Immunoglobulin E response in health and disease beyond allergic disorders

Colas, Luc; Magnan, A.; Brouard, Sophie

doi:10.1111/all.15230

Cited by 30 publications

(28 citation statements)

References 197 publications

(265 reference statements)

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“…IgE can recognize exogenous antigens (Ags), facilitate antigen presentation via FcϵRI, trigger the degranulation of MCs and the release of multiple mediators, and regulate innate and acquired immunity. Several reports have shown that total serum IgE levels are significantly elevated in patients with psoriasis and that IgE + FcϵRI + cells are significantly increased in psoriatic lesions and decrease with the improvement of the disease ( 12 , 13 ). A non-classical IgE response may occur in psoriasis.…”

Section: Mast Cells In Psoriasismentioning

confidence: 99%

Mast cells as important regulators in the development of psoriasis

Zhou

Chen²,

Zhang³

2022

Front. Immunol.

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Psoriasis is a chronic inflammatory immune skin disease mediated by genetic and environmental factors. As a bridge between innate and adaptive immunity, mast cells are involved in the initiation, development, and maintenance of psoriasis by interactions and communication with a variety of cells. The current review describes interactions of mast cells with T cells, Tregs, keratinocytes, adipocytes, and sensory neurons in psoriasis to emphasize the important role of mast cell-centered cell networks in psoriasis.

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Section: Mast Cells In Psoriasismentioning

confidence: 99%

Mast cells as important regulators in the development of psoriasis

Zhou

Chen²,

Zhang³

2022

Front. Immunol.

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“…FCER2 gene is an 11-exon gene located at chromosome 19p13.3, encoding the low-affinity receptor for IgE (CD23) (32). CD23 interacts with IgE with low affinity, playing a dual role in regulating IgE synthesis in activated B lymphocytes and facilitating allergen-specific activation in T lymphocytes (33,34). Previous studies have demonstrated the role of FCER2/CD23 polymorphisms in exacerbations, lung function, regulation of IgE synthesis, and immunotherapy in asthma (35)(36)(37).…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms in the FCER2 gene have associations with asthma and chronic obstructive pulmonary disease

Zheng¹,

Li²,

Liu³

et al. 2023

J Thorac Dis

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Background: Asthma and chronic obstructive pulmonary disease (COPD) are heterogenetic diseases and exhibit many similarities. Dutch hypothesis proposed that these two diseases may have common genetic origins. This study aims to investigate whether asthma and COPD share a common genetic background in Chinese patients. Methods:In this case-control study, single nucleotide polymorphisms (SNPs) were genotyped using SNaPshot. Haplotype disease analysis and haplotype phenotype analysis were applied to assess the relationship between three polymorphisms of the FCER2 gene and the risk of COPD/asthma. Additionally, associations between polymorphisms of the FCER2 gene and phenotypes were analyzed. Results:We detected ten SNPs of seven genes (FCER1A, FCGR2A, FCGR2B, CHI3L1, ADRB2, STAT6, and FCER2) expressed by airway epithelial cells. We detected genotypes and allele distributions in 251 COPD patients, 597 asthma patients, and 632 healthy controls. A significant difference was found in the FCER2 gene (rs28364072) between COPD patients and controls (P=0.009). Significant differences were observed in the genotype and allele distributions of rs1801274 (FCGR2A), rs12368672 (STAT6), and rs2228137 (FCER2) between asthma patients and controls (P=0.004, 0.007 and 0.010, respectively). Notably, polymorphisms of FCER2 gene were associated with the risk of both COPD (P=0.009 for rs28364072) and asthma (P=0.01 for rs2228137). Haplotype analysis revealed that haplotype T-G-T (alleles of rs28364072, rs2228137, and rs3760687, respectively) was significantly associated with a higher risk of asthma [odds ratios (OR) =2.25, 95% confidence interval (CI): 1.26-4.01, P=0.006]. Further analysis showed that the C-A-C haplotype and C-G-T haplotype were associated with increased blood eosinophils in either COPD or asthma patients (P=0.034, and P<0.001, respectively). Moreover, haplotypes C-A-C, C-G-C, and T-G-C showed significant associations with serum IgE levels in asthma patients (P=0.002, 0.041, and 0.004, respectively).Conclusions: Our data suggest that the FCER2 gene might associate with predisposition to asthma and COPD, while FCER2 haplotypes were associated with pulmonary function measurements and blood eosinophils counts in both diseases. Our findings support the common genetic basis for asthma and COPD, suggesting a potential therapeutic target for the two diseases.

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“…Nevertheless, multiple cardiovascular markers were also found to be raised in pediatric AD and they included E-selectin, an endothelial cell adhesion molecule, and several matrix metalloproteinases (MMP), which are proteins engaged in tissue remodelling [32]. Observations show that immunoglobulin E (IgE) may also play a role in cardiovascular homeostasis and disease; nevertheless, this idea is relatively new and poorly understood [33].…”

Section: Cardiovascular Diseasesmentioning

confidence: 99%

Is Atopic Dermatitis Only a Skin Disease?

Mesjasz

Mazurkiewicz-Bełdzińska

Chałubiński

et al. 2023

IJMS

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Atopic dermatitis (AD) is a chronic, pruritic, inflammatory dermatosis that imposes significant patient and population burdens. In addition to the cutaneous signs and symptoms, growing evidence suggests that AD is systemic in nature. Certain diseases can possibly co-occur with AD as a result of coincidental exposure to similar environmental factors. However, it is also suspected that they are linked to the pathogenesis of AD through more complex genetic and immunological mechanisms, but these correlations remain less understood. It is of great need to seek explanations for the higher frequency of the number of cardiovascular, autoimmune, neurological, psychiatric, and metabolic disorders that have been observed in epidemiologic investigations among AD patients. Moreover, analysing the immunology of chronic inflammation and its correction, activation, or suppression may prevent the development of a variety of comorbidities. As comorbid diseases in patients diagnosed with AD may potentially go undetected, physicians should be aware of them.

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Immunoglobulin E response in health and disease beyond allergic disorders

Cited by 30 publications

References 197 publications

Mast cells as important regulators in the development of psoriasis

Mast cells as important regulators in the development of psoriasis

Polymorphisms in the FCER2 gene have associations with asthma and chronic obstructive pulmonary disease

Is Atopic Dermatitis Only a Skin Disease?

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