Immunoassays based on inductively coupled plasma mass spectrometry detection: So far so good, so what?

Atomic spectrometry update: review of advances in the analysis of clinical and biological materials, foods and beverages

“…Element tagging for immunoassay readout with ICP-MS has gained popularity over recent years and methodological developments are summarised in two review articles. 9,11 Numerous immunoassay formats have been evaluated, primarily using REE and transition metals with various signal amplications strategies. While elemental MS detection can offer technological advantages for immunoassays in terms of LOD and multiplexing capability, instrumentation remains relatively complex compared to automated readout methods such as uorescence, chemiluminescence and electrochemiluminescence.…”

“…Element-tagged immunoassays to date are tabulated in the review by Torregrosa et al 9 and many have targeted tumour marker analysis. This review period was no different with proposed assays for CA19-9, CEA, AFP and hCG.…”

“…The number of such papers has gradually increased and these assays are now featuring in review articles. With a title including the intriguing phrase ‘So far, so good, so what?’, Grindlay and colleagues 9 expanded on the techniques and applications, emphasising the advantages of high diagnostic sensitivity and selectivity, multiplexed capabilities, large dynamic range and robustness for the analysis of both liquid and solid samples. They lamented, however that immunoassays based on ICP-MS are poorly recognised among the life sciences.…”

Atomic spectrometry update: review of advances in atomic spectrometry and related techniques

“…Feng et al 11 reviewed (68 references) research related to metallomics but made no suggestions as to the current efficacy for routine clinical diagnosis. Arguably the most insightful analysis of the current status of this research area was that of Torregrosa et al 12 who presented an overview (97 references) summarising immunoassays based on ICP-MS detection of liquid and solid samples. They made the important point that no real breakthrough has yet appeared which makes this approach viable for routine clinical analysis, and went on to itemise the advances which are required for: analytes other than macromolecules, such as haptens; conjugation strategies for elemental tagging, particularly involving NPs; the advantages of using aptamers rather than antibodies; multiplexing; analysis of solid samples; and advances in instrumentation such as ICP-TOFMS and spICP-MS.…”

Diamond-Based Electrodes for Detection of Metal Ions and Anions

“…A number of methods involving organic nanoprobes, covalent–organic frameworks (COFs), metal–organic frameworks (MOFs), metal nanoparticles, hybrid nanomaterials, small molecules, and polymers were engaged in the quantitation of specific analytes [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ]. On the other end of the spectrum, instrumental tactics, such as inductively coupled plasma mass spectrometry, high-performance liquid chromatography, gas chromatography, atomic absorption spectrometry, electrochemical studies, and immunoassays have been pronounced as the conventional cost-effective approaches [ 14 , 15 , 16 , 17 , 18 , 19 , 20 ]. Among them, electrochemical-based detection of specified analyte detection seems to be impressive in terms of its selectivity and sensitivity with lower detection/quantification limits [ 21 , 22 , 23 ].…”