Immunoglobulin E, Interleukin-18 and Interleukin-12 in Patients with Atopic Dermatitis: Correlation with Disease Activity

Zedan, Khaled

doi:10.7860/jcdr/2015/12261.5742

Cited by 34 publications

(38 citation statements)

References 30 publications

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“…Elevated expression of serum IL‐18 is seen in children and murine models . It has been shown to be elevated in the SC of adults with AD and in the serum of infants and children with AD, correlating with disease activity . We also found CXCL8 (IL‐8) to be significantly increased in the SC and correlated with disease severity and barrier dysfunction, further supporting the role of innate activation.…”

Section: Discussionsupporting

confidence: 64%

Systemic and stratum corneum biomarkers of severity in infant atopic dermatitis include markers of innate and T helper cell‐related immunity and angiogenesis

McAleer

Jakaša

Hurault³

et al. 2018

Br J Dermatol

143

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Section: Discussionsupporting

confidence: 64%

Systemic and stratum corneum biomarkers of severity in infant atopic dermatitis include markers of innate and T helper cell‐related immunity and angiogenesis

McAleer

Jakaša

Hurault³

et al. 2018

Br J Dermatol

143

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“…The IgE sensitization and severity of many atopic disorders were well studied and connected with each other particularly for AD progression and BA persistence (23,24). Previously we also concluded that IgE is useful in evaluating the progression of AD and in elucidating the mechanisms of disease pathogenesis (6). In this study, we found that the serum levels of total IgE in patients with different atopic disorders were significantly higher as compared with healthy controls.…”

Section: Discussionsupporting

confidence: 51%

“…To prove this hypothesis, we determined the serum levels of filaggrin protein in patients with BA, AR, AD and also in those atopic patients, which were affected by multiple atopic disorders (mixed atopic patients). Not only have we measured these, we also determined the levels of IgE as a positive control for the allergic patients as studies have shown a well-defined association between serum IgE levels with allergic disorders (5,6). Bronchial hyperactivity has long been recognized as a hallmark of a number of allergic disorders but it's association with the dysfunctioning of mast cells and eosinophils is still not completely defined and remains controversial (7,8).…”

mentioning

confidence: 99%

Filaggrin, major basic protein and leukotriene B4: Biomarkers for adult patients of bronchial asthma, atopic dermatitis and allergic rhinitis

Rasheed

Salama

et al. 2018

IRDR

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Bronchial asthma (BA), atopic dermatitis (AD) and allergic rhinitis (AR) are common atopic disorders with complicated etiologies. The atopic march from early AD to BA, AR, or both later in life and the extensive comorbidity among them indicates, that these atopic disorders might share a common mechanism (1). Moreover, heritability of these atopic disorders is high, being 35-95% for BA, 71-84% for AD, 33-91% for AR and 34-68% for allergen-specific serum immunoglobulin E (IgE) levels (1,2). Filaggrin is now considered as a major predisposing gene for many atopic disorders, which result in a major paradigm in dermatology and allergy research (3). Many studies pointed out an association of the filaggrin gene with different atopic disorders. More specifically, loss-of-function mutations in the filaggrin gene have been reported to have an association with various atopic/allergic disorders (3). Batchelor et al., reported that there is a strong and consistent association between filaggrin mutations and development of AD (4), but Summary Bronchial asthma (BA), atopic dermatitis (AD), and allergic rhinitis (AR) are well known atopic disorders with complex etiologies. This study was undertaken to investigate the role of filaggrin, eosinophil major basic protein (MBP) and leukotriene B4 (LTB4) in patients with BA, AD, and AR. Sera from 1,246 patients with different atopic disorders and 410 normal healthy controls were collected and were evaluated for filaggrin, MBP and LTB4 by specific sandwich ELISAs, whereas immunoglobulin E (IgE) was used as a positive control for atopic patients. Serum analysis showed that filaggrin levels were remarkably high in patients with AD and in patients with multiple (mixed) atopic disorders (p < 0.001), whereas its levels in BA and AR patients were low but much higher than in normal human sera (p < 0.01). MBP levels were also high in AR, BA and mixed atopic patients, whereas AD patients showed no increase of MBP (p > 0.05). In contrast, LTB4 level was found to be significantly low in all tested atopic patients groups as compared to the levels of LTB4 present in normal human sera (p < 0.001). In conclusion, these findings support an association between filaggrin, MBP or LTB4 and atopic disorders. Our data strongly suggest that filaggrin, MBP or LTB4 might be useful in elucidating the mechanisms involved in the pathogenesis of these atopic disorders.

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“…Monocyte-derived dendritic cells induced by Malassezia furfur in peripheral blood stimulate the production of IL-18 in addition to that of TNF-α and IL-1β [ 54 ]. Additionally, Zedan et al [ 55 ], reported that AD severity (SCORAD score) correlates with the serum IL-18 concentration. Furthermore, chronic stress suppresses the HPA axis and aggravates Th2 immune responses with the lack of immunosuppressive effects in allergic diseases [ 56 ].…”

Section: Il-18 In Inflammatory and Autoimmune Cutaneous Diseasesmentioning

confidence: 99%

IL-18 and Cutaneous Inflammatory Diseases

Lee

Cho

Park

2015

IJMS

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Interleukin (IL)-18, an IL-1 family cytokine, is a pleiotropic immune regulator. IL-18 plays a strong proinflammatory role by inducing interferon (IFN)-γ. Previous studies have implicated IL-18 in the pathogenesis of various diseases. However, it is not well understood biologic activities of IL-18 in the diverse skin diseases. Here, we have reviewed the expression and function of IL-18 in skin diseases including inflammatory diseases. This article provides an evidence-based understanding of the role of IL-18 in skin diseases and its relationship with disease activities.

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Immunoglobulin E, Interleukin-18 and Interleukin-12 in Patients with Atopic Dermatitis: Correlation with Disease Activity

Cited by 34 publications

References 30 publications

Systemic and stratum corneum biomarkers of severity in infant atopic dermatitis include markers of innate and T helper cell‐related immunity and angiogenesis

Systemic and stratum corneum biomarkers of severity in infant atopic dermatitis include markers of innate and T helper cell‐related immunity and angiogenesis

Filaggrin, major basic protein and leukotriene B4: Biomarkers for adult patients of bronchial asthma, atopic dermatitis and allergic rhinitis

IL-18 and Cutaneous Inflammatory Diseases

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