Immunity to Placental Malaria. IV. Placental Malaria Is Associated with Up‐Regulation of Macrophage Migration Inhibitory Factor in Intervillous Blood

Chaisavaneeyakorn, Sujittra; Moore, Julie M.; Othoro, Caroline; Otieno, Juliana A.; Chaiyaroj, Sansanee C.; Shi, Ya Ping; Nahlen, Bernard L.; Lal, Altaf A.; Udhayakumar, Venkatachalam

doi:10.1086/344322

Cited by 59 publications

(57 citation statements)

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“…Our studies demonstrated that MIF is elevated 300 to 500 fold in placental intervillous blood (IVB) plasma compared to peripheral blood plasma (9). In PM-positive women, there was a significant increase in IVB MIF levels compared to PMnegative women.…”

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confidence: 68%

“…A double sandwich enzyme-linked immunosorbent assay was used to measure MIF levels in culture supernatants as previously described (9). MIF was detected with a capture mouse monoclonal anti-human MIF antibody (clone 12302.2) and a biotinylated goat anti-human MIF antibody from R&D Systems, Inc. (Minneapolis, MN).…”

Section: Methodsmentioning

confidence: 99%

“…Recently, we proposed that macrophage migration inhibitory factor (MIF), which is the only cytokine thus far known to counterregulate the immunosuppressive effect of glucocorticoids (8), may play an important role in modulating protective immune responses to infectious agents such as malaria parasites at the placental level (9). MIF is a unique cytokine in that it has properties of a cytokine, enzyme, and hormone (7).…”

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confidence: 99%

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Immunohistological Characterization of Macrophage Migration Inhibitory Factor Expression inPlasmodium falciparum-Infected Placentas

et al. 2005

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Previously, we have shown that macrophage migration inhibitory factor (MIF) was highly elevated in the placental intervillous blood (IVB) of Plasmodium falciparum-infected women. Here, we compared the expression of MIF in placental tissues obtained from P. falciparum-infected and -uninfected women. Immunoperoxidase staining showed a consistent pattern of MIF expression in syncytiotrophoblasts, extravillous trophoblasts, IVB mononuclear cells, and amniotic epithelial cells, irrespective of their malaria infection status. Cytotrophoblast, villous stroma, and Hofbauer cells showed focal staining. Only amniotic epithelial and IVB mononuclear cells from P. falciparum-infected placentas exhibited significantly higher level of MIF expression than uninfected placentas. Stimulation of syncytilized human trophoblast BeWo cells with P. falciparum-infected erythrocytes that were selected to bind these cells resulted in significant increases in MIF secretion, whereas control erythrocytes, lipopolysaccharides, and synthetic ␤-hematin had minimal effect. These findings suggest that placental malaria modulates MIF expression in different placental compartments.

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confidence: 68%

Section: Methodsmentioning

confidence: 99%

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Immunohistological Characterization of Macrophage Migration Inhibitory Factor Expression inPlasmodium falciparum-Infected Placentas

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“…15, 17-20 Consistent in its role as mediator of innate immunity and inflammation, MIF is induced in various infections, including those that occur during pregnancy. 15,18 There is a lack of data in humans on the alteration of MIF in psychological stress or other behavioral risk factors for preterm delivery. Studies in vitro and experimental animals suggest that MIF secretion is induced by psychological stress, and the stress hormone, corticotropin releasing hormone (CRH), 10, 21 Thus MIF is linked with infections, reproductive function, and psychological stress, but the details of how MIF may participate in PTD are lacking.…”

Section: Introductionmentioning

confidence: 99%

Serum macrophage migration inhibitory factor in the prediction of preterm delivery

Pearce

Garvin

Grove

et al. 2008

American Journal of Obstetrics and Gynecology

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Serum Macrophage Migration Inhibitory Factor in the Prediction of Preterm Delivery.Objective-Macrophage migration inhibitory factor (MIF) is a soluble mediator that helps govern the interaction between cytokines and stress hormones (e.g. cortisol). We determined if maternal MIF levels predicted subsequent preterm delivery (PTD).Study Design-A nested case-control study measuring serum MIF concentration at 9-23 weeks gestation in women who ultimately delivered preterm (n=60) compared to control women who delivered at term (n=122). We also examined the connection of MIF with self-reported psychosocial variables.Results-MIF was elevated in the PTD cases (p=0.0004), and log MIF concentration showed a graded response relationship with likelihood of PTD. High MIF was also associated with maternal risk-taking behavior, which itself was a risk factor for PTD. MIF remained associated independently with PTD after adjusting regression models for several other PTD risk factors (OR, 3.11, 95% CI 1.54-6.30).Conclusion-High serum MIF concentration in early to mid-pregnancy is linked with subsequent preterm delivery.

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“…Migration inhibitory factor (MIF) merangsang fagositosis eritrosit terinfeksi juga mendorong akumulasi makrofag di plasenta [38]. Konsentrasi MIF lebih tinggi pada ibu hamil primigravida dari pada multigravida disebabkan karena kadar steroid pada primigravida lebih tinggi, oleh karena itu peningkatan konsentrasi MIF dapat memberikan perlindungan pada plasenta [39].…”

Section: Repon Imun Terhadap Infeksi Malaria Selama Kehamilanunclassified

Malaria Pada Kehamilan Dan Konsekuensinya Pada Ibu Dan Janin

Rahmah

2017

JIM

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ABSTRAKMalaria merupakan penyakit infeksi yang masih menjadi masalah kesehatan utama di dunia. Malaria menyerang individu tampa membedakan umur dan jenis kelamin tidak terkecuali ibu hamil. Ibu hamil memiliki resiko terserang malaria oleh parasit Plasmodium lebih berat di bandingkan dengan wanita tidak hamil. Ketika seorang hamil akan terjadi supresi imun baik humoral maupun seluler Tujuan makalah ini untuk membahas mekanisme terjadinya malaria pada kehamilan dan konsekuensinya pada ibu dan janin. Adhesi parasit dengan reseptor Chondroitin Sulfate A (CSA) dan Hyaluronic Acid (HA) di plasenta dapat memicu proses inflamasi yang melibatkan sekresi sitokin. Komponen inflamasi yang muncul setelah akumulasi parasit di plasenta berasosiasi dengan patologi imun pada Pregnancy-Associated Malaria (PAM), seperti penebalan membran sitotrofoblas yang mengganggu aliran darah, menghambat transfer IgG melintasi plasenta dan pertukaran nutrisi dari ibu ke janin sehingga terjadi lesi pada plasenta. Selama kehamilan yang terinfeksi malaria terjadi proses cytoadherence di mediasi oleh protein Plasmodium falciparum Erythrocyte Membran Protein-1 (PfEMP-1) dikode oleh gen Var2 CSA yang mengikat reseptor di plasenta hal ini menyebabkan sekuestrasi eritrosit terinfeksi di sel endotel yang mengakibatkan terjadinya anemia pada ibu sedangkan pada janin menyebabkan berat badan lahir rendah, lahir prematur dan lahir mati. Kata kunci : Malaria, Ibu Hamil, Janin ABSTRACTMalaria is an infectious disease remains a major health problem in the world. Malaria attacks without differentiating individual age and sex of pregnant women are no exception. Pregnant women have a risk of malaria by Plasmodium parasites is more severe in comparison with non-pregnant women. When a pregnancy will occur immunosuppression both humoral and cellular purpose of this paper is to discuss the mechanism of occurrence of malaria in pregnancy and its consequences on the mother and fetus. Parasite adhesion receptors Chondroitin Sulfate A (CSA) and Hyaluronic Acid (HA) in the placenta can trigger an inflammatory process involving the secretion of cytokines. Inflammatory component that appears after the accumulation of parasites in the placenta is associated with immune pathology in the Pregnancy-Associated Malaria (PAM), such as thickening of the membrane cytotrophoblasts that disrupt blood flow, inhibiting the transfer of IgG across the placenta and the exchange of nutrients from mother to fetus, causing lesions in the placenta. Malaria infection during pregnancy is a process of mediation by protein cytoadherence in Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP-1) encoded by genes that bind to receptors on Var2CSA this causes placental sequestration of infected erythrocytes on endothelial cells resulting in anemia in pregnant while on fetus causes low birth weight, premature birth and stillbirth.

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Immunity to Placental Malaria. IV. Placental Malaria Is Associated with Up‐Regulation of Macrophage Migration Inhibitory Factor in Intervillous Blood

Cited by 59 publications

References 14 publications

Immunohistological Characterization of Macrophage Migration Inhibitory Factor Expression inPlasmodium falciparum-Infected Placentas

Immunohistological Characterization of Macrophage Migration Inhibitory Factor Expression inPlasmodium falciparum-Infected Placentas

Serum macrophage migration inhibitory factor in the prediction of preterm delivery

Malaria Pada Kehamilan Dan Konsekuensinya Pada Ibu Dan Janin

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