Immune system in cancer and hydatid disease: cross‐reactivity vs. immune modulation

Esendağlı, Güneş; Abbasoğlu, Osman

doi:10.1111/pim.12200

Cited by 5 publications

(4 citation statements)

References 9 publications

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“…The presence of Tn antigen in larval and adult tissues of E. granulosus was reported [52], this finding is interested in cancer-associated mucin-type because this parasite produced peptides can act on the nonspecific natural killer cell to express cytokines that are effective agents against tumor growth; therefore, the family of Tn antigens might be useful targets for antitumor immunotherapy [41,53,54]. These evidences may contribute to the design of tumor vaccines and open new horizons in the use of parasite-derived molecules that can fight against cancer [55,56].…”

Section: Using Parasite Productions For Cancer Treatmentmentioning

confidence: 99%

Current Research Advance on Echinococcosis

Yang¹,

Zhao²,

McManus³

et al. 2017

Echinococcosis

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Echinococcosis is caused by infection with larva (metacestode) of the tapeworms of the genus Echinococcus. Within genus Echinococcus, two species are known as public health concern worldwide: Echinococcus guanulosus causing cystic echinococcosis (CE) and Echinococcus multilocularis causing alveolar echinococcosis (AE). The co-evaluation due to the interaction between parasites and their hosts has been well known to be able to allow tolerating to maintain parasitism as long as possible. With many research advanced findings, scientists have been much interested in using either those molecules from parasites producing due to invading and surviving or those cytokines from hosts responding due to defenses to carry out immunotherapeutic practice that is not only against parasitic infection but also for cancer or other immunological related disorders. Taken advance of knowledge on Echinococcus genome research outcomes, recent attentions regarding the discoveries of targeting antiparasitic drug and/or vaccine were extensively discussed in this review.

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Section: Using Parasite Productions For Cancer Treatmentmentioning

confidence: 99%

Current Research Advance on Echinococcosis

Yang¹,

Zhao²,

McManus³

et al. 2017

Echinococcosis

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“…Antitumor effect of the hydatid cyst fluid has been shown in different previously published works. [23242526272829] In an investigation effect of two hydatid cyst antigens on the growth of melanoma cancer in C57/black mice has been demonstrated. [23] In another work done by Barrel et al ., antitumor activity of human hydatid cyst fluid in a murine model of colon cancer has been shown.…”

Section: Introductionmentioning

confidence: 99%

Identifying the most effective hydatid cyst fluid fraction for anticancer vaccination of 4T1 breast tumor-bearing mice

et al. 2019

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Background: The hydatid cyst fluid antigens have high homology with cancer cell antigens and also exhibit considerable immunogenicity. Therefore, their utilization for cancer immunization can cause an effective antitumor immune response. However, the main challenge is identifying the most effective antigens for this purpose. Methods: Hydatid cyst fluid fractions including the glycolipid fraction, glycoprotein fraction, 78 kDa fraction, and antigen B fraction were prepared. Then, the BALB/c mice were immunized against different antigens and, subsequently, 4T1 cells were subcutaneously implanted. The tumors' growth, metastasis, and tumor-bearing mice survival were assessed in different immunized groups. In addition, IL-2, IL-4, IFN-γ, and TNF-α serum levels were estimated to evaluate the immune system response. Results: BALB/c mice immunization against the complete hydatid cyst fluid antigens exhibited more significant inhibition of the tumors' growth and metastasis and increase of tumor-bearing mice survival in comparison with its derived fractions. However, the 78 kDa fraction exhibited the best results according to the same factors in comparison with all the prepared fractions. Conclusions: The 78 kDa fraction of the hydatid cyst fluid was the most effective fraction of hydatid cyst fluid for immunization against 4T1 breast tumors.

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“…Immunity is implicated in the eradication and in promotion of both cancer and echinococcosis [8]. Immune modulation may be considered a critical factor influencing the course and severity of the parasitic disease.…”

mentioning

confidence: 99%

“…In fact, Echinococcus spp. could use two main mechanisms to subvert the host immune response: passive escape, in which the parasite, by developing into a larval form, avoids the damaging effects of an immune response, and immunomodulation, through which the parasite actively interacts with the host immune system to reduce the impact of a host response [8].…”

mentioning

confidence: 99%

Cerebral cystic echinococcosis reactivation during therapy for squamous tumor of the cervix: possible interactions?

Lupia,

Fornari,

Gaviraghi

et al. 2023

J Infect Dev Ctries

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Immune system in cancer and hydatid disease: cross‐reactivity vs. immune modulation

Cited by 5 publications

References 9 publications

Current Research Advance on Echinococcosis

Current Research Advance on Echinococcosis

Identifying the most effective hydatid cyst fluid fraction for anticancer vaccination of 4T1 breast tumor-bearing mice

Cerebral cystic echinococcosis reactivation during therapy for squamous tumor of the cervix: possible interactions?

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