Immunochemical studies on the excretion of T-2 toxin metabolites in rat and cynomolgus monkey urine

Lee, Rachel C; Bunner, David L.; Wannemacher, Robert W.; Chu, Fun Sun

doi:10.1021/jf00092a024

Cited by 5 publications

(1 citation statement)

References 25 publications

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“…Competitive ELISA containing a generic antibody against type A trichothecenes was developed as a tool for determination of T-2 and its metabolites in urine of rats and cynomolgus monkey (Lee et al, 1990). This kit was successfully used for assessment of T-2 exposure in both investigated animal species.…”

Section: Immunochemical Methodsmentioning

confidence: 99%

Scientific Opinion on the risks for animal and public health related to the presence of T-2 and HT-2 toxin in food and feed

2011

EFSA Journal

281

102

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T-2 toxin and HT-2 toxin are mycotoxins produced by various Fusarium species. The European Commission asked EFSA for a scientific opinion on the risk to human and animal health related to the presence of T-2 and HT-2 toxin in food and feed. A total of 20,519 results for the sum of T-2 and HT-2 toxins in food, feed and unprocessed grains, collected in 2005-2010 from 22 European countries, were used in the evaluation. The highest mean concentrations for the sum of T-2 and HT-2 toxins were observed in grains and grain milling products, notably in oats and oat products. Grains and grain-based foods, in particular bread, fine bakery wares, grain milling products, and breakfast cereals, made the largest contribution to the sum of T-2 and HT-2 toxin exposure for humans. T-2 toxin is rapidly metabolised to a large number of products, HT-2 toxin being a major metabolite. Pigs are amongst the most sensitive animals towards the effects of T-2 toxin, the most sensitive endpoints being immunological or haematological effects. Using these data and a benchmark dose analysis the Panel on Contaminants in the Food Chain established a group tolerable daily intake (TDI) of 100 ng/kg b.w. for the sum of T-2 and HT-2 toxins. Estimates of chronic human dietary exposure to the sum of T-2 and HT-2 toxins based on the available occurrence data are below the TDI for populations of all age groups, and thus not a health concern. For ruminants, rabbits and farmed fish the estimated exposures to the sum of these toxins based on the available occurrence data are considered unlikely to be a health concern, while for pigs, poultry, dogs and horses the risk of adverse health effects is low. For cats the health risk from the exposure to T-2 and HT-2 toxins cannot be assessed.

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Section: Immunochemical Methodsmentioning

confidence: 99%