding NT diet markedly increased plasma concentration of IgA, which is also demonstrated to be higher in weaned pigs receiving nucleotides-containing ingredients [ 37 , 47 ].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, IUGR may negatively affect spleen function according to the lower percentages of G 2 M phase splenocytes, which would inhibit the proliferation of immune cells in spleen [ 48 , 49 ]. Accordingly, the counts of lymphocyte and T-cells were significantly lower in IUGR infants [ 46 ]. In this study, however, cellular immunity-related leukocyte counts and IL-1β concentration as well as IL-1β:IL-10 were markedly increased in IUGR piglets fed NT diet, suggesting IUGR neonates may preferentially utilize nucleotides for cellular immunity.…”

Section: Discussionmentioning

confidence: 99%

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Dietary Nucleotides Supplementation Improves the Intestinal Development and Immune Function of Neonates with Intra-Uterine Growth Restriction in a Pig Model

Che

Liu

et al. 2016

PLoS ONE

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The current study aimed to determine whether dietary nucleotides supplementation could improve growth performance, intestinal development and immune function of intra-uterine growth restricted (IUGR) neonate using pig as animal model. A total of 14 pairs of normal birth weight (NBW) and IUGR piglets (7 days old) were randomly assigned to receive a milk-based control diet (CON diet) or diet supplemented with nucleotides (NT diet) for a period of 21 days. Blood samples, intestinal tissues and digesta were collected at necropsy and analyzed for morphology, digestive enzyme activities, microbial populations, peripheral immune cells, expression of intestinal innate immunity and barrier-related genes and proteins. Compared with NBW piglets, IUGR piglets had significantly lower average daily dry matter intake and body weight gain (P<0.05). Moreover, IUGR markedly decreased the villous height and villi: crypt ratio in duodenum (P<0.05), as well as the maltase activity in jejunum (P<0.05). In addition, IUGR significantly decreased the serum concentrations of IgA, IL-1βand IL-10 (P<0.05), as well as the percentage of peripheral lymphocytes (P<0.05). Meanwhile, the down-regulation of innate immunity-related genes such as TOLLIP (P<0.05), TLR-9 (P = 0.08) and TLR-2 (P = 0.07) was observed in the ileum of IUGR relative to NBW piglets. Regardless of birth weight, however, feeding NT diet markedly decreased (P<0.05) feed conversion ratio, increased the villous height in duodenum (P<0.05), activities of lactase and maltase in jejunum (P<0.05), count of peripheral leukocytes (P<0.05), serum concentrations of IgA and IL-1β as well as gene expressions of TLR-9, TLR-4 and TOLLIP in ileum (P<0.05). In addition, expressions of tight junction proteins (Claudin-1 and ZO-1) in ileum were markedly increased by feeding NT diet relative to CON diet (P<0.05). These results indicated that IUGR impaired growth performance, intestinal and immune function, but dietary nucleotides supplementation improved nutrients utilization, intestinal function and immunity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Dietary Nucleotides Supplementation Improves the Intestinal Development and Immune Function of Neonates with Intra-Uterine Growth Restriction in a Pig Model

Che

Liu

et al. 2016

PLoS ONE

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“…The two longitudinal papers [ 61 , 62 ], the three observational studies nested within controlled trials [ 5 , 63–64 ] and the retrospective cohort study [ 6 ] were assessed with the use of the CASP cohort study checklist with 12 questions [ 65 ]: were the results of the study valid; was the cohort recruited in an acceptable way; was the exposure accurately measured to minimize bias; was the outcome measured to minimize bias; were confounders handled appropriately; was follow-up process described; were the results of the study presented clearly; how precise the results were; whether the results are believable; whether the results were applicable to the local population; did the results of this study fit with other available evidence; and what were the implications of this study for practice, with a star for each criteria. The quality of this group of papers ranged from 7–9 stars, with Ahmad et al .…”

Section: Maternal Nutritional Status and Infant Immune Response To Routmentioning

confidence: 99%

“…Five studies focused on the infant response to BCG vaccine [ 5 , 22 , 61–62 , 64 ], two papers [ 6 , 63 ] investigated the infant response to Hepatitis B vaccine, reviews by Sack et al . and Qadri et al .…”

Section: Maternal Nutritional Status and Infant Immune Response To Routmentioning

confidence: 99%

“…Seven of the studies [ 5–6 , 22 , 61–64 ] provided direct evidence (antibodies, reaction to purified protein derivatives [PPDs], cytokine/chemokine signatures and scar formation) of the infants’ response to vaccines. In eight studies, maternal nutrition status was determined indirectly because it was not quantified, quantification not stated or not available ( Table 4 ) [ 3–5 , 22 , 61–64 ].…”

Section: Maternal Nutritional Status and Infant Immune Response To Routmentioning

confidence: 99%

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Maternal Nutritional Status During Pregnancy and Infant Immune Response to Routine Childhood Vaccinations

Obanewa

Newell

2017

Future Virol.

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To systematically review the association between maternal nutritional status in pregnancy and infant immune response to childhood vaccines. We reviewed literature on maternal nutrition during pregnancy, fetal immune system and vaccines and possible relationships. Thereafter, we undertook a systematic review of the literature of maternal nutritional status and infant vaccine response, extracted relevant information, assessed quality of the nine papers identified and present findings in a narrative format. From limited evidence of average quality, intrauterine nutrition deficiency could lead to functional deficit in the infant's immune function; child vaccine response may thus be negatively affected by maternal malnutrition. Response to childhood vaccination may be associated with fetal and early life environment; evaluation of programs should take this into account.

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Safety and Immunogenicity of Early Bacillus Calmette-Guérin Vaccination in Infants Who Are Preterm and/or Have Low Birth Weights

et al. 2019

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Key Points Question Is administration of bacillus Calmette-Guérin (BCG) vaccination within 7 days of birth safe, immunogenic, and efficacious in infants who are preterm and/or have low birth weight, compared with BCG vaccination at later points or in infants who are normal birth weight? Findings In this systematic review and meta-analysis, we found no increase in adverse reactions or infant mortality after BCG vaccination within 7 days of birth compared with vaccination delayed after 7 days in clinically stable infants who were preterm and/or had low birth weight. Meta-analysis revealed no differences for scar formation or tuberculin skin test conversion. Meaning Currently, evidence from clinically stable infants who were born after more than 30 weeks’ gestational age and/or weighing more than 1.5 kg seems to support BCG vaccination within 7 days of birth.

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Immune function in intrauterine growth retardation

Cited by 8 publications

References 36 publications

Dietary Nucleotides Supplementation Improves the Intestinal Development and Immune Function of Neonates with Intra-Uterine Growth Restriction in a Pig Model

Dietary Nucleotides Supplementation Improves the Intestinal Development and Immune Function of Neonates with Intra-Uterine Growth Restriction in a Pig Model

Maternal Nutritional Status During Pregnancy and Infant Immune Response to Routine Childhood Vaccinations

Safety and Immunogenicity of Early Bacillus Calmette-Guérin Vaccination in Infants Who Are Preterm and/or Have Low Birth Weights

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