Immunohistochemical Expression of Stem Cell Markers Cd44, Cd166 and Aldh1a1 in Non-Neoplastic Polyps of the Colon in Sample of Iraqi Patients

Abstract

The aim of this retrospective study on tissue specimens of benign colorectal polyps is to evaluate the significance of IHC markers CD44, CD 166 and ALDH1A1 expression in non-neoplastic (Juvenile and Hamartomatous)

Cancer Stem Cell Markers in Iraqi Patients with Solid Tumor: Review Article

“…In the study of Nawal et al (34) in colorectal cancer, they found that ALDH was elevated in normal adjacent to mucinous adenocarcinoma (NAMC) as compared to non-adjacent to normal mucinous adenocarcima (NANMC) in all groups and in different ages. While, in the study of Basim et al (51) in seventy cases including benign polyps (juvenile & hamartomous polyps) & benign looking colonic tissue showed that ALDH1A1 are co-localized more in benign tumor glands than healthy looking normal which support the idea that increase the number of stem like cells hyper proliferation may predispose colonic mucosa to subsequent transformation.…”

“…Nawal et al (33) showed in the study the expression levels of CD44, CD133 and ALDH in colorectal cancer revealed convey wide range of different expression of markers related to colorectal carcinoma and IHC study may help in early diagnosis and detection of cancer with more attention to increased rate at younger age groups. On the other hand, in the study of benign colorectal tumor, Nawal et al showed that cancer like stem cell markers include CD44, CD166 and ALDH are co localized more in benign tumor glands as compared to that in normal tissues which backing the concept that increase the number of stem like cells hyper proliferation may predispose colonic mucosa to subsequent transformation (34). Meanwhile, our previous studies in Iraqi patients with solid tumors revealed significantly increased in CD44 expression level in breast cancer (31) and papillary thyroid carcinoma (32).…”