Immune Recovery Uveitis Occurring after Chemotherapy and Ocular CMV Infection in Chronic Lymphatic Leukaemia

Wimmersberger, Yves; Balaskas, K.; Gander, M.; Pournaras, J.-A. C.; Guex-Crosier, Yan

doi:10.1055/s-0031-1273226

Cited by 3 publications

(1 citation statement)

References 5 publications

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“…Of the 248 eyes of 178 patients with CMVR in the absence of either HIV infection or Good syndrome that have been described in the literature (Additional file 1 : Table S1), 16 eyes (6.5 %) of 10 patients had one or more features consistent with IRU [ 17 , 20 , 45 , 50 , 70 ]. Reported ages of these 10 patients ranged from 15 to 68 years, with a mean and median of 47.8 and 54 years, respectively.…”

Section: Reviewmentioning

confidence: 99%

Good syndrome and other causes of cytomegalovirus retinitis in HIV-negative patients—case report and comprehensive review of the literature

Downes

Tarasewicz

Weisberg

et al. 2016

J Ophthal Inflamm Infect

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We describe a 65-year-old Thai woman who developed cytomegalovirus retinitis (CMVR) in the setting of Good syndrome—a rare, acquired partial immune deficiency caused by thymoma. The patient subsequently developed vitritis with cystoid macular edema (CME) similar to immune recovery uveitis (IRU) despite control of the retinitis with antiviral agents. A comprehensive review of the literature through December, 2014, identified an additional 279 eyes of 208 patients with CMVR in the absence of human immunodeficiency virus (HIV) infection. Including our newly reported case, 9 of the 208 patients (4.3 %) had Good syndrome. Twenty-one of the 208 patients (10.1 %) had CMVR related to intraocular or periocular corticosteroid administration. The remaining 178 patients (85.6 %) acquired CMVR from other causes. Within the subset of patients who did not have Good syndrome or did not acquire CMVR followed by intraocular or periocular corticosteroid administration, there were many other factors contributing to a decline in immune function. The most common included age over 60 years (33.1 %), an underlying malignancy (28.7 %), a systemic autoimmune disorder requiring systemic immunosuppression (19.1 %), organ (15.2 %) or bone marrow (16.3 %) transplantation requiring systemic immunosuppression, and diabetes mellitus (6.1 %). Only 4.5 % of the patients had no identifiable contributor to a decline in immune function. While the clinical features of CMVR are generally similar in HIV-negative and HIV-positive patients, the rates of moderate to severe intraocular inflammation and of occlusive retinal vasculitis appear to be higher in HIV-negative patients.Electronic supplementary materialThe online version of this article (doi:10.1186/s12348-016-0070-7) contains supplementary material, which is available to authorized users.

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Section: Reviewmentioning

confidence: 99%

Good syndrome and other causes of cytomegalovirus retinitis in HIV-negative patients—case report and comprehensive review of the literature

Downes

Tarasewicz

Weisberg

et al. 2016

J Ophthal Inflamm Infect

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Immune recovery uveitis: a focus review

Rodrigues Alves,

Barão,

Mota

et al. 2024

Graefes Arch Clin Exp Ophthalmol

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Immune recovery uveitis (IRU) is an intraocular inflammation that typically occurs as part of immune reconstitution inflammatory syndrome (IRIS) in the eye. Typically, it affects human immunodeficiency virus (HIV)-infected patients with recognized or unrecognized cytomegalovirus (CMV) retinitis who are receiving highly active antiretroviral therapy (HAART). IRU is a common cause of new vision loss in these patients, and it manifests with a wide range of symptoms and an increased risk of inflammatory complications, such as macular edema. Recently, similar IRU-like responses have been observed in non-HIV individuals with immune reconstitution following immunosuppression of diverse etiologies, posing challenges in diagnosis and treatment. This review provides an updated overview of the current literature on the epidemiology, pathophysiology, biomarkers, clinical manifestations, diagnosis, differential diagnosis, and treatment strategies for IRU.

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Cytomegalovirus retinitis and immune recovery uveitis in a pediatric patient with leukemia

Sariçay

Baldwin²,

Leake³

et al. 2023

Journal of American Association for Pediatric Ophthalmology and

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Immune Recovery Uveitis Occurring after Chemotherapy and Ocular CMV Infection in Chronic Lymphatic Leukaemia

Cited by 3 publications

References 5 publications

Good syndrome and other causes of cytomegalovirus retinitis in HIV-negative patients—case report and comprehensive review of the literature

Good syndrome and other causes of cytomegalovirus retinitis in HIV-negative patients—case report and comprehensive review of the literature

Immune recovery uveitis: a focus review

Cytomegalovirus retinitis and immune recovery uveitis in a pediatric patient with leukemia

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