Immune response in pigs to Aujeszky's disease viruses defective in glycoprotein g1 or gX

Wardley, R.C.; Thomsen, Darrell R.; Berlinski, Pamela J.; Post, Leonard; Meyer, Annette; Petrovskis, Erik; Chester, S. Theodore

doi:10.1016/0034-5288(91)90102-t

Cited by 8 publications

(3 citation statements)

References 15 publications

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“…Experimentally, protective immunity can be induced by inoculation with both live and inactivated ADV vaccines [12,56,61]. However, although both vaccines protect immunized animals from death and/or severe illness due to wild-type ADV challenge, the clinical response has measurable differences [53].…”

Section: Immunity To Inactivated and Modified Live Aujeszky's Diseasementioning

confidence: 99%

Aujeszky's disease virus: opportunities and challenges

Zuckermann¹

2000

Vet. Res.

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-Since its description in 1902, Aujeszky's disease (AD) has become one of the most thoroughly examined viral diseases of swine. The causative agent, Aujeszky's disease virus (ADV), is a neurotropic alphaherpesvirus that produces fatal encephalitis in newborn pigs and a milder syndrome in older animals. In several instances this virus has been used as a test case to examine novel vaccine concepts in swine, including the honor of being the first genetically modified vaccine used in the field. Furthermore, the examination of the immune response to infection or vaccination with this virus has revealed important information about the function of the porcine immune system, including evidence on the existence of a dichotomy between the humoral and cellular immune response in swine. This review presents a summary of research where ADV has been a valuable tool for the development of novel vaccines and has provided information to better understand the immune response of swine to infectious agents. Aujeszky's disease virus / immunity / vaccine / T cells / pigRésumé -Virus de la maladie d'Aujeszky : perspectives et défis. Depuis sa description en 1902, la maladie d'Aujeszky est devenue l'une des maladies virales du porc les plus minutieusement étu-diées. L'agent pathogène responsable de la maladie, le virus de la maladie d'Aujeszky, est un alphaherpesvirus neurotrope qui provoque des encéphalites fatales chez le porc nouveau-né, et un syndrome plus modéré chez les animaux plus âgés. À plusieurs reprises, ce virus a été utilisé expérimentalement pour l'étude de nouveaux concepts vaccinaux chez le porc, et a eu l'honneur d'être le premier vaccin génétiquement modifié utilisé sur le terrain. De plus, l'examen de la réponse immunitaire à l'infection ou à la vaccination par ce virus a révélé des informations importantes concernant le fonctionnement du système immunitaire porcin. En particulier, des preuves de l'existence d'une dichotomie entre les réponses immunitaires humorale et cellulaire chez le porc ont été mises en évidence. Cet article de synthèse résume la recherche pour laquelle ADV a été un outil précieux pour le déve-loppement de nouveaux vaccins, et a apporté des informations pour une meilleure compréhension de la réponse immunitaire du porc aux agents infectieux. Vet. Res. 31 (2000) 121-131 121 virus de la maladie d'Aujeszky / immunité / vaccin / cellules T / porc

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Section: Immunity To Inactivated and Modified Live Aujeszky's Diseasementioning

confidence: 99%

Aujeszky's disease virus: opportunities and challenges

Zuckermann¹

2000

Vet. Res.

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show abstract

Section: Referencesmentioning

confidence: 99%

“…1,5,6,9,10 Typically, wild type pseudorabies viruses (WT-PRV) are both gI and TK positive. 1,5,9,10 Companion diagnostic glycoprotein-specific enzyme-linked immunosorbent assay (ELISA) systems are available; these allow serologic differentiation between swine vaccinated with V-PRV and those exposed to WT-PRV. 5,6,10 Definitive diagnostic differentiation between V-PRV and WT-PRV viruses themselves is, however, a complex process involving restriction endonuclease analysis (REA), Southern blotting with gene-specific DNA probes, and Western blotting with glycoprotein-specific antibodies.…”

Section: Referencesmentioning

confidence: 99%