Immune response to hepatitis B vaccine in pregnant women receiving post-exposure prophylaxis

Vaccines and immunoglobulins

“…There is limited information about the use of hepatitis B vaccine during pregnancy. About 300 pregnancies with vaccinations at various times have been studied, and there is no increased risk of adverse outcomes demonstrated (Sheffield 2011, Reddy 1994, Grosheide 1993, Levy 1991, Ayoola 1987. Almost 90% of the mothers who demonstrated seroconversion after vaccination during pregnancy, developed protective antibodies that could be demonstrated in the umbilical blood (Sheffield 2011, Ingardia 1999.…”

Viral hepatitis vaccination during pregnancy

“…[69][70][71] To our knowledge, no large-scale randomized controlled trials (RCTs) have yet assessed the efficacy and safety of HB vaccines in pregnant women, 72 likely due to ethical issues. 8 However, several studies with small numbers of samples have reported the immunity and safety of recombinant HB vaccines [73][74][75][76][77][78][79][80] and Heptavax, 51,61,81 during pregnancy (Tables 1 and 2), and Heptavax has been replaced by the former vaccines since the 1990s.…”

“…HBV vaccination during pregnancy is reported to be immunogenic, 61,[74][75][76][77]79,80 with a passive transfer of antibodies to the fetus. 61,73,81 However, one study with a limited sample size observed lower anti-HBs titers among infants born to women vaccinated during pregnancy than those born to mothers who acquired immunity before pregnancy, 79 an observation that may suggest that pregnant women should be vaccinated before becoming pregnant.…”

“…61,73,81 However, one study with a limited sample size observed lower anti-HBs titers among infants born to women vaccinated during pregnancy than those born to mothers who acquired immunity before pregnancy, 79 an observation that may suggest that pregnant women should be vaccinated before becoming pregnant. Maternal obesity may also interfere with the efficacy of hepatitis B vaccination in pregnant women.…”

Vaccination during pregnancy: Today's need in India

“…9 Globally, many studies confirmed that there are no adverse pregnancy outcomes reported after vaccinated with HepB vaccine during pregnancy. 10,11 Pregnancy is therefore not considered a contraindication to vaccination, however the Hepatitis B vaccine should be offered for pregnant women who are at high risk for acquiring Hepatitis B infection during pregnancy. 9,12 A mother found to be HBsAg-positive should be followed carefully to ensure that the infant receives Hepatitis B Immunoglobulin and start the hepatitis B vaccine schedule no later than 12 hours after birth and that the infant completes the recommended HepB vaccine schedule.…”