Immunological Processes Driving IgE Sensitisation and Disease Development in Males and Females

Leffler, Jonatan; Stumbles, Philip A.; Strickland, Deborah H.

doi:10.3390/ijms19061554

Cited by 42 publications

(42 citation statements)

References 215 publications

(234 reference statements)

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“…We found that people with high level of IgE have a higher risk of KS; however, this relationship is profoundly confounded by sex and HIV. Studies on humans and animal models show that males have higher IgE responses than females after sensitization . Persons with HIV, particularly men, have high level of IgE independently of antiparasitic or allergic responses, and IgE levels correlate with HIV disease progression .…”

Section: Discussionmentioning

confidence: 99%

“…Studies on humans and animal models show that males have higher IgE responses than females after sensitization. 46 Persons with HIV, particularly men, have high level of IgE independently of antiparasitic or allergic responses, and IgE levels correlate with HIV disease progression. 47 Still, in our study, restricting to HIV-uninfected men, levels of IgE were related to KS and higher IgE were associated with higher anti-KSHV antibodies.…”

Section: Ige: a Marker Of Parasitic Exposure Or Immune Dysregulation?mentioning

confidence: 99%

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Mutual detection of Kaposi's sarcoma‐associated herpesvirus and Epstein–Barr virus in blood and saliva of Cameroonians with and without Kaposi's sarcoma

Labò

Marshall

Miley

et al. 2019

Intl Journal of Cancer

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Kaposi's sarcoma‐associated herpesvirus (KSHV) and Epstein–Barr virus (EBV) are prevalent in sub‐Saharan Africa, together with HIV; the consequent burden of disease is grave. The cofactors driving transmission of the two viruses and pathogenesis of associated malignancies are not well understood. We measured KSHV and EBV DNA in whole blood and saliva as well as serum antibodies levels in 175 Cameroonians with Kaposi's sarcoma and 1,002 age‐ and sex‐matched controls with and without HIV. KSHV seroprevalence was very high (81%) in controls, while EBV seroprevalence was 100% overall. KSHV DNA was detectable in the blood of 36–46% of cases and 6–12% of controls; EBV DNA was detected in most participants (72–89%). In saliva, more cases (50–58%) than controls (25–28%) shed KSHV, regardless of HIV infection. EBV shedding was common (75–100%); more HIV+ than HIV− controls shed EBV. Cases had higher KSHV and EBV VL in blood and saliva then controls, only among HIV+ participants. KSHV and EBV VL were also higher in HIV+ than in HIV− controls. Cases (but not controls) were more likely to have detectable KSHV in blood if they also had EBV, whereas shedding of each virus in saliva was independent. While EBV VL in saliva and blood were modestly correlated, no correlation existed for KSHV. Numerous factors, several related to parasitic coinfections, were associated with detection of either virus or with VL. These findings may help better understand the interplay between the two gammaherpesviruses and generally among copathogens contributing to cancer burden in sub‐Saharan Africa.

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Section: Discussionmentioning

confidence: 99%

Section: Ige: a Marker Of Parasitic Exposure Or Immune Dysregulation?mentioning

confidence: 99%

Mutual detection of Kaposi's sarcoma‐associated herpesvirus and Epstein–Barr virus in blood and saliva of Cameroonians with and without Kaposi's sarcoma

Labò

Marshall

Miley

et al. 2019

Intl Journal of Cancer

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“…Studies have shown that sex hormones can affect airway tone and inflammation, and exert effects in different lung cell types, including airway smooth muscle, 121 and immune cells, 48,122,123 although these effects are still under investigation. In the next paragraphs, we discuss the available literature on the effects of sex hormones on the key cell players of lung immunity.…”

Section: Influence Of Sex Hormones In Lung Immune Cellsmentioning

confidence: 99%

Endocrine regulation of lung disease and inflammation

Fuentes

Silveyra

2018

Exp Biol Med (Maywood)

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Sex-based disparities have been identified in respiratory physiology, and in many chronic lung diseases including asthma, chronic obstructive pulmonary disease, and cystic fibrosis. The observed sex differences in lung disease prevalence and incidence have been linked to changes in circulating levels of sex hormones that start after puberty and that have been shown to affect physiological and immunological functions. While the exact roles of male and female sex hormones in these processes have not been fully elucidated, it is now evident that these can target many lung cell types and affect several functions of the respiratory system. In this mini-review, we have summarized seminal studies aimed to understand the effects of the most relevant male and female sex hormones (estrogens, progesterone, and androgens) and their receptors on lung function. Moreover, we have reviewed the known influences of sex hormones and of the hypothalamic–pituitary–gonadal axis in lung disease and immunity. Understanding the roles of sex hormones in the regulation of lung function and inflammation is the first step for the potential development of more effective therapeutic options to prevent and treat lung disease in men and women. Impact statement Sex-differences in the incidence and severity of inflammatory lung diseases have been recognized for years. Women of reproductive age are more likely to suffer from chronic lung disease, with higher mortality rates than men. Physiological changes in hormone levels such as those occurring during the menstrual cycle, pregnancy, and menopause have been associated with lung function changes and asthma symptoms. Despite this, the roles of sex hormones in the mechanisms associated with lung diseases have not been fully elucidated. This review summarizes basic and clinical studies of sex hormones as potential modulators of lung function and inflammation. The information obtained from sex-specific research on lung physiology and pathology will potentially help in the development of sex-specific therapeutics for inflammatory lung disease that may account for the hormonal status of the patient.

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“…Until puberty, they also show a higher prevalence of clinical manifestations, but after puberty females overtake them in the incidence of allergic symptoms. The IgE levels are influenced by the mestrual cycle, suggesting a role of sexual hormones [4]. Female and male differences in allergic responses may be affected by both gender and sex.…”

Section: Introductionmentioning

confidence: 99%

Sex and Gender Aspects for Patient Stratification in Allergy Prevention and Treatment

Martinis

Sirufo

Suppa

et al. 2020

IJMS

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Allergies are rapidly worsening in recent decades, representing the most common immunological diseases. The mechanism of disorders such as asthma, rhinocongiuntivitis, urticaria, atopic dermatitis, food and drug allergies, and anaphylaxis still remain unclear and consequently treatments is mostly still symptomatic and aspecific while developments of new therapies are limited. A growing amount of data in the literature shows us how the prevalence of allergic diseases is different in both sexes and its changes over the course of life. Genes, hormones, environmental and immunological factors affect sex disparities associated with the development and control of allergic diseases, while they more rarely are considered and reported regarding their differences related to social, psychological, cultural, economic, and employment aspects. This review describes the available knowledge on the role of sex and gender in allergies in an attempt to improve the indispensable gender perspective whose potential is still underestimated while it represents a significant turning point in research and the clinic. It will offer insights to stimulate exploration of the many aspects still unknown in this relationship that could ameliorate the preventive, diagnostic, and therapeutic strategies in allergic diseases.

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Immunological Processes Driving IgE Sensitisation and Disease Development in Males and Females

Cited by 42 publications

References 215 publications

Mutual detection of Kaposi's sarcoma‐associated herpesvirus and Epstein–Barr virus in blood and saliva of Cameroonians with and without Kaposi's sarcoma

Mutual detection of Kaposi's sarcoma‐associated herpesvirus and Epstein–Barr virus in blood and saliva of Cameroonians with and without Kaposi's sarcoma

Endocrine regulation of lung disease and inflammation

Sex and Gender Aspects for Patient Stratification in Allergy Prevention and Treatment

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