Immunoglobulin G Subclass Deficiencies in Adult Patients with Chronic Airway Diseases

Kim, Joo Hee; Park, Sunghoon; Hwang, Yong Il; Jang, Seung Hun; Jung, Ki Suck; Sim, Yun Su; Kim, Cheol Hong; Kim, Chang-Hwan; Kim, Dong Gyu

doi:10.3346/jkms.2016.31.10.1560

Cited by 30 publications

(33 citation statements)

References 29 publications

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“…A Korean group reported that amongst adult patients with asthma or COPD, who were found to have an IgG subclass deficiency, nearly 30% also met ≥2 criteria on a screening test of 10 clinical signs of PIDD. This subgroup had significantly higher numbers of hospitalizations (p = 0.012) and exacerbations of asthma or COPD (p < 0.001), and lower FEV1 (p = 0.036) than the group who did not have warning signs of PIDD [17].…”

Section: Pidd and Airway Diseasesmentioning

confidence: 86%

Primary immune deficiency diseases as unrecognized causes of chronic respiratory disease

Berger

Geng

Cameron

et al. 2017

Respiratory Medicine

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Detection of PIDD as a potentially treatable underlying contributor to recurrent/acute exacerbations and morbidity of COPD, and provision of immunoglobulin (Ig) G replacement therapy, when appropriate, may decrease the progression of COPD. Decreasing the severity and rate of exacerbations and admissions should improve the quality of life and longevity of an important subset of patients with COPD, while decreasing costs. Major steps toward achieving these goals include developing a high index of suspicion, more frequent use and appropriate interpretation of screening tests such as quantitative immunoglobulins and vaccine responses, and prompt institution of IgG replacement therapy when antibody deficiency has been diagnosed.

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Section: Pidd and Airway Diseasesmentioning

confidence: 86%

Primary immune deficiency diseases as unrecognized causes of chronic respiratory disease

Berger

Geng

Cameron

et al. 2017

Respiratory Medicine

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“…Higher hyperreactivity correlated with a defect in IgA [80]. A correlation between IgG subclass deficiency and asthma has recently been highlighted [81].…”

Section: Asthma and Copdmentioning

confidence: 97%

The broad spectrum of lung diseases in primary antibody deficiencies

et al. 2018

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Human primary immunodeficiency diseases (PIDs) represent a heterogeneous group of more than 350 disorders. They are rare diseases, but their global incidence is more relevant than generally thought. The underlying defect may involve different branches of the innate and/or adaptive immune response. Thus, the clinical picture may range from severe phenotypes characterised by a broad spectrum of infections to milder infectious phenotypes due to more selective (and frequent) immune defects. Moreover, infections may not be the main clinical features in some PIDs that might present with autoimmunity, auto-inflammation and/or cancer. Primary antibody deficiencies (PADs) represent a small percentage of the known PIDs but they are the most frequently diagnosed, particularly in adulthood. Common variable immunodeficiency (CVID) is the most prevalent symptomatic PAD.PAD patients share a significant susceptibility to respiratory diseases that represent a relevant cause of morbidity and mortality. Pulmonary complications include acute and chronic infection-related diseases, such as pneumonia and bronchiectasis. They also include immune-mediated interstitial lung diseases, such as granulomatous-lymphocytic interstitial lung disease (GLILD) and cancer. Herein we will discuss the main pulmonary manifestations of PADs, the associated functional and imaging findings, and the relevant role of pulmonologists and chest radiologists in diagnosis and surveillance.

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“…Plebani et al [62] reported that lower respiratory tract infections were most frequent in patients with XLA and that 78% of patients had bronchitis. In milder forms of humoral immunodeficiency, recurrent bronchitis manifests in IgG3 deficiency, the most common subclass deficiency (88.1%), and IgG4 deficiency (15.3%) [63]. IgG subclass deficiency is characterized by exacerbation-prone phenotypes, decline in lung function, and subsequent poor prognosis [63].…”

Section: Bronchitismentioning

confidence: 99%

“…In milder forms of humoral immunodeficiency, recurrent bronchitis manifests in IgG3 deficiency, the most common subclass deficiency (88.1%), and IgG4 deficiency (15.3%) [63]. IgG subclass deficiency is characterized by exacerbation-prone phenotypes, decline in lung function, and subsequent poor prognosis [63]. Although these patients did not manifest evidence of pneumonic infiltration on chest x-ray, they were diagnosed as having recurrent bronchitis, which was defined as ≥3 episodes of acute bronchitis per year [63].…”

Section: Bronchitismentioning

confidence: 99%

“…IgG subclass deficiency is characterized by exacerbation-prone phenotypes, decline in lung function, and subsequent poor prognosis [63]. Although these patients did not manifest evidence of pneumonic infiltration on chest x-ray, they were diagnosed as having recurrent bronchitis, which was defined as ≥3 episodes of acute bronchitis per year [63]. In North American and European studies, antibiotic treatment has not been shown to benefit patients with acute bronchitis, and antibiotic treatment is not recommended for this condition in immunocompetent or immunocompromised patients in developed countries [64].…”

Section: Bronchitismentioning

confidence: 99%

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Infectious and Noninfectious Pulmonary Complications in Patients With Primary Immunodeficiency Disorders

Yazdani

Abolhassani

et al. 2017

J Investig Allergol Clin Immunol

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Primary immunodeficiency disorders (PIDs) are caused by 1 or more defects of the immune system. Patients are more likely to experience recurrent and/or severe infections and tend to develop a wide range of complications. Respiratory diseases are the main and initial manifestation in most cases and the most common complication. Pulmonary complications cause significant morbidity and mortality in patients with PIDs. Early diagnosis and appropriate treatment can prevent or at least slow the development of respiratory complications. Since the spectrum of pulmonary complications in PIDs is broad, we divided pulmonary complications into upper respiratory complications (eg, sinusitis, otitis media, and laryngeal angioedema) and lower respiratory complications (eg, pneumonia, bronchitis, bronchiectasis, interstitial lung diseases, organizing pneumonia, pulmonary adenopathies and malignancies, hyperreactive airway diseases, pulmonary dysgenesis, and adverse reactions to treatment). This review covers the main respiratory manifestations in patients with PIDs. Key words: Primary immunodeficiency disorders. Pulmonary complications. Upper respiratory tract. Lower respiratory tract. ResumenLas inmunodeficiencias primarias (PIDs) son enfermedades causadas por uno o más defectos del sistema inmunológico. Estos pacientes presentan con frecuencia infecciones recidivantes y/o severas así como otro tipo de complicaciones. Las patologías respiratorias son la principal y más frecuente manifestación y complicación de las PIDs. Las complicaciones de estas patologías pulmonares constituyen una de las principales causas de morbimortalidad entre los pacientes que sufren PIDs. El diagnóstico temprano y el tratamiento adecuado pueden prevenir, o al menos retrasar, la aparición de las complicaciones respiratorias en estos pacientes. Dado que el espectro de las enfermedades pulmonares es muy amplio, hemos dividido estas complicaciones entre aquellas que afectan a las vías aéreas superiores (sinusitis, otitis media y angioedema laríngeo, etc.) y las que afectan a las vías aéreas bajas (neumonía, bronquitis, bronquiectasias, enfermedades pulmonares intersticiales, neumonía organizada, adenopatías pulmonares y neoplasias, hiperreactividad bronquial, disgenesia pulmonar y las debidas a los efectos secundarios del tratamiento instaurado). Este artículo revisa las manifestaciones respiratorias que se observan más frecuentemente en los pacientes con PIDs. Palabras clave: Inmunodeficiencias primarias. Complicaciones pulmonares. Vías respiratorias altas. Vías respiratorias bajas.

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Immunoglobulin G Subclass Deficiencies in Adult Patients with Chronic Airway Diseases

Cited by 30 publications

References 29 publications

Primary immune deficiency diseases as unrecognized causes of chronic respiratory disease

Primary immune deficiency diseases as unrecognized causes of chronic respiratory disease

The broad spectrum of lung diseases in primary antibody deficiencies

Infectious and Noninfectious Pulmonary Complications in Patients With Primary Immunodeficiency Disorders

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