Immunity at the Barriers

Belkaid, Yasmine; Artis, David

doi:10.1002/eji.201344133

Cited by 14 publications

(11 citation statements)

References 13 publications

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“…Ideally, diseasemodifying asthma therapies (DMATs) should target fundamental pathobiological mechanisms involved in asthma and/or pathologic alterations in lung structure. Evidence suggests that the mucosal immune system (16), and specifically airway epithelial-derived signals, play a pivotal role in asthma (17). In addition, dysregulation of innate antiviral defenses (17) and/or the role of type 2 inflammation are important features of disease pathobiology in many individuals with asthma.…”

Section: Disease Modificationmentioning

confidence: 99%

Future Research Directions in Asthma. An NHLBI Working Group Report

Levy

Noël

Freemer

et al. 2015

Am J Respir Crit Care Med

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Asthma is a common chronic disease without cure. Our understanding of asthma onset, pathobiology, classification, and management has evolved substantially over the past decade; however, significant asthma-related morbidity and excess healthcare use and costs persist. To address this important clinical condition, the NHLBI convened a group of extramural investigators for an Asthma Research Strategic Planning workshop on September 18-19, 2014, to accelerate discoveries and their translation to patients. The workshop focused on (1) in utero and early-life origins of asthma, (2) the use of phenotypes and endotypes to classify disease, (3) defining disease modification, (4) disease management, and (5) implementation research. This report summarizes the workshop and produces recommendations to guide future research in asthma.

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Section: Disease Modificationmentioning

confidence: 99%

Future Research Directions in Asthma. An NHLBI Working Group Report

Levy

Noël

Freemer

et al. 2015

Am J Respir Crit Care Med

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“…The specialized immune networks present at barrier sites coexist with the commensal microbial world yet are still able to combat harmful insults and infection. Maintenance of immunological tolerance and tissue homeostasis relies on tissue- tailored immunological networks that are specialized to receive and integrate local cues and induce responses that preserve the physiological function of a specific tissue 1 . In the oral cavity, the local immune cell network is exposed to alimentary and airborne antigens and commensal microbes, which are encountered here for the first time prior to their entry into the gastrointestinal tract and respiratory system.…”

Section: Introductionmentioning

confidence: 99%

“…In fact the microbial communities of the oral cavity and stool were the most diverse of all examined, in terms of community membership 4 , 5 . How these unique microbial communities contribute to the evolution of the local immune system is currently a topic of tremendous interest in the field of barrier site immunity 1 . To date this has not been examined at the oral barrier, partly owing to a limited understanding of the specialized immune network active at this barrier site.…”

Section: Introductionmentioning

confidence: 99%

Characterization of the human immune cell network at the gingival barrier

et al. 2016

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The oral mucosa is a barrier site constantly exposed to rich and diverse commensal microbial communities, yet little is known of the immune cell network maintaining immune homeostasis at this interface. We have performed a detailed characterization of the immune cell subsets of the oral cavity in a large cohort of healthy subjects. We focused our characterization on the gingival interface, a particularly vulnerable mucosal site, with thin epithelial lining and constant exposure to the tooth adherent biofilm. In health, we find a predominance of T cells, minimal B cells, a large presence of granulocytes/neutrophils, a sophisticated network of professional antigen presenting cells (APC) and a small population of innate lymphoid cells (ILC) policing the gingival barrier. We further characterize cellular subtypes in health and interrogate shifts in immune cell populations in the common oral inflammatory disease periodontitis. In disease we document an increase in neutrophils and an up-regulation of IL-17 responses. We identify the main source of IL-17 in health and periodontitis within the CD4+ T cell compartment. Collectively our studies provide a first view of the landscape of physiologic oral immunity and serve as a baseline for the characterization of local immunopathology.

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“…An optimal immune system-microbiota alliance allows the induction of protective responses to pathogens and the maintenance of regulatory pathways to the tolerance to innocuous antigens. Nevertheless, a mutual impact of the gastrointestinal tract (GIT) and central nervous system (CNS) functions was recognized since the mid-twentieth century, and it has been accepted that the so-called gut-brain axis provides a two-way homeostatic communication, through immunological, hormonal and neuronal signals [ 10 , 11 ].…”

Section: Lecture Highlightsmentioning

confidence: 99%

Neuroimmunology Research. A Report from the Cuban Network of Neuroimmunology

Robinson-Agramonte

Pedré

Serrano-Barrera

2018

Behavioral Sciences

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Neuroimmunology can be traced back to the XIX century through the descriptions of some of the disease’s models (e.g., multiple sclerosis and Guillain Barret syndrome, amongst others). The diagnostic tools are based in the cerebrospinal fluid (CSF) analysis developed by Quincke or in the development of neuroimmunotherapy with the earlier expression in Pasteur’s vaccine for rabies. Nevertheless, this field, which began to become delineated as an independent research area in the 1940s, has evolved as an innovative and integrative field at the shared edges of neurosciences, immunology, and related clinical and research areas, which are currently becoming a major concern for neuroscience and indeed for all of the scientific community linked to it. The workshop focused on several topics: (1) the molecular mechanisms of immunoregulation in health and neurological diseases, (like multiple sclerosis, autism, ataxias, epilepsy, Alzheimer and Parkinson’s disease); (2) the use of animal models for neurodegenerative diseases (ataxia, fronto-temporal dementia/amyotrophic lateral sclerosis, ataxia-telangiectasia); (3) the results of new interventional technologies in neurology, with a special interest in the implementation of surgical techniques and the management of drug-resistant temporal lobe epilepsy; (4) the use of non-invasive brain stimulation in neurodevelopmental disorders; as well as (5) the efficacy of neuroprotective molecules in neurodegenerative diseases. This paper summarizes the highlights of the symposium.

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Immunity at the Barriers

Cited by 14 publications

References 13 publications

Future Research Directions in Asthma. An NHLBI Working Group Report

Future Research Directions in Asthma. An NHLBI Working Group Report

Characterization of the human immune cell network at the gingival barrier

Neuroimmunology Research. A Report from the Cuban Network of Neuroimmunology

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