Immunogenen Zelltod induzierende Metallkomplexe für die Krebstherapie

Zhang, Lingpu; Montesdeoca, Nicolás; Karges, Johannes; Xiao, Haihua

doi:10.1002/ange.202300662

Cited by 3 publications

References 68 publications

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The Development of Metal‐Based Antioxidants as Anticancer Agents

Nilewar,

Afroz,

Dunn

et al. 2023

Encyclopedia of Inorganic and Bioinorganic Chemistry

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Cancer continues to be a worldwide challenge for therapeutic design. Metal complexes have played a strong role as anticancer agents and they continue to be explored thanks to their versatility and success to date. Recent studies have shown that delivery of an antioxidant concomitant to chemotherapy enhances positive patient outcomes. While metal complexes with antioxidant activity are abundant, the number of studies of such compounds with anticancer activity is low. As a result of this and other studies, dual‐acting antioxidant and anticancer agents are gaining interest. Examples of these studies are presented focusing on the coordination chemistry, anticancer results, and antioxidant mechanisms for complexes reported since 2015.

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The Development of Metal‐Based Antioxidants as Anticancer Agents

Nilewar,

Afroz,

Dunn

et al. 2023

Encyclopedia of Inorganic and Bioinorganic Chemistry

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Localization of Cancer Cells for Subsequent Robust Photodynamic Therapy by ROS Responsive Polymeric Nanoparticles With Anti‐Metastasis Complexes NAMI‐A

Zhang,

Cui,

Tang

et al. 2024

Advanced Materials

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Photodynamic therapy (PDT), as a new type of light‐mediated reactive oxygen species (ROS) cancer therapy, has the advantages of high therapeutic efficiency, non‐resistance, and less trauma than traditional cancer therapy such as surgery, radiotherapy, and chemotherapy. However, oxygen‐dependent PDT further exacerbates tumor metastasis. To this end, a strategy that circumvents tumor metastasis to improve the therapeutic efficacy of PDT is proposed. Herein, a near‐infrared light‐activated photosensitive polymer is synthesized and branched the anti‐metastatic ruthenium complex NAMI‐A on the side, which is further assembled to form nanoparticles (NP2) for breast cancer therapy. NP2 can kill tumor cells by generating ROS under 808 nm radiation (NP2 + L), reduce the expression of matrix metalloproteinases (MMP2/9) in cancer cells, decrease the invasive and migration capacity of cancer cells, and eliminate cancer cells. Further animal experiments show that NP2 + L can inhibit tumor growth and reduce liver and lung metastases. In addition, NP2 + L can activate the immune system in mice to avoid tumor recurrence. In conclusion, a PDT capable of both preventing tumor metastasis and precisely hitting the primary tumor to achieve effective treatment of highly metastatic cancers is developed.

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Cytotoxic Activities of Half‐sandwich M(III) Complexes (M=Rh, Ir) Bearing Chloro‐substituted Bidentate‐coordinated Phenanthroline or Terpyridine Ligands

Graf

Ochs

Metzler‐Nolte

et al. 2023

Zeitschrift anorg allge chemie

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The synthesis and characterization of four compounds [M(η5‐C5Me5)(N^N)Cl]PF6 [N^N=4,7‐dichloro‐1,10‐phenanthroline with M=Rh, 1, and M=Ir, 2, and N^N=4'‐(4‐chlorophenyl)‐2,2':6',2''‐terpyridine in the κ2N,N'‐coordination mode with M=Rh, 3, and M=Ir, 4] are described. All compounds were characterized by spectroscopic means and their molecular structures in the crystal were confirmed by single‐crystal X‐ray diffraction studies. The cytotoxicity of all compounds was evaluated by MTT assay against the three cancer cell lines HeLa (cervical carcinoma), HT‐29 (colon adenocarcinoma) and MCF‐7 (human breast adenocarcinoma). The complexes 3 and 4 display promising activity with IC50 values of 1 μM. The rhodium(III) complex 1 also shows highly improved cytotoxicity compared to cisplatin against the cancer cell lines HT‐29 and MCF‐7. In contrast to this, the iridium(III) complex 2 is even less active against the HeLa cell line than cisplatin.

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Immunogenen Zelltod induzierende Metallkomplexe für die Krebstherapie

Cited by 3 publications

References 68 publications

The Development of Metal‐Based Antioxidants as Anticancer Agents

The Development of Metal‐Based Antioxidants as Anticancer Agents

Localization of Cancer Cells for Subsequent Robust Photodynamic Therapy by ROS Responsive Polymeric Nanoparticles With Anti‐Metastasis Complexes NAMI‐A

Cytotoxic Activities of Half‐sandwich M(III) Complexes (M=Rh, Ir) Bearing Chloro‐substituted Bidentate‐coordinated Phenanthroline or Terpyridine Ligands

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