Abstract:We have used a series of monoclonal antibodies (mAbs) to determine the degree of microscopic structural homology between the retinal Na(+)-Ca2+,K+ and the cardiac Na(+)-Ca2+ exchange proteins. Sets of mAbs were raised separately to partially purified preparations of either the retinal or the recombinant myocardial exchanger. Each panel of mAbs was then screened for crossreactivity with the respective heterologous exchanger using enzyme-linked immunoassay and immunoblotting techniques. Out of 43 anti-retinal ex… Show more
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