Immunoglobulin M, more than just an early responder to malaria

Boonyaratanakornkit, Jim; Taylor, Justin J.

doi:10.1111/imcb.12292

Cited by 2 publications

(2 citation statements)

References 10 publications

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“…These results might explain recent data associating the depth and breadth of Plasmodium-specific IgM antibodies with genetic resistance to malaria infection [30], and with the reduced risk of clinical malaria in a cohort of children [31]. Taken together, we are in accordance with other that suggest that IgM antibodies seem to be much more than just an early responder to malaria infection [32], and should be investigated during the development of vaccines.…”

Section: Introductionsupporting

confidence: 91%

Dynamics of IgM and IgG responses to the next generation of engineered Duffy binding protein II immunogen: Strain-specific and strain-transcending immune responses over a nine-year period

et al. 2020

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Background A low proportion of P. vivax-exposed individuals acquire protective strain-transcending neutralizing IgG antibodies that are able to block the interaction between the Duffy binding protein II (DBPII) and its erythrocyte-specific invasion receptor. In a recent study, a novel surface-engineered DBPII-based vaccine termed DEKnull-2, whose antibody response target conserved DBPII epitopes, was able to induce broadly binding-inhibitory IgG antibodies (BIAbs) that inhibit P. vivax reticulocyte invasion. Toward the development of DEKnull-2 as an effective P. vivax blood-stage vaccine, we investigate the relationship between naturally acquired DBPII-specific IgM response and the profile of IgG antibodies/BIAbs activity over time. Methodology/principal findings A nine-year follow-up study was carried-out among long-term P. vivax-exposed Amazonian individuals and included six cross-sectional surveys at periods of high and low malaria transmission. DBPII immune responses associated with either strain-specific (Sal1, natural DBPII variant circulating in the study area) or conserved epitopes (DEKnull-2) were monitored by conventional serology (ELISA-detected IgM and IgG antibodies), with IgG BIAbs activity evaluated by functional assays (in vitro inhibition of DBPII-erythrocyte binding). The results showed a tendency of IgM antibodies toward Sal1-specific response; the profile of Sal1 over DEKnull-2 was not associated with acute malaria and sustained throughout the observation period. The low malaria incidence in two consecutive years allowed us to

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Section: Introductionsupporting

confidence: 91%

Dynamics of IgM and IgG responses to the next generation of engineered Duffy binding protein II immunogen: Strain-specific and strain-transcending immune responses over a nine-year period

et al. 2020

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“…Although IgM may play a role in malaria immunity, such a role is not well defined as of yet ( Pleass et al., 2016 ; Stone and Lund, 2016 ). Recently, IgM antibodies were proposed to have a much greater role than just the early response generally stated in classical immunology books ( Boonyaratanakornkit and Taylor, 2019 ). Memory B cells have recently been shown in experimental models to produce specific IgM against Plasmodium sp.…”

Section: Introductionmentioning

confidence: 99%

IgM antibody responses against Plasmodium antigens in neotropical primates in the Brazilian Atlantic Forest

Assis,

Alvarenga,

Souza

et al. 2023

Front. Cell. Infect. Microbiol.

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IntroductionZoonotic transmission is a challenge for the control and elimination of malaria. It has been recorded in the Atlantic Forest, outside the Amazon which is the endemic region in Brazil. However, only very few studies have assessed the antibody response, especially of IgM antibodies, in Neotropical primates (NP). Therefore, in order to contribute to a better understanding of the immune response in different hosts and facilitate the identification of potential reservoirs, in this study, naturally acquired IgM antibody responses against Plasmodium antigens were evaluated, for the first time, in NP from the Atlantic Forest.MethodsThe study was carried out using 154 NP samples from three different areas of the Atlantic Forest. IgM antibodies against peptides of the circumsporozoite protein (CSP) from different Plasmodium species and different erythrocytic stage antigens were detected by ELISA.ResultsFifty-nine percent of NP had IgM antibodies against at least one CSP peptide and 87% against at least one Plasmodium vivax erythrocytic stage antigen. Levels of antibodies against PvAMA-1 were the highest compared to the other antigens. All families of NP showed IgM antibodies against CSP peptides, and, most strikingly, against erythrocytic stage antigens. Generalized linear models demonstrated that IgM positivity against PvCSP and PvAMA-1 was associated with PCR-detectable blood-stage malaria infection and the host being free-living. Interestingly, animals with IgM against both PvCSP and PvAMA-1 were 4.7 times more likely to be PCR positive than animals that did not have IgM for these two antigens simultaneously.DiscussionIgM antibodies against different Plasmodium spp. antigens are present in NP from the Atlantic Forest. High seroprevalence and antibody levels against blood-stage antigens were observed, which had a significant association with molecular evidence of infection. IgM antibodies against CSP and AMA-1 may be used as a potential marker for the identification of NP infected with Plasmodium, which are reservoirs of malaria in the Brazilian Atlantic Forest.

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Immunoglobulin M, more than just an early responder to malaria

Cited by 2 publications

References 10 publications

Dynamics of IgM and IgG responses to the next generation of engineered Duffy binding protein II immunogen: Strain-specific and strain-transcending immune responses over a nine-year period

Dynamics of IgM and IgG responses to the next generation of engineered Duffy binding protein II immunogen: Strain-specific and strain-transcending immune responses over a nine-year period

IgM antibody responses against Plasmodium antigens in neotropical primates in the Brazilian Atlantic Forest

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