Immunity to melanin and to tyrosinase in melanoma patients, and in people with vitiligo

Đorđić, Marija; Matić, Ivana Z.; Filipovic-Ljeskovic, I.; Džodić, Radan; Sasić, M; Erić-Nikolić, Aleksandra; Vuletić, Ana; Kolundžija, Branka; Damjanović, Ana; Grozdanić, Nađa; Nikolić, Sonja; Pralica, J; Dobrosavljevic, Danijela; Rašković, Sanvila; Andrejević, Slađana; Juranić, Zorica D.

doi:10.1186/1472-6882-12-109

Cited by 13 publications

(8 citation statements)

References 34 publications

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“…Not much is known about melanoma-specific antibodies and their relation to clinical outcome from literature. 22-24 The majority of immunomonitoring in immunotherapy studies focus on T-cell responses, in particular specific CD8+ T-cell responses using tetramer technology or activation assays. We demonstrated that patients with melanoma-associated vitiligo have antibodies against gp100, tyrosinase and MART-1 in their serum while MART-1 antibodies were undetectable in vitiligo patients, 4 indicating their potential role in the melanoma-associated vitiligo.…”

Section: Discussionmentioning

confidence: 99%

Anti-Melanoma immunity and local regression of cutaneous metastases in melanoma patients treated with monobenzone and imiquimod; a phase 2 a trial

et al. 2018

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Vitiligo development in melanoma patients during immunotherapy is a favorable prognostic sign and indicates breakage of tolerance against melanocytic/melanoma antigens. We investigated a novel immunotherapeutic approach of the skin-depigmenting compound monobenzone synergizing with imiquimod in inducing antimelanoma immunity and melanoma regression. Stage III-IV melanoma patients with non-resectable cutaneous melanoma metastases were treated with monobenzone and imiquimod (MI) therapy applied locally to cutaneous metastases and adjacent skin during 12 weeks, or longer. Twenty-one of 25 enrolled patients were evaluable for clinical assessment at 12 weeks. MI therapy was well-tolerated. Partial regression of cutaneous metastases was observed in 8 patients and stable disease in 1 patient, reaching the statistical endpoint of treatment efficacy. Continued treatment induced clinical response in 11 patients, including complete responses in three patients. Seven patients developed vitiligo-like depigmentation on areas of skin that were not treated with MI therapy, indicating a systemic effect of MI therapy. Melanoma-specific antibody responses were induced in 7 of 17 patients tested and melanoma-specific CD8+T-cell responses in 11 of 15 patients tested. These systemic immune responses were significantly increased during therapy as compared to baseline in responding patients. This study shows that MI therapy induces local and systemic anti-melanoma immunity and local regression of cutaneous metastases in 38% of patients, or 52% during prolonged therapy. This study provides proof-of-concept of MI therapy, a low-cost, broadly applicable and well-tolerated treatment for cutaneous melanoma metastases, attractive for further clinical investigation.

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Section: Discussionmentioning

confidence: 99%

Anti-Melanoma immunity and local regression of cutaneous metastases in melanoma patients treated with monobenzone and imiquimod; a phase 2 a trial

et al. 2018

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“…tyrosinase) are highly immunogenic. 34,35 Various kinds of melanins revealed immunomodulatory activity by regulating cytokine production by T-lymphocytes and monocytes, as well as fibroblasts and endothelial cells. 34 It was even reported that the edible mushrooms, as they are a rich source of melanin and tyrosinase, may induce immunity to these antigens in humans.…”

Section: Discussionmentioning

confidence: 99%

“…34 It was even reported that the edible mushrooms, as they are a rich source of melanin and tyrosinase, may induce immunity to these antigens in humans. 35 The possible role of melanin-related antigens in human autoimmunity remains, however, a field of research.…”

Section: Discussionmentioning

confidence: 99%

Alternaria scalp infection in a patient with alopecia areata. Coexistence or causative relationship?

Rudnicka¹,

Lukomska²

2012

J Dermatol Case Rep

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“…Various kinds of melanins revealed immunomodulatory activity by regulating cytokine production by T-lymphocytes and monocytes, as well as fibroblasts and endothelial cells [15]. It was even reported that the edible mushrooms, as they are a rich source of melanin and tyrosinase, may induce immunity to these antigens in humans [16].…”

Section: Discussionmentioning

confidence: 99%

“…tyrosinase) are highly immunogenic [16]. Various kinds of melanins revealed immunomodulatory activity by regulating cytokine production by T-lymphocytes and monocytes, as well as fibroblasts and endothelial cells [15].…”

Section: Discussionmentioning

confidence: 99%

Presence of Alternaria in Scalp of Patients with Alopecia Areata: Triggering Factor or Coexistence?

Gaber¹,

Mohamed²,

Gaber³

2015

JLS

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AA (Alopecia areata) is the most frequent cause of inflammation-induced hair loss, affecting 0.1 to 0.2% of population worldwide. The development of organ-specific autoimmune reactions directed against anagen hair follicles seems to play a key role in the pathogenesis of alopecia areata. However, the triggering antigen(s) responsible for inducing autoimmune phenomena in these individuals remain unknown. Viral, bacterial or fungal pathogens have been implied as possible triggering factors of autoimmune reactions. The present study aims to identify the role of dematiaceous fungi in the pathogenesis of alopecia areata. 30 patients diagnosed clinically as alopecia areata and 30 normal age matched persons have undergone mycological examination. Mycology examination of the epidermal scrapings was done by DME (direct microscopic examination), culture on SDA (sabouraud's dextrose agar) and imaging. There is significantly higher percentage of positive results for Alternaria species by culture on sabouraud's agar in patients group (20%) compared to controls (13.3%) P-value < 0.05. The possible role of Alternaria antigens (e.g. antigens involved in melanin synthesis) in triggering autoimmunity in alopecia areata still needs further research on a wider scale of cases.

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Immunity to melanin and to tyrosinase in melanoma patients, and in people with vitiligo

Cited by 13 publications

References 34 publications

Anti-Melanoma immunity and local regression of cutaneous metastases in melanoma patients treated with monobenzone and imiquimod; a phase 2 a trial

Anti-Melanoma immunity and local regression of cutaneous metastases in melanoma patients treated with monobenzone and imiquimod; a phase 2 a trial

Alternaria scalp infection in a patient with alopecia areata. Coexistence or causative relationship?

Presence of Alternaria in Scalp of Patients with Alopecia Areata: Triggering Factor or Coexistence?

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