Immunoglobulin allotypes and IgG subclass antibody response to Aspergillus fumigatus in cystic fibrosis patients

Skov, Marianne; Pandey, Janardan P.; Pressler, T.; Høiby, Niels; Koch, Christian

doi:10.1016/j.jcf.2004.05.048

Cited by 14 publications

(10 citation statements)

References 35 publications

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“…3 Age data for 20 adult controls shown, age data missing from 20 controls, but all were under 18 years of age. 4 Sex data missing from 10/40 controls. 5 Mutation in the cystic fibrosis transmembrane conductance regulator gene.…”

Section: Discussionmentioning

confidence: 99%

“…A serological test could potentially guide disease management, a principle which is in use for other CF pathogens. [3][4][5][6][7][8] Relying on serology alone to diagnose chronic infection in CF is not sufficient, 9 but combining antibody measurements with culture results can yield simultaneously good sensitivity and specificity. 10 One approach is to comprehensively screen CF populations for antibodies and then reserve frequent sputum culturing for those, who are antibody positive.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of a bovine antibody test for diagnosingMycobacterium aviumcomplex in patients with cystic fibrosis

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of a bovine antibody test for diagnosingMycobacterium aviumcomplex in patients with cystic fibrosis

et al. 2016

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“…It was reported that elevated serum concentrations of IgG4 is sometimes observed in severe asthma (14), but it was not observed in mild or typical asthma (15). Anti-aspergillus fumigatus IgG4-antibodies were detected in the patients with allergic bronchopulmonary aspergillosis complicated with cystic fibrosis (16). It will be necessary to comprehensively analyze IgG subclasses in other disorders, but it is traditionally suggested that the IgG4 is concerned with allergy (17,18).…”

Section: F I G U R E 2 T H E R E N a L S P E C I Me N Wi T H A N T mentioning

confidence: 99%

Analysis of Serum IgG Subclasses in Churg-Strauss Syndrome -The Meaning of Elevated Serum Levels of IgG4

et al. 2010

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Objective Mikulicz's disease (MD) is characterized by symmetrical and persistent enlargement of the lacrimal and salivary glands. Recently it has been categorized as an 'Ig (immunoglobulin) G4-related disease.' It presents with elevated serum levels of IgG4 and abundant infiltration of IgG4-bearing plasmacytes in involved organs. Allergic symptoms are often observed in patients with IgG4-related disease. On the other hand, allergic diseases are often complicated with Churg-Strauss syndrome (CSS). Here we focused on CSS and analyzed the relation of IgG4 in its pathogenesis. Materials and MethodsWe analyzed five patients (2 men and 3 women) with CSS and 51 patients (20 men and 31 women) with MD who presented at Sapporo Medical University Hospital since 2001. We measured the serum concentrations of IgG subclasses in the patients with MD and CSS, and evaluated renal specimens from CSS patients, staining them for anti-IgG4 antibody. Results We surprisingly found elevated serum levels of IgG4 not only in MD but also in CSS patients. The renal specimens in CSS patients revealed the infiltration of IgG4-positive plasmacytes. Conclusion IgG4-bearing plasmacytes may be involved in the pathogenesis of CSS, and it is possible that an allergic reaction plays an important role in the pathogenesis of IgG4-related disease.

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“…Patients with CF are followed closely for their entire lives and there might be a benefit in using serodiagnosis as a complement to routine culture, in the same way that antibodies against Pseudomonas aeruginosa and Aspergillus are used successfully in many CF centres [15][16][17][18][19]. Limitations in the predictive values of such assays have been reported [20], and currently antibody measurements for P. aeruginosa are used clinically in combination with culture results, rather than as stand-alone tests [21].…”

Section: Introductionmentioning

confidence: 99%

Serodiagnosis ofMycobacterium abscessuscomplex infection in cystic fibrosis

et al. 2015

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Early signs of pulmonary disease with Mycobacterium abscessus complex (MABSC) can be missed in patients with cystic fibrosis (CF). A serological method could help stratify patients according to risk. The objective of this study was to test the diagnostic accuracy of a novel method for investigating IgG activity against MABSC.A prospective study of all patients attending the Copenhagen CF Centre was conducted by culturing for MABSC during a 22-month period and then screening patients with an anti-MABSC IgG ELISA. Culturepositive patients had stored serum examined for antibody kinetics before and after culture conversion.307 patients had 3480 respiratory samples cultured and were then tested with the anti-MABSC IgG ELISA. Patients with MABSC pulmonary disease had median anti-MABSC IgG levels six-fold higher than patients with no history of infection (434 versus 64 ELISA units; p<0.001). The test sensitivity was 95% (95% CI 74-99%) and the specificity was 73% (95% CI 67-78%). A diagnostic algorithm was constructed to stratify patients according to risk.The test accurately identified patients with pulmonary disease caused by MABSC and was suited to be used as a complement to mycobacterial culture. @ERSpublications Measuring antibodies against Mycobacterium abscessus can identify patients who harbour this emerging threat to health

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Immunoglobulin allotypes and IgG subclass antibody response to Aspergillus fumigatus in cystic fibrosis patients

Abstract: An influence of the GM allotypes on the immune response to Af. and on the development of ABPA in patients with CF is suggested.

Cited by 14 publications

References 35 publications

Evaluation of a bovine antibody test for diagnosingMycobacterium aviumcomplex in patients with cystic fibrosis

Evaluation of a bovine antibody test for diagnosingMycobacterium aviumcomplex in patients with cystic fibrosis

Analysis of Serum IgG Subclasses in Churg-Strauss Syndrome -The Meaning of Elevated Serum Levels of IgG4

Serodiagnosis ofMycobacterium abscessuscomplex infection in cystic fibrosis

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