Immune responses in liver and spleen against Plasmodium yoelii pre-erythrocytic stages in Swiss mice model

Siddiqui, Arif Jamal; Bhardwaj, Jyoti; Goyal, Manish; Prakash, Kirtika; Adnan, Mohd; Alreshidi, Mousa; Patel, Mitesh; Soni, Awakash; Redman, Whitni K.

doi:10.1016/j.jare.2020.02.016

Cited by 29 publications

(22 citation statements)

References 44 publications

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“…Malaria, a very common disease globally with a high mortality rate, is caused by Plasmodium, a parasitic organism [121][122][123][124]. The parasite gets into the human body through the bites of infected mosquitoes [125][126][127].…”

Section: Cordycepin and Anti-malarial Effectmentioning

confidence: 99%

Cordycepin for Health and Wellbeing: A Potent Bioactive Metabolite of an Entomopathogenic Medicinal Fungus Cordyceps with Its Nutraceutical and Therapeutic Potential

et al. 2020

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Cordyceps is a rare naturally occurring entomopathogenic fungus usually found at high altitudes on the Himalayan plateau and a well-known medicinal mushroom in traditional Chinese medicine. Cordyceps contains various bioactive components, out of which, cordycepin is considered most vital, due to its utmost therapeutic as well as nutraceutical potential. Moreover, the structure similarity of cordycepin with adenosine makes it an important bioactive component, with difference of only hydroxyl group, lacking in the 3′ position of its ribose moiety. Cordycepin is known for various nutraceutical and therapeutic potential, such as anti-diabetic, anti-hyperlipidemia, anti-fungal, anti-inflammatory, immunomodulatory, antioxidant, anti-aging, anticancer, antiviral, hepato-protective, hypo-sexuality, cardiovascular diseases, antimalarial, anti-osteoporotic, anti-arthritic, cosmeceutical etc. which makes it a most valuable medicinal mushroom for helping in maintaining good health. In this review, effort has been made to bring altogether the possible wide range of cordycepin’s nutraceutical potential along with its pharmacological actions and possible mechanism. Additionally, it also summarizes the details of cordycepin based nutraceuticals predominantly available in the market with expected global value. Moreover, this review will attract the attention of food scientists, nutritionists, pharmaceutical and food industries to improve the use of bioactive molecule cordycepin for nutraceutical purposes with commercialization to aid and promote healthy lifestyle, wellness and wellbeing.

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Section: Cordycepin and Anti-malarial Effectmentioning

confidence: 99%

Cordycepin for Health and Wellbeing: A Potent Bioactive Metabolite of an Entomopathogenic Medicinal Fungus Cordyceps with Its Nutraceutical and Therapeutic Potential

et al. 2020

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“…Though we cannot bring about an instant cure, considering the urgency of eradicating the COVID-19 pandemic, this paper will open new perspectives about plant molecules in developing various strategies against infectious diseases [ 12 , 13 ]. Mother Nature has always been considered as the prime source for the discovery of unique and new bioactive compounds, which have helped in combatting various diseases and infections [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ]. Medicinal plants are known to produce innumerable bioactive metabolites with different pharmacological properties, including anticancer, anti-inflammatory, antimicrobial, antioxidant, anti-malarial, anti-hypertension, anti-ageing, anti-diabetic, anti-hyperlipidemia, anti-osteoporotic, hepato-protective, immunomodulator, etc.…”

Section: Introductionmentioning

confidence: 99%

Plants-Derived Biomolecules as Potent Antiviral Phytomedicines: New Insights on Ethnobotanical Evidences against Coronaviruses

Siddiqui

Danciu

Ashraf

et al. 2020

Plants

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SARS-CoV-2 infection (COVID-19) is in focus over all known human diseases, because it is destroying the world economy and social life, with increased mortality rate each day. To date, there is no specific medicine or vaccine available against this pandemic disease. However, the presence of medicinal plants and their bioactive molecules with antiviral properties might also be a successful strategy in order to develop therapeutic agents against SARS-CoV-2 infection. Thus, this review will summarize the available literature and other information/data sources related to antiviral medicinal plants, with possible ethnobotanical evidence in correlation with coronaviruses. The identification of novel antiviral compounds is of critical significance, and medicinal plant based natural compounds are a good source for such discoveries. In depth search and analysis revealed several medicinal plants with excellent efficacy against SARS-CoV-1 and MERS-CoV, which are well-known to act on ACE-2 receptor, 3CLpro and other viral protein targets. In this review, we have consolidated the data of several medicinal plants and their natural bioactive metabolites, which have promising antiviral activities against coronaviruses with detailed modes of action/mechanism. It is concluded that this review will be useful for researchers worldwide and highly recommended for the development of naturally safe and effective therapeutic drugs/agents against SARS-CoV-2 infection, which might be used in therapeutic protocols alone or in combination with chemically synthetized drugs.

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“…The colorimetric 2, 3-Bis(2-methoxy-4-nitro-5-sulfophenyl)-5-[(phenyl-amino)carbonyl]-2H-tetrazolium hydroxide (XTT) reduction test was carried out to estimate the bacterial cells viability within the biofilms by following previously reported methods [ 33 , 34 , 35 ]. Overnight culture of respective bacterial strains was inoculated into MHB (200 µL) at an initial turbidity of 0.1 at 600 nm, grown with and without mucus extract at 37 °C without shaking for 24 h. After incubation, plates were washed three times with distilled water to remove the planktonic cells and wells were filled with sterile PBS (100 µL) and freshly prepared solution of XTT-menadione (100 µL).…”

Section: Methodsmentioning

confidence: 99%

Profiling and Role of Bioactive Molecules from Puntius sophore (Freshwater/Brackish Fish) Skin Mucus with Its Potent Antibacterial, Antiadhesion, and Antibiofilm Activities

et al. 2020

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Epidermal fish mucus comprises of diverse bioactive metabolites which plays an immense role in defense mechanisms and other important cellular activities. Primarily, this study aims to screen the unexplored mucus extract of Puntius sophore (P. sophore) for its antagonistic potential against common pathogens, which are commonly implicated in foodborne and healthcare associated infections, with effects on their adhesion and biofilm formation. Profiling of the skin mucus was carried out by High Resolution-Liquid Chromatography Mass Spectrometry (HR-LCMS), followed by antibacterial activity and assessment of antibiofilm potency and efficacy on the development, formation, and texture of biofilms. Furthermore, bacterial cell damage, viability within the biofilm, checkerboard test, and cytotoxicity were also evaluated. As a result, P. sophore mucus extract was found to be effective against all tested strains. It also impedes the architecture of biofilm matrix by affecting the viability and integrity of bacterial cells within biofilms and reducing the total exopolysaccharide content. A synergy was observed between P. sophore mucus extract and gentamicin for Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa), and Bacillus subtilis (B. subtilis), whereas, an additive effect for Staphylococcus aureus (S. aureus). Thus, our findings represent the potent bioactivities of P. sophore mucus extract for the first time, which could be explored further as an alternative to antibiotics or chemically synthesized antibiofilm agents.

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Immune responses in liver and spleen against Plasmodium yoelii pre-erythrocytic stages in Swiss mice model

Cited by 29 publications

References 44 publications

Cordycepin for Health and Wellbeing: A Potent Bioactive Metabolite of an Entomopathogenic Medicinal Fungus Cordyceps with Its Nutraceutical and Therapeutic Potential

Cordycepin for Health and Wellbeing: A Potent Bioactive Metabolite of an Entomopathogenic Medicinal Fungus Cordyceps with Its Nutraceutical and Therapeutic Potential

Plants-Derived Biomolecules as Potent Antiviral Phytomedicines: New Insights on Ethnobotanical Evidences against Coronaviruses

Profiling and Role of Bioactive Molecules from Puntius sophore (Freshwater/Brackish Fish) Skin Mucus with Its Potent Antibacterial, Antiadhesion, and Antibiofilm Activities

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