Immunological Checkpoint Blockade in Anal Squamous Cell Carcinoma: Dramatic Responses Tempered By Frequent Resistance

Jayakrishnan, Thejus; Yadav, Devvrat; Huffman, Brandon M.; Cleary, James M.

doi:10.1007/s11912-024-01564-z

Curr Oncol Rep

2024

DOI: 10.1007/s11912-024-01564-z

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Immunological Checkpoint Blockade in Anal Squamous Cell Carcinoma: Dramatic Responses Tempered By Frequent Resistance

Thejus Jayakrishnan,

Devvrat Yadav,

Brandon M. Huffman

et al.

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HPV and Penile Cancer: Epidemiology, Risk Factors, and Clinical Insights

Mannam,

Miller,

Johnson

et al. 2024

Pathogens

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Penile cancer (PC) is a rare malignancy predominantly of squamous cell origin. Approximately 40% of penile tumors are associated with human papillomavirus (HPV) infection. Diagnosing PC remains challenging due to its rarity and variety of clinical presentations. Furthermore, the impact of HPV on the tumor immune microenvironment complicates clinical management, although recent advancements in immune checkpoint inhibitors (ICIs) have shown some efficacy in treating HPV-associated PC. Ongoing research efforts aim to develop oncologic treatments that target HPV-induced cellular modifications. Additionally, novel therapeutic vaccines and adoptive T-cell therapies targeting HPV oncoproteins represent emerging treatment modalities. Our review highlights the complex interplay between HPV and penile carcinogenesis, emphasizing its epidemiology, etiology, clinicopathological characteristics, and potential therapeutic implications.

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HPV and Penile Cancer: Epidemiology, Risk Factors, and Clinical Insights

Mannam,

Miller,

Johnson

et al. 2024

Pathogens

View full text Add to dashboard Cite

show abstract

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Immunological Checkpoint Blockade in Anal Squamous Cell Carcinoma: Dramatic Responses Tempered By Frequent Resistance

Cited by 1 publication

References 65 publications

HPV and Penile Cancer: Epidemiology, Risk Factors, and Clinical Insights

HPV and Penile Cancer: Epidemiology, Risk Factors, and Clinical Insights

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