Immunohistochemical examination of proliferative potentials and the expression of cell cycle-related proteins of intracranial chordomas

Matsuno, Akira; Sasaki, Tomio; Nagashima, Tadashi; Matsuura, Reiko; Tanaka, Hideki; Hirakawa, Makoto; Murakami, Mineko; Kirino, Takaaki

doi:10.1016/s0046-8177(97)90181-7

Cited by 57 publications

(31 citation statements)

References 15 publications

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“…They all exhibit physaliphorous cells with an abundance of intracytoplasmic vacuoles and extracellular mucin. 2,6,21,23,24,26,27,37 These histological qualities lend to their iso-to hypointensity on T1-weighted MRI and hyperintensity on T2-weighted MRI. 6,22,23,34,35 However, EP demonstrates no contrast enhancement, unlike chordomas, which usually enhance and are more often located extradurally.…”

Section: Discussionmentioning

confidence: 99%

“…6,22,23,34,35 However, EP demonstrates no contrast enhancement, unlike chordomas, which usually enhance and are more often located extradurally. 3,21,35 These are helpful features in making the distinction between the two lesions. When radiographically evaluating these lesions, we recommend thin-section transverse T2-weighted images of the skull base.…”

Section: Discussionmentioning

confidence: 99%

“…Just like EP, intradural chordomas may have a low MIB-1 index, making it difficult to discern the two based on immunohistochemical means as well. 15,21,25,36 The MRI and CT characteristics may be helpful in distinguishing between the two. Intradural chordomas almost never have an associated stalk, and, unlike EP, they usually enhance with Gd administration.…”

Section: 25mentioning

confidence: 99%

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Giant ecchordosis physaliphora in an adolescent girl

Krisht

Palmer²,

Osborn

et al. 2013

PED

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The authors describe a rare case of giant ecchordosis physaliphora (EP) in a 16-year-old female patient who presented with diplopia. Magnetic resonance imaging of the brain with Gd contrast revealed a 3.0 × 1.7 × 1.8–cm nonenhancing, extraaxial epidural mass along the dorsal aspect of the clivus that was T2 hyperintense and T1 isointense with intermediate signal on diffusion sequences. Resection via a transnasal transsphenoidal approach to the ventral clival wall resulted in a stable tumor size with no evidence of interval growth after 30 months. Although this case features a strictly extradural EP, this tumor more commonly occurs in the subdural space and requires differentiation from intradural chordoma. Unlike EP, intradural chordoma may enhance with Gd contrast, is more likely to be associated with cranial nerve palsies and brainstem symptoms, and will occasionally have an elevated MIB-1 index. In this paper the authors highlight the different possible midline locations for both EP and chordoma, the difficulty in distinguishing between intradural giant EP and intradural chordoma, and the potential occurrence of these lesions in young people despite their typically slow rate of growth, while also underscoring the need for further investigation into the tumors' cytogenetic behavior.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: 25mentioning

confidence: 99%

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Giant ecchordosis physaliphora in an adolescent girl

Krisht

Palmer²,

Osborn

et al. 2013

PED

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“…32 Preliminary observations have linked high proliferative indices to the likelihood of recurrence in patients with intracranial chordomas. 60,61 Currently, it does not seem that the chondroid variety is associated with an increased rate of survival after adjustment for other factors. 32,68 The symptom of diplopia has been shown to be associated with increased survival in multivariate analysis.…”

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confidence: 99%

Skull base chordomas: overview of disease, management options, and outcome

Lanzino¹,

As²,

Mb³

et al. 2001

FOC

103

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Cranial base chordomas are locally invasive tumors that, from a midline, clival location, extend in different directions and display various patterns of skull base invasion. Although histologically benign, their invasive nature makes true “oncological” resection virtually impossible to achieve in most cases, despite modern skull base surgical techniques. Moreover, because of the tumor's location and proximity to critical neural and vascular structures, surgery-related morbidity can be significant when an aggressive resection is undertaken. Cytoreductive surgery assumes a critical role in the management of these lesions. The choice of surgical approach and the extent of resection are dependent on several factors: location and extension of the tumor, the surgeon's philosophy and familiarity with a specific approach, and the patient's preexisting clinical status. Proton-beam radiotherapy seems to be effective as an adjunct to surgery in achieving local tumor control. The timing of radiation therapy, however, remains controversial. Gamma knife surgery has been proposed as an adjunctive therapy, but the limited experience and short follow-up periods do not permit formulation of meaningful conclusions at this time. Recurrences are common, although in a subset of patients prolonged disease-free survival is demonstrated.

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“…histopathological factors affecting the recurrence of intracranial chordomas, we studied the proliferative potential of intracranial chordomas immunohistochemically using antiKi-67 monoclonal antibody, MIB-1 [23]. In addition, we studied the expression of p53 protein of intracranial chordomas immunohistochemically [23].…”

Section: Introductionmentioning

confidence: 99%