Immunogenic sonodynamic therapy for inducing immunogenic cell death and activating antitumor immunity

Wang, Ting; Peng, Wangrui; Du, Mingliang; Chen, Zhiyi

doi:10.3389/fonc.2023.1167105

Cited by 14 publications

(5 citation statements)

References 66 publications

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“…Taking into account the inherent immunostimulatory properties of bacteria and the potential of SDT in activating immune responses, [ 50,51 ] we conducted a thorough investigation to elucidate the underlying mechanisms responsible for the remarkably enhanced therapeutic effect achieved by E. coli ‐pE@PCN‐mediated SDT. Mice bearing CT26 tumors were randomly assigned to five groups and subjected to identical treatments as described above.…”

Section: Resultsmentioning

confidence: 99%

Programmable Bacteria‐Based Biohybrids as Living Biotherapeutics for Enhanced Cancer Sonodynamic‐Immunotherapy

Wang,

Chen,

Zhu

et al. 2024

Adv Funct Materials

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Synthetic biology is propelling medicine into a new era through its capacity to genetically program living cells. One of the particular interests is engineering bacteria as a live and targeted therapeutic delivery system. Herein, the bacterial biohybrid (E. coli‐pE@PCN) is developed by genetically engineering Escherichia coli BL21 to overexpress catalase (E. coli‐pE) and electrostatically adsorbing nano‐sonosensitizers (PCN NPs) for enhanced and targeted sonodynamic therapy (SDT). Leveraging the ability to colonize and penetrate deep in tumors, engineered bacteria can not only sustainably express catalase to relieve tumor hypoxia, but also facilitate the enriched and expanded distribution of the carried sonosensitizer at the tumor site, so as to trigger effective SDT. More interestingly, it is found that E. coli‐pE@PCN‐based SDT can successfully inhibit the growth of subcutaneous and orthotopic colorectal tumors by inducing potent antitumor immune responses due to the released tumor‐associated antigens and native immunogenicity of bacterial pathogen‐associated molecular patterns. Furthermore, E. coli‐pE@PCN‐based SDT can not only prime a strong immune memory response to prevent tumor recurrence but also elicit a potent abscopal effect to inhibit tumor metastasis. Therefore, the programmable bacteria‐based biohybrids developed here pave an avenue to prepare next‐generation sonodynamic‐immunotherapeutics to eliminate cancer and prevent its relapse and metastasis.

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Section: Resultsmentioning

confidence: 99%

Programmable Bacteria‐Based Biohybrids as Living Biotherapeutics for Enhanced Cancer Sonodynamic‐Immunotherapy

Wang,

Chen,

Zhu

et al. 2024

Adv Funct Materials

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“…Such techniques not only improve therapeutic efficacy, but also help to establish immune memory and reduce the risk of tumor recurrence. [ 48 ]…”

Section: Physical Therapy Combined With Immunotherapymentioning

confidence: 99%

Nanotechnology‐Empowered Combination Cancer Immunotherapies: Mechanisms, Synergies, and Perspectives

Pan,

Xue,

Liang

2024

Advanced NanoBiomed Research

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This review is aiming to systematically elucidate the unique role of nanotechnology in optimizing therapeutic modalities for combinatorial cancer immunotherapy, which enables the synergistic integration of multiple treatment strategies. In particular, nanotechnology has enabled the synergistic combination of immunotherapy with physical therapies, chemotherapy, metal therapy, and nucleic acid therapy. In each combination regimen, nanocarriers play multifaceted roles by achieving targeted codelivery of different therapeutics and optimizing each individual treatment modality. This offers new paradigms to guide precision medicine in cancer treatment. Immunotherapy alone is unlikely to achieve personalized precision medicine for cancer, and new treatment modalities are needed in the future. To overcome technical bottlenecks and realize precise regulation of the tumor microenvironment for personalized cancer treatment, it is crucial to develop novel nanosystems with integrated sensing, targeting, and therapeutic functionalities.

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“…SDT effectively eradicates tumor cells, triggering the induction and release of tumorassociated antigens (TAAs) and generating damage-associated molecular patterns (DAMPs). These DAMPs include calreticulin (CRT) exposed on the cell surface, high-mobility group protein 1 (HMGB1) secreted from the tumor cells, and ATP and heat shock proteins (HSP70, HSP90) released by the cells [29]. In traditional antitumor therapies such as chemotherapy or radiotherapy, apoptosis in tumor cells often leads to the release of DAMPs.…”

Section: Mechanisms Of Icd Inductionmentioning

confidence: 99%

Application of Nanomaterial-Based Sonodynamic Therapy in Tumor Therapy

Yang,

Li,

et al. 2024

Pharmaceutics

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Sonodynamic therapy (SDT) has attracted significant attention in recent years as it is an innovative approach to tumor treatment. It involves the utilization of sound waves or ultrasound (US) to activate acoustic sensitizers, enabling targeted drug release for precise tumor treatment. This review aims to provide a comprehensive overview of SDT, encompassing its underlying principles and therapeutic mechanisms, the applications of nanomaterials, and potential synergies with combination therapies. The review begins by introducing the fundamental principle of SDT and delving into the intricate mechanisms through which it facilitates tumor treatment. A detailed analysis is presented, outlining how SDT effectively destroys tumor cells by modulating drug release mechanisms. Subsequently, this review explores the diverse range of nanomaterials utilized in SDT applications and highlights their specific contributions to enhancing treatment outcomes. Furthermore, the potential to combine SDT with other therapeutic modalities such as photothermal therapy (PTT) and chemotherapy is discussed. These combined approaches aim to synergistically improve therapeutic efficacy while mitigating side effects. In conclusion, SDT emerges as a promising frontier in tumor treatment that offers personalized and effective treatment options with the potential to revolutionize patient care. As research progresses, SDT is poised to play a pivotal role in shaping the future landscape of oncology by providing patients with a broader spectrum of efficacious and tailored treatment options.

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Immunogenic sonodynamic therapy for inducing immunogenic cell death and activating antitumor immunity

Cited by 14 publications

References 66 publications

Programmable Bacteria‐Based Biohybrids as Living Biotherapeutics for Enhanced Cancer Sonodynamic‐Immunotherapy

Programmable Bacteria‐Based Biohybrids as Living Biotherapeutics for Enhanced Cancer Sonodynamic‐Immunotherapy

Nanotechnology‐Empowered Combination Cancer Immunotherapies: Mechanisms, Synergies, and Perspectives

Application of Nanomaterial-Based Sonodynamic Therapy in Tumor Therapy

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