Immune-mediated reactions to vancomycin

Minhas, Jasmit S.; Wickner, Paige G.; Long, Aidan A.; Banerji, Aleena; Blumenthal, Kimberly G.

doi:10.1016/j.anai.2016.03.030

Cited by 67 publications

(43 citation statements)

References 79 publications

(40 reference statements)

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“…Vancomycin is known to induce potentially severe allergic and nonallergic reactions that frequently involve the skin . Among these, “red‐man syndrome” is the most prevalent.…”

Section: Discussionmentioning

confidence: 99%

“…Vancomycin is known to induce potentially severe allergic and nonallergic reactions that frequently involve the skin. 3 Among these, "red-man syndrome" is the most prevalent. It is caused by a nonallergic direct histamine release by mast cells and basophils and its incidence has been estimated between 3.7% and 47%, but this is only based on a small series of studies.…”

Section: Discussionmentioning

confidence: 99%

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Skin lesions and vancomycin use in a hemodialysis patient

Schurder

Morel

Blanc³

et al. 2019

Hemodialysis International

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Vancomycin is a widely used antibiotic in hemodialysis patients. The main complications include renal toxicity and skin lesions. Herein, we report the case of a 29‐year‐old hemodialysis patient who presented a bullous pruriginous dermatosis after vancomycin treatment. A skin biopsy revealed a linear IgA bullous dermatosis (LABD). This is a rare form of dermatosis and is either idiopathic or more likely vancomycin‐induced. Similarities in the molecular structure of vancomycin and epidermal basement membrane glycoproteins could explain the auto‐immune response. The overall prognosis after drug discontinuation and dermocorticoid treatment was good.

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“…Vancomycin is known to induce potentially severe allergic and nonallergic reactions that frequently involve the skin . Among these, “red‐man syndrome” is the most prevalent.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Skin lesions and vancomycin use in a hemodialysis patient

Schurder

Morel

Blanc³

et al. 2019

Hemodialysis International

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“…The IgE-medicated reactions occur when it binds to Fc-epsilon-RI receptors, and upon exposure to the allergen, it activates mast and basophil cells to release multiple mediators, enzymes, and cytokines that trigger signs and symptoms of anaphylaxis [28]. Anaphylaxis is a rare but serious immunologically mediated reaction involving drug-specific IgE antibodies [20,[29][30][31][32][33]. The reactions noted due to vancomycin anaphylaxis with demonstrable antibiotic-specific IgE are clinical manifestations described below [29].…”

Section: Incidencementioning

confidence: 99%

Glycopeptide Hypersensitivity and Adverse Reactions

2020

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Glycopeptides, such as vancomycin and teicoplanin, are primarily used in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections, such as cellulitis, endocarditis, meningitis, pneumonia, and septicemia, and are some of the most commonly prescribed parenteral antimicrobials. Parenteral glycopeptides are first-line therapy for severe MRSA infections; however, oral vancomycin is used as a first-line treatment of Clostridioides difficile infections. Also, we currently have the longer-acting lipoglycopeptides, such as dalbavancin, oritavancin, and telavancin to our armamentarium for the treatment of MRSA infections. Lastly, vancomycin is often used as an alternative treatment for patients with β-lactam hypersensitivity. Common adverse effects associated with glycopeptide use include nephrotoxicity, ototoxicity, and Redman Syndrome (RMS). The RMS is often mistaken for a true allergy; however, it is a histamine-related infusion reaction rather than a true immunoglobulin E (IgE)-mediated allergic reaction. Although hypersensitivity to glycopeptides is rare, both immune-mediated and delayed reactions have been reported in the literature. We describe the various types of glycopeptide hypersensitivity reactions associated with glycopeptides and lipoglycopeptides, including IgE-mediated reactions, RMS, and linear immunoglobulin A bullous dermatosis, as well as describe cross-reactivity with other glycopeptides.

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“…Although there is a general notion in the medical community that vancomycin is a safe drug with low allergenic and immunogenic potential, the authors of this review article about immune reactions to vancomycin point out that the use of this drug parenterally or orally is on the rise for serious infections as are the associated adverse effects. 28 The observed frequency of adverse drug reactions to vancomycin is almost 10%. The red-man syndrome is a well described noneIgE-mediated reaction that can be serious and has been described as occurring in 4% to 47% of patients receiving vancomycin.…”

Section: Systemic Allergic and Immune Disordersmentioning

confidence: 99%