Immunization Coverage Among Infants Enrolled in the Tennessee Medicaid Program

Griffin, Marie R.; Daugherty, James R.; Reed, George W.; Standaert, Steven M.; Hutchins, Sonja S.; Hutcheson, Robert H.; Schaffner, William

doi:10.1001/archpedi.1995.02170180089017

Cited by 18 publications

(6 citation statements)

References 17 publications

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“…This finding has been demonstrated in the United States, but to our knowledge, has not been previously documented in resource-constrained settings. [34][35][36][37] In this setting, delayed pentavalent1 vaccine could be used as an early warning system to alert practitioners that this child is at higher risk for drop-out of the EPI schedule.…”

Section: Discussionmentioning

confidence: 99%

Individual level determinants for not receiving immunization, receiving immunization with delay, and being severely underimmunized among rural western Kenyan children

Gibson

Ochieng

Kagucia

et al. 2015

Vaccine

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Section: Discussionmentioning

confidence: 99%

Individual level determinants for not receiving immunization, receiving immunization with delay, and being severely underimmunized among rural western Kenyan children

Gibson

Ochieng

Kagucia

et al. 2015

Vaccine

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“…AD is pathologically characterized by the accumulation of amyloid-beta (Aβ) plaques, tau neurofibrillary tangles (NFTs), synaptic and neuronal loss, glial activation, and neuroinflammation [6][7][8][9][10][11]. Aβ plaques and NFTs induce an immune response associated with astroglia and microglia activation and increased inflammatory mediators, tumor necrosis factor α [12], S100, interleukin 1 [13,14], such as triggering receptor expressed on myeloid cells 2 (TREM2) [15,16], and complement activation (C1q to C5b-9) [17] in AD [18][19][20]. Recently, the chitinase family of inflammatory proteins, particularly chitinase 3-like 1 (CHI3L1, YKL-40, or HC gp-39), chitinase 3-like 2 (CHI3L2 or YKL- 39), and pentraxin II (NPTX2 or Narp), a member of the pentraxin family, has been associated with AD pathogenesis [21,22].…”

Section: Introductionmentioning

confidence: 99%

Frontal cortex chitinase and pentraxin neuroinflammatory alterations during the progression of Alzheimer’s disease

Moreno‐Rodríguez

Perez

Nadeem

et al. 2020

J Neuroinflammation

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Background: Chitinase 3-like 1 (CHI3L1), chitinase 3-like 2 (CHI3L2), and neuronal pentraxin II (NPTX2) are inflammatory biomarkers of Alzheimer's disease (AD). Although studies have demonstrated that cerebrospinal fluid levels of these proteins are changed in AD, no studies have undertaken a detailed examination of alterations in protein levels, cellular expression, and interaction with amyloid in the brain during the progression of AD. Methods:The study evaluated levels of both CHI3L1 and CHI3L2, NPTX2, ionized calcium-binding adapter molecule 1 (Iba1), complement component 1q (C1q), glial fibrillary acidic protein (GFAP), and CD44, in the frontal cortex of people who died with an antemortem clinical diagnosis of no cognitive impairment (NCI), mild cognitive impairment (MCI), mild/moderate AD (mAD), and severe AD (sAD) using immunoblot and immunohistochemical techniques.Results: CHI3L1-immunoreactive (-ir) astrocyte numbers were increased in the frontal cortex and white matter in sAD compared to NCI. On the other hand, increases in GFAP and Iba1-ir cell numbers were observed in MCI compared to NCI but only in white matter. Western blot analyses revealed significantly lower frontal cortex CHI3L2 levels, whereas CD44 levels were increased in sAD. No significant differences for CHI3L1, GFAP, C1q, and NPTX2 protein levels were detected between clinical groups. Strong significant correlations were found between frontal cortex CHI3L1 and Iba1-ir cell numbers in white matter and CHI3L1 and C1q protein levels in the early stages of the disease. C1q and Iba1, CD44 with CHI3L2, and GFAP protein levels were associated during disease progression. CHI3L1 and Iba1 cell numbers in white matter showed a significant associations with episodic memory and perceptual speed.Conclusions: White matter CHI3L1 inflammatory response is associated with cognitive impairment early in the onset of AD.

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“…40 Previous estimates of immunization rates have ranged widely (between 11% and 82%) depending on the populations and data collection methods used. [41][42][43][44][45] Our finding that CCHP-enrolled children had comparable documented immunization rates to children with other insurance before they enrolled in the program differs from previous reports showing lower immunization rates in uninsured children than in children with insurance. 46,47 The rates in our study may have been similar because of prior MK enrollment in some children or, in younger children, beneficial effects of the federal Vaccines For Children program that made free vaccine available to the uninsured in Colorado's private sector after 1995.…”

Section: Discussionmentioning

confidence: 86%

Quality of Care and Use of the Medical Home in a State-Funded Capitated Primary Care Plan For Low-Income Children

et al. 2000

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Despite capitated reimbursement for primary care services, CCHP provided children from low-income families with preventive, acute, and chronic care services of comparable quantity and quality to those received by children with MK or PI. The program was associated with a shift of immunization location to the primary care site and increased health maintenance care for new enrollees. CCHP-enrolled children used their medical home for the majority of acute health needs and were not high utilizers of emergency department or hospital services.

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Immunization Coverage Among Infants Enrolled in the Tennessee Medicaid Program

Cited by 18 publications

References 17 publications

Individual level determinants for not receiving immunization, receiving immunization with delay, and being severely underimmunized among rural western Kenyan children

Individual level determinants for not receiving immunization, receiving immunization with delay, and being severely underimmunized among rural western Kenyan children

Frontal cortex chitinase and pentraxin neuroinflammatory alterations during the progression of Alzheimer’s disease

Quality of Care and Use of the Medical Home in a State-Funded Capitated Primary Care Plan For Low-Income Children

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