Immunologic alterations in bronchogenic cancer.Sequential Study

Krant, Melvin J.; Manskopf, Gisbert; Brandrup, C. S.; Madoff, Morton A.

doi:10.1002/1097-0142(196804)21:4<623::aid-cncr2820210414>3.0.co;2-p

Cited by 170 publications

(26 citation statements)

References 18 publications

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“…In evaluating the immunological status of cancer patients, moderate immunosuppression was noted in the presence of relatively confined tumors, and significant impairment of the immune system was found in the advanced stages of cancer [98][99][100][101][102][103]. Although the exact nature of immunodeficiency in these patients is unclear, and the potential involvement of the DC system as a basis for the immunosuppression is controversial, numerous evidence has been presented recently suggesting that DC are deficient and not fully functional in the tumor microenvironment (Table 2).…”

Section: Regulation Of Intratumoral Dendritic Cells By Cytokines Chementioning

confidence: 99%

Intratumoral cytokines/chemokines/growth factors and tumor infiltrating dendritic cells: friends or enemies?

Shurin

Lokshin

Yurkovetsky

et al. 2006

Cancer Metastasis Rev

151

100

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The tumor microenvironment consists of a variable combination of tumor cells, stromal fibroblasts, endothelial cells and infiltrating leukocytes, such as macrophages, T lymphocytes, and dendritic cells. A variety of cytokines, chemokines and growth factors are produced in the local tumor environment by different cells accounting for a complex cell interaction and regulation of differentiation, activation, function and survival of multiple cell types. The interaction between cytokines, chemokines, growth factors and their receptors forms a comprehensive network at the tumor site, which is primary responsible for overall tumor progression and spreading or induction of antitumor immune responses and tumor rejection. Although the general thought is that dendritic cells are among the first cells migrating to the tumor site and recognizing tumor cells for the induction of specific antitumor immunity, the clinical relevance of dendritic cells at the site of the tumor remains a matter of debate regarding their role in the generation of successful antitumor immune responses in human cancers. While several lines of evidence suggest that intratumoral dendritic cells play an important role in antitumor immune responses, understanding the mechanisms of dendritic cell/tumor cell interaction and modulation of activity and function of different dendritic cell subtypes at the tumor site is incomplete. This review is limited to discussing the role of intratumoral cytokine network in the understanding immunobiology of tumor-associated dendritic cells, which seems to possess different regulatory functions at the tumor site.

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Section: Regulation Of Intratumoral Dendritic Cells By Cytokines Chementioning

confidence: 99%

Intratumoral cytokines/chemokines/growth factors and tumor infiltrating dendritic cells: friends or enemies?

Shurin

Lokshin

Yurkovetsky

et al. 2006

Cancer Metastasis Rev

151

100

View full text Add to dashboard Cite

show abstract

“…to dilute solutions containing insulin greatly reduces insulin adsorption. 5 We have used gelatin solutions to mimic the action of serum in insulin radioimmunoassay,8 and in later assays substitution of a commercial 3-5% polygeline solution (polymer of degraded gelatin; Haemaccel, Hoechst-Behringwerke) proved equally effective. It seemed likely that this medium, which is normally used as a plasma substitute, would also be suitable as an insulin carrier solution.s…”

Section: Discussionmentioning

confidence: 99%

Immunopotentiation with levamisole in resectable bronchogenic carcinoma: a double-blind controlled trial; Study Group for Bronchogenic Carcinoma.

1975

BMJ

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and large primary tumours and fewer suspected and proved recurrences and deaths from metastases on levamisole in patients with extended tumours. Distant recurrences tended to be less common with levamisole, whereas the disease-free interval in relapsing patients was almost identical in the two groups.These interim results show that levamisole seems to exert its beneficial effect by preventing immunosuppression due to surgery.

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“…3. Unlike the two groups of female rats, the carcinogen fed male rats showed a slightly better antibody response than the (Lytton et al, 1964;Krant et al, 1968), and surgical excision sometimes leads to recovery (Israel et al, 1968).…”

Section: Methodsmentioning

confidence: 99%

The Production of Mammary Carcinomas in Rats by 9,10-Dimethyl-1,2-Benzanthracene and its Relationship to the Oestrous Cycle

Young¹,

Cowan²,

Davidson³

1970

Br J Cancer

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SUMMARY.-Circulating antibody response to flagella antigen has been measured in three groups of Sprague-Dawley rats after feeding with 7.12.DMBA in an attempt to differentiate carcinogen and tumour growth as causative agents in the depression of immune response seen in these animals. DMBA fed female rats developing tumours had progressive depression of both primary and secondary response as compared to control animals, and 7S and 19S antibody fractions were equally affected. Removal of tumours did not result in recovery of response. Attempts to prevent tumour development by mammectomy after DMBA feeding were unsuccessful, but the similar number of tumours found in this group was associated with an equal degree of antibody depression to that seen in the first experiment. Male animals fed DMBA did not develop malignant tumours, and showed no depression of immune response. Results suggest that tumour development plays a part in the depression of circulating antibody response seen in these animals, but that it is not directly related to the number of tumours, and is not reversible by tumour excision.

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Immunologic alterations in bronchogenic cancer.Sequential Study

Cited by 170 publications

References 18 publications

Intratumoral cytokines/chemokines/growth factors and tumor infiltrating dendritic cells: friends or enemies?

Intratumoral cytokines/chemokines/growth factors and tumor infiltrating dendritic cells: friends or enemies?

Immunopotentiation with levamisole in resectable bronchogenic carcinoma: a double-blind controlled trial; Study Group for Bronchogenic Carcinoma.

The Production of Mammary Carcinomas in Rats by 9,10-Dimethyl-1,2-Benzanthracene and its Relationship to the Oestrous Cycle

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