Immunization against Invasive Candidiasis is the Exigency of the Decade

Abstract

Fungal infections by Candida spp. have emerged as one of the major concerns of high mortality in immunocompromised patients. It is one of the kingpins of the critical priority group of WHO fungal priority pathogens list 2022. Modern medicine has made its way for the better treatment of diseases and bacterial infections. But with drug-resistance in bacteria causing millions of deaths and to add on the trouble, invasive fungal infections which remains unnoticed is culminating into a challenge among the immunocompromised patients. A proper understanding of the host-pathogen interaction and the detailed immunology against fungal pathogens provides a better insight. This helps in development of efficient strategies for new generation antifungals and vaccination. In this review invasive fungal infections or fungemia caused by Candida species will be the heart. According to WHO fungal priority pathogens list (WHO FPPL 2022) for this group of fungus no commercial vaccine is available and it has become the need of this decade. The current efforts and preventive strategies studied against this infection will help in the up growth of vaccination against Invasive Candidiasis (IC).