Immunoglobulin G Subclass Proteins in Serum and Lavage Fluid of Normal Subjects

Merrill, William; Naegel, Gary P.; Olchowski, J; Reynolds, Herbert Y.

doi:10.1164/arrd.1985.131.4.584

Cited by 116 publications

(34 citation statements)

References 17 publications

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“…The reduced RCE for IgG, which is mainly of plasma origin (Jonard et al, 1984), was not due to abnormal jejunal vascular or epithelial permeability, since jejunal clearance of Alb and the RCE of orosomucoid which is also passively transported from plasma to jejunal lumen (Jonard et al, 1984) did not change. It might be the consequence of an altered pattern of serum IgG subclass distribution, since it is well known that these subclasses differ in their physical properties (Burton, Gregory & Jefferies 1986) which in turn could affect their seepage in external fluids as during bronchoalveolar lavage (Merril et al, 1985). It is noteworthy that raised levels of IgGl and reduced levesl of IgG2 have been reported in the serum of UC patients (Shakib 1976;MacDermott et al, 1988), and that the diseased colon contains less IgG2-synthesizing plasma cells in UC, compared with CD .…”

Section: Discussionmentioning

confidence: 99%

Immunological study of histologically non-involved jejunum during Crohn's disease: evidence for reduced in vivo secretion of secretory IgA

Marteau

Colombel

Németh

et al. 1990

Clinical and Experimental Immunology

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SUMMARYWe studied the local humoral immunity of histologically non-involved jejunum in patients with Crohn's disease. Normal subjects and patients with uleerative colitis served as eontrols. Jejunal fiuid samples were collected during segmental jejunal perfusion, under an occluding balloon and the in vivo jejunal secretion of the following proteins was determined: albumin, orosomucoid, transferrin, a2-macroglobulin, secretory component, monomeric and polymeric IgA, IgG, and IgM. The densities and number of IgA-, IgG-, and IgM-containing cells in the lamina propria of the jejunum were measured on perendoscopic biopsies. Jejunal secretion of polymeric IgA and the density of IgAcontaining plasma cells in the lamina propria were significantly lower in patients with Crohn's disease than in both control groups. This abnormal intestinal immune response, which was not correlated to the activity of the disease, might be involved in its pathogenesis.

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Section: Discussionmentioning

confidence: 99%

Immunological study of histologically non-involved jejunum during Crohn's disease: evidence for reduced in vivo secretion of secretory IgA

Marteau

Colombel

Németh

et al. 1990

Clinical and Experimental Immunology

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“…When women become unable to work on their farm they turn to indoor household work, thus totally avoiding farm dust exposure. The effect of smoking on immunological responses, on the other hand, is still very poorly defined, although some evidence suggests it to be of suppressive nature [17]. Increases in antibody titres were more common in the age groups with most eflicient working capacity.…”

Section: Discussionmentioning

confidence: 99%

Significance of IgG antibodies against environmental microbial antigens in a farming population

Katila

Ojanen

Mäntyjärvi

1986

Clin Experimental Allergy

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Summary A group of dairy farmers studied 6 years earlier in a field survey was re‐surveyed for respiratory symptoms, occupational capability and the presence of antibodies against environmental micro‐organisms. Specific IgG antibodies to Micropolyspora faeni, Thermoactinomyces vulgaris, Aspergillus umbrosus and Aspergillus fumigatus were measured by ELISA from the serum samples obtained in the two surveys. Antibody titres remained constant in 70% of both farmers and controls, but where changes took place, the titres against the actinomycete antigens tended to rise, whereas both increases and decreases were detected equally against the Aspergillus antigens. The titre of specific antibody to any of the four micro‐organisms, when measured from a single serum specimen, seemed to be of little diagnostic value. Observed changes however, were more diagnostic, in that a fall in titre, especially against the Aspergillus antigens, was closely associated with a definite decrease in exposure, such as after retirement. Increased titres occurred in farmers with continued exposure, and those against the actinomycetes were associated with the appearance of symptoms in previously symptom‐free individuals. In a case of farmer's lung which developed in this population during the follow‐up period, significant increases were detectable against T. vulgaris and M. faeni.

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“…Merrill et at. [22] found that in BALF from normal persons the relative concentrations of IgGl and IgG2 were equal to those in serum. The relative concentration of IgG4 was higher in BALF than in serum, suggesting increased local production or active secretion of this protein.…”

mentioning

confidence: 88%

“…The relative concentration of IgG4 was higher in BALF than in serum, suggesting increased local production or active secretion of this protein. IgG3 in BALF was found to be variable [22].…”

mentioning

confidence: 94%

IgG Subclasses in Bronchoalveolar Lavage Fluid from Patients with Asthma

et al. 1991

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We have measured Immunoglobulin G (IgG) subclasses in serum and bronchoalveolar lavage fluid (BALF) from 12 non-smoking patients with stable asthma and 9 non-smoking healthy volunteers to obtain information on their possible role in local immunological reactions. The quotients (concentration of IgG subclass in BALF)/(concentration of IgG subclass in serum) were calculated. In controls QIgG3 were lower than QIgG1, QIgG2 and QIgG4. The IgG subclasses in BALF and epithelial lining fluid (ELF) from patients with asthma were significantly higher than in controls, mainly due to increased leakage from the blood. Again QIgG3 were lower than Q of other subclasses. In the analysis of local production of IgG, albumin or ceruloplasmin was used as reference protein. Several patients showed a local production or a preferential accumulation of one or more IgG subclasses. We conclude that in healthy persons the IgG subclasses in ELF originate from the systemic circulation by passive permeation. In patients with asthma, the permeability of the respiratory membrane may be increased resulting in increased concentrations of subclasses in lung-lining fluid. In some patients with asthma, an additional local production of IgG subclasses occurs.

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Immunoglobulin G Subclass Proteins in Serum and Lavage Fluid of Normal Subjects

Cited by 116 publications

References 17 publications

Immunological study of histologically non-involved jejunum during Crohn's disease: evidence for reduced in vivo secretion of secretory IgA

Immunological study of histologically non-involved jejunum during Crohn's disease: evidence for reduced in vivo secretion of secretory IgA

Significance of IgG antibodies against environmental microbial antigens in a farming population

IgG Subclasses in Bronchoalveolar Lavage Fluid from Patients with Asthma

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