Immunohistopathological analysis of immune-complexes related to anti-DNA antibodies in the serum and on the glomerulus in MRL/1 mice.

The skin of New Zealand, MRL and BXSB mice was immunohistopathologically examined in order to study the appearance of skin immunoglobulin (Ig) deposition and its correlation with the occurrence of anti-single-stranded (ss) DNA antibodies in sera. Our studies revealed Ig deposition at the dermoepidermal junction (DEJ) in non-lesional skin and a significant age-related correlation between skin Ig deposition and serum anti-ssDNA antibodies. However, immunofluorescent study of autoimmune mice using anti-ultraviolet-irradiated DNA antiserum failed to demonstrate DNA antigens at the DEJ.

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Pathogenesis of lupus dermatoses in autoimmune mice

Furukawa

Kohno

Ohshio

et al. 1985

Arch Dermatol Res

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Immunohistopathological analysis of immune-complexes related to anti-DNA antibodies in the serum and on the glomerulus in MRL/1 mice.

Cited by 1 publication

References 20 publications

Pathogenesis of lupus dermatoses in autoimmune mice

Pathogenesis of lupus dermatoses in autoimmune mice

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