1987
DOI: 10.1159/000124764
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Immunohistochemical Studies on the Roles of Substance P in the Rat Hypothalamus: Possible Implication in the Hypothalamic-Hypophysial-Gonadal Axis

Abstract: The hypothalamic neurons containing substance P (SP) were examined immunohistochemically in rats with a normal estrous cycle or persistent estrus (PE), in pregnancy and in lactating state. In PE animals, the neurons increased in number 1 week after ovariectomy, but then decreased and disappeared. During pregnancy, there were many SP neurons at an early stage but later they gradually decreased in number and disappeared. Consequently, during lactation no SP neurons were evident. The external layer of the median … Show more

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Cited by 30 publications
(10 citation statements)
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“…Furthermore, this effect appeared to be specific for these areas of the brain and was not evident elsewhere. Similarly, SP mRNA increased in the hypothalamus of post-menopausal compared to pre-menopausal women (Rance & Young 1991), and the content of SP in the ARC has been shown to increase after OVX in the rat (Tsuruo et al 1987). The results of all these studies suggest that downregulation of SP and NKA in hypothalamic neurons may mediate, at least in part, the negative feedback action of gonadal steroids on gonadotropin secretion.…”
Section: Sex Steroid Regulation Of Sp and Nkamentioning
confidence: 96%
“…Furthermore, this effect appeared to be specific for these areas of the brain and was not evident elsewhere. Similarly, SP mRNA increased in the hypothalamus of post-menopausal compared to pre-menopausal women (Rance & Young 1991), and the content of SP in the ARC has been shown to increase after OVX in the rat (Tsuruo et al 1987). The results of all these studies suggest that downregulation of SP and NKA in hypothalamic neurons may mediate, at least in part, the negative feedback action of gonadal steroids on gonadotropin secretion.…”
Section: Sex Steroid Regulation Of Sp and Nkamentioning
confidence: 96%
“…The SP system of the rat ARC shows morphological changes across the estrous cycle, with maximal IR cell numbers detected at proestrus/estrus (129, 130). SP-IR axons originating partly from this nucleus form synaptic contacts with GnRH neurons of the preoptic region (131).…”
Section: Afferent Inputs To Gnrh Cellsmentioning
confidence: 99%
“…1985; Tsuruo, Hisano, Nakanishi et al 1987;Parnet, Lenoir, Palkovits & Kerdelhue, 1990), with the most pronounced variations occurring in the ME. Administration of oestrogen increased the level of preprotachykinin mRNA in the hypothalamus, but had the opposite effect in the anterior pituitary (Brown, Harlan & Krause, 1990).…”
Section: Introductionmentioning
confidence: 99%