Immunoadsorption in a dog with severe immune mediated hemolytic anemia

Richter, Petra; Fischer, Hendryk; Dörfelt, René

doi:10.1002/jca.21913

Cited by 2 publications

(3 citation statements)

References 17 publications

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“…There are only two case reports about IA in veterinary medicine. One case report showed a dog with immune-mediated hemolytic anemia successfully treated with IA, and the other one showed a dog with fulminant acquired myasthenia gravis successfully treated with IA [ 12 , 13 ]. The adsorption of IgG and IgM in the Ligasorb ® IA adsorber is unspecific.…”

Section: Discussionmentioning

confidence: 99%

Supportive Treatment of a Dog with Leishmaniosis and Severe Glomerulopathy with Immunoadsorption

Sänger,

Bergmann,

Hartmann

et al. 2024

Pathogens

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A three-year-old, intact female mix-breed dog, weighing 30 kg, was presented due to vomitus and diarrhea. At presentation, the patient had a slightly reduced general condition and moderately enlarged mandibular and popliteal lymph nodes. The initial blood work showed severe azotemia and hypoalbuminemia. In the urinalysis, marked proteinuria with a urine protein/creatinine ratio (UPC) of 4.69 was found. Further workup showed a high leishmania antibody titer. The dog was diagnosed with leishmaniosis and glomerulonephritis. Initial treatment consisted of intravenous fluid therapy, allopurinol, miltefosine, amlodipine, clopidogrel, and a diet with a low purine content. Creatinine temporarily decreased but increased again after three days. For further supportive treatment, intermittent hemodialysis in combination with hemoperfusion with the cytosorb® adsorber was performed. A total blood volume of 17.7 L was processed within three hours. Thereafter, immunoadsorption (IA) was performed with the COM.TEC® and ADAsorb® platforms and a LIGASORB® adsorber to eliminate circulating immunocomplexes. Treatment time for IA was two hours with a blood flow of 50 mL/min. A total plasma volume of 2.4 L was processed. Over the following days, creatinine declined, and the patient improved significantly. UPC decreased to 1.74 on day 17 after IA. The patient was discharged after two and a half weeks. Two years after the initial event, the patient is still in excellent condition, with creatinine, UPC, and albumin levels in the reference range. Therefore, IA might be an additional therapeutic option for dogs with leishmaniosis-induced glomerulonephritis and subsequent severe azotemia to improve immunocomplex-mediated glomerulonephritis.

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Section: Discussionmentioning

confidence: 99%

Supportive Treatment of a Dog with Leishmaniosis and Severe Glomerulopathy with Immunoadsorption

Sänger,

Bergmann,

Hartmann

et al. 2024

Pathogens

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“…In the veterinary literature, IA has yet not been described for the treatment of neurological disorders. A case report of successful treatment of a dog with immune-mediated hemolytic anemia is the only reference applying IA in dogs [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…The indication for IA is a severe myasthenic crisis, or before surgery in patients with thymoma [ 26 ]. In veterinary medicine, IA was successfully used in the management of immune-mediated hemolytic anemia in a dog [ 27 ]. To the best knowledge of the authors, IA has yet not been reported in the veterinary literature for the treatment of acquired MG.…”

Section: Introductionmentioning

confidence: 99%

Successful Emergency Management of a Dog with Ventilator-Dependent Acquired Myasthenia Gravis with Immunoadsorption

Sänger,

Dörfelt,

Giani

et al. 2023

Animals

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A one-year-old, female intact Samoyed, 12.5 kg, was presented with coughing for 2 weeks, progressive appendicular and axial muscle weakness, megaesophagus and labored breathing for 5 days. There was no improvement with standard treatment. Acquired myasthenia gravis was suspected and the dog was referred with increasing dyspnea. At presentation, the dog showed a severely reduced general condition, was non-ambulatory and showed abdominal and severely labored breathing. A marked hypercapnia (PvCO2 = 90.1 mmHg) was present in venous blood gas analysis. The serum anti-acetylcholine receptor antibody test was consistent with acquired myasthenia gravis (2.1 nmol/L). The dog was anesthetized with propofol and mechanically ventilated with a Hamilton C1 ventilator. Immunoadsorption was performed with the COM.TEC® and ADAsorb® platforms and a LIGASORB® adsorber to eliminate anti-acetylcholine receptor antibodies. Local anticoagulation was performed with citrate. Treatment time for immunoadsorption was 1.5 h with a blood flow of 50 mL/min. A total plasma volume of 1.2 L was processed. Further medical treatment included intravenous fluid therapy, maropitant, esomeprazole, antibiotic therapy for aspiration pneumonia and neostigmine 0.04 mg/kg intramuscularly every 6 h for treatment of acquired myasthenia gravis. Mechanical ventilation was stopped after 12 h. A percutaneous gastric feeding tube was inserted under endoscopic control on day 2 for further medical treatment and nutrition. A second treatment with immunoadsorption was performed on day 3. Again, a total plasma volume of 1.2 L was processed. Immediately after this procedure, the dog regained muscle strength and was able to stand and to walk. After 6 days, the dog was discharged from the hospital. This is the first report of immunoadsorption for emergency management of a dog with acute-fulminant acquired myasthenia gravis. Immunoadsorption may be an additional option for emergency treatment in dogs with severe signs of acquired myasthenia gravis.

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Immunoadsorption in a dog with severe immune mediated hemolytic anemia

Cited by 2 publications

References 17 publications

Supportive Treatment of a Dog with Leishmaniosis and Severe Glomerulopathy with Immunoadsorption

Supportive Treatment of a Dog with Leishmaniosis and Severe Glomerulopathy with Immunoadsorption

Successful Emergency Management of a Dog with Ventilator-Dependent Acquired Myasthenia Gravis with Immunoadsorption

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