Immunogenicity of biliary epithelium: Study of the adhesive interaction with lymphocytes

Mp, Leon; Bassendine, MF; Gibbs, Paul; Thick, Michael; Kirby, John A.

doi:10.1053/gast.1997.v112.pm9041260

Cited by 55 publications

(35 citation statements)

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“…The biological process of integrin-mediated cell matrix adhesion, genes involved in which were down-regulated in HCC-infiltrating mononuclear inflammatory cells, may suggest that these cells were able to remigrate into the microcirculation with the enriched blood flow in HCC tissues. The process of integrin-mediated cell matrix adhesion in HCC-infiltrating inflammatory cells may imply weaker adhesion of infiltrating mononuclear inflammatory cells to cancer tissues compared with noncancerous liver tissues (48). PBMCs are also presumed to be affected by humoral factors from HCC tissues (49).…”

Section: Discussionmentioning

confidence: 99%

Common Transcriptional Signature of Tumor-Infiltrating Mononuclear Inflammatory Cells and Peripheral Blood Mononuclear Cells in Hepatocellular Carcinoma Patients

et al. 2008

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Hepatocellular carcinoma (HCC) is frequently associated with infiltrating mononuclear inflammatory cells. We performed laser capture microdissection of HCC-infiltrating and noncancerous liver-infiltrating mononuclear inflammatory cells in patients with chronic hepatitis C (CH-C) and examined gene expression profiles. HCC-infiltrating mononuclear inflammatory cells had an expression profile distinct from noncancerous liver-infiltrating mononuclear inflammatory cells; they differed with regard to genes involved in biological processes, such as antigen presentation, ubiquitin-proteasomal proteolysis, and responses to hypoxia and oxidative stress. Immunohistochemical analysis and gene expression databases suggested that the up-regulated genes involved macrophages and Th1 and Th2 CD4 cells. We next examined the gene expression profile of peripheral blood mononuclear cells (PBMC) obtained from CH-C patients with or without HCC. The expression profiles of PBMCs from patients with HCC differed significantly from those of patients without HCC (P < 0.0005). Many of the up-regulated genes in HCCinfiltrating mononuclear inflammatory cells were also differentially expressed by PBMCs of HCC patients. Analysis of the commonly up-regulated or down-regulated genes in HCCinfiltrating mononuclear inflammatory cells and PBMCs of HCC patients showed networks of nucleophosmin, SMAD3, and proliferating cell nuclear antigen that are involved with redox status, the cell cycle, and the proteasome system, along with immunologic genes, suggesting regulation of anticancer immunity. Thus, exploring the gene expression profile of PBMCs may be a surrogate approach for the assessment of local HCC-infiltrating mononuclear inflammatory cells.

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Section: Discussionmentioning

confidence: 99%

Common Transcriptional Signature of Tumor-Infiltrating Mononuclear Inflammatory Cells and Peripheral Blood Mononuclear Cells in Hepatocellular Carcinoma Patients

et al. 2008

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“…There is a consensus that they can bind immune effector cells in vitro resulting in efficient cytolysis. 8 This has led to development of a model in which VBDS is seen as the consequence of IBEC death, the void produced by epithelial loss becoming populated by activated fibroblasts. Recent studies suggest that a number of cell types within the liver can undergo transition to become myofibroblasts capable of matrix synthesis during fibrogenesis.…”

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confidence: 99%

Epithelial–mesenchymal transition contributes to portal tract fibrogenesis during human chronic liver disease

Rygiel

Robertson

Marshall

et al. 2008

Laboratory Investigation

214

189

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“…At least 50% of the overall interaction is dependent on LFA-1 on cytotoxic T-lymphocytes, which is the ligand for ICAM-1 expressed on BEC. BEC are also susceptible to lysis by cytokine-activated natural killer (NK) cells (Leon et al, 1997). In the presence of antigen in association with MHC molecules, the lymphocytes would become activated to recognize BEC as a potential target and expression of adhesion molecules would then render them susceptible to cytolytic mechanisms by attracting cytotoxic T lymphocytes (CTL).…”

Section: Immune Response Role-expression Of Adhesion Moleculesmentioning

confidence: 99%

A Review of the Physiological and Immunological Functions of Biliary Epithelial Cells: Targets for Primary Biliary Cirrhosis, Primary Sclerosing Cholangitis and Drug‐induced Ductopenias

Davis

Luketic

et al. 2004

Journal of Immunology Research

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Our understanding of biliary epithelial cells (BEC) in physiobiology and immunology has steadily expanded. BEC transports IgA as well as IgM into bile, synthesizes and secretes various chemokines, cytokines, and expresses adhesion molecules involved in cell interaction and signal transduction. These then suggest a myriad of potential roles for BEC in defense from invading microorganisms as well as the pathogenesis of diverse immunologically driven diseases such as primary biliary cirrhosis (PBC), graft-versus-host disease, and primary sclerosing cholangitis (PSC). Despite the progress, there still remain many areas of BEC biology that require further investigation. Most importantly, it remains to be clarified that the extent to which the immunologic activities observed in BEC represent a BEC response to tissue injury or whether BEC themselves are the active participants in the pathogenesis of various cholestatic immunological diseases, including PBC and PSC.

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Immunogenicity of biliary epithelium: Study of the adhesive interaction with lymphocytes

Cited by 55 publications

References 1 publication

Common Transcriptional Signature of Tumor-Infiltrating Mononuclear Inflammatory Cells and Peripheral Blood Mononuclear Cells in Hepatocellular Carcinoma Patients

Common Transcriptional Signature of Tumor-Infiltrating Mononuclear Inflammatory Cells and Peripheral Blood Mononuclear Cells in Hepatocellular Carcinoma Patients

Epithelial–mesenchymal transition contributes to portal tract fibrogenesis during human chronic liver disease

A Review of the Physiological and Immunological Functions of Biliary Epithelial Cells: Targets for Primary Biliary Cirrhosis, Primary Sclerosing Cholangitis and Drug‐induced Ductopenias

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