Immunogenicity of recombinant Bacillus strains with a cloned gene for synthesis of the protective antigen of Bacillus anthracis

Микшис, Н. И.; Кудрявцева, О. М.; Bolotnikova, M. F.; Shulepov, D. V.; Novikova, L. V.; Popov, Yu. A.; Щуковская, Т. Н.; Drozdov, I. G.; Кутырев, Владимир

doi:10.3103/s0891416807030032

Cited by 4 publications

(5 citation statements)

References 24 publications

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“…In bacteriophage transduction of genes between different bacterial hosts, typically only the donor genes are recombined into the host's genome, so any identifiable signature of the bacteriophage vector is absent. Modification of the biothreat agent Bacillus anthracis by such "stealth" bacteriophage recombination has been demonstrated (Pomerantsev et al, 2006;Mikshis et al, 2007).…”

Section: Non-identifiable and Non-attributable Bioweaponsmentioning

confidence: 99%

The future of biosecurity

Campbell¹

2009

IJRAM

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The future of biosecurity will be determined by international scientific and political responses to the rapid worldwide expansion of genetic engineering technologies in infectious disease research, and by implementation of cooperative global surveillance and public health response policies to control the emergence of new strains of natural disease organisms. Effective responses will depend on a better understanding of the forces driving molecular evolution of emerging pathogens, as well as an integrated understanding of advanced biothreat agent design, potential applications and effects of the agent, exposure techniques or methods of deployment, and concealment techniques, including dual use stratagems.

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Section: Non-identifiable and Non-attributable Bioweaponsmentioning

confidence: 99%

The future of biosecurity

Campbell¹

2009

IJRAM

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“…78 Construction of recombinant B. anthracis strains carrying the plasmid pUB110PA-1 that provided stable expression of the PA, and were capable of protecting guinea pigs against experimental anthrax after a single immunization has also been described. 79 …”

Section: Future Prospects For Russian Vaccines Against Edpsmentioning

confidence: 99%

Russian vaccines against especially dangerous bacterial pathogens

Feodorova

Sayapina

Corbel

et al. 2014

Emerging Microbes & Infections

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In response to the epidemiological situation, live attenuated or killed vaccines against anthrax, brucellosis, cholera, glanders, plague and tularemia were developed and used for immunization of at-risk populations in the Former Soviet Union. Certain of these vaccines have been updated and currently they are used on a selective basis, mainly for high risk occupations, in the Russian Federation. Except for anthrax and cholera these vaccines currently are the only licensed products available for protection against the most dangerous bacterial pathogens. Development of improved formulations and new products is ongoing.

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“…ПА выделяли из штамма B. anthracis 55∆ТПА-1(Spo -). Антиген очищали двухэтапной хроматографией, как описано ранее [2]. Подготовку споровой взвеси штаммов В. anthracis осуществляли по стандартной методике [3].…”

Section: материалы и методыunclassified

“…В РосНИПЧИ «Микроб» на основе бесплазмидных производных вакцинных штаммов B. anthracis СТИ-1 и B. anthracis 55 были сконструированы рекомбинантные штаммы, лишенные детерминант синтеза основных факторов патогенности сибиреязвенного микроба, но содержащие ген pag, кодирующий синтез ПА [2,3].…”

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Peculiarities of Antibody Genesis in the Laboratory Animals Immunized with Anthrax Protective Antigen Preparation, <i>Bacillus anthracis</i> Recombinant or <i>Bacillus anthracis</i> Vaccine Strains

Popova

Микшис

Goncharova

et al. 2012

Problemy Osobo Opasnykh Infektsii

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Protective antigen, extracted from Bacillus anthracis asporogenic recombinant strain, triggers progression of a high-grade adaptive immunity in vivo. Twofold immunization of rabbits with the purified protein preparation in a dose of 50 mcg induces production of specific antibodies in titers higher than those registered in case of immunization with vaccine or genetically engineered anthrax strains. It is determined that the recombinant B. anthracis strain initiates further production of antibodies towards S-layer protein of anthrax agent.

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Immunogenicity of recombinant Bacillus strains with a cloned gene for synthesis of the protective antigen of Bacillus anthracis

Cited by 4 publications

References 24 publications

The future of biosecurity

The future of biosecurity

Russian vaccines against especially dangerous bacterial pathogens

Peculiarities of Antibody Genesis in the Laboratory Animals Immunized with Anthrax Protective Antigen Preparation, <i>Bacillus anthracis</i> Recombinant or <i>Bacillus anthracis</i> Vaccine Strains

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