Immunohistochemical studies on the distribution of IL-1 and IL-6 producing cells in the synovial membranes of patients with joint disorders.

Kinoshita, H; Minamitani, Kazuhito; Komiya, Setsuro; Higuchi, Fujio; Yamanaka, Kensuke; Inoue, Akio; Matsuo, Keitaro; Yoshimoto, Kohji; Yokoyama, Mitsuo

doi:10.5035/nishiseisai.39.622

Cited by 1 publication

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“…In addition, OA in experimental models and humans is associated with inflammatory changes ( 5 ). Previous research has demonstrated that IL-6 can increase inflammatory cells and stimulate the proliferation of chondrocytes ( 57 ). In the present study, it was demonstrated that IDN5706 also reduced the levels of MMP-13 and IL-6 in chondrocytes.…”

Section: Discussionmentioning

confidence: 99%

Tetrahydrohyperforin prevents articular cartilage degeneration and affects autophagy in rats with osteoarthritis

et al. 2018

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Osteoarthritis (OA) is a highly prevalent disease, which is associated with extracellular matrix degradation and cell death in articular cartilage. The aim of the present study was to identify whether tetrahydrohyperforin (IDN5706) ameliorates the degeneration of articular cartilage and affects autophagy in OA. The rat model of experimental OA was induced by intra-articular injection of collagenase solution. IDN5706 was administered intragastrically to rats for 6 weeks. Histopathological changes in articular cartilage were examined using hematoxylin and eosin (H&E) and safranin O staining, and Mankin scoring systems. The effect of IDN5706 on autophagy was examined using western blotting. ELISA was performed to detect cartilage inflammation. H&E and safranin O staining, Mankin scores, and electron microscopy indicated that IDN5706 could lessen the degeneration of articular cartilage in OA rats. In addition, western blotting revealed that IDN5706 treatment may activate the suppressed autophagy in OA rats. In conclusion, the present study demonstrated that IDN5706 was able to reduce the severity of experimental OA, alleviate the degeneration of articular cartilage, and affect autophagy in OA model rats.

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Section: Discussionmentioning

confidence: 99%