Immunological responses following the third dose of the BNT162b2 SARS-CoV-2 vaccine among Japanese healthcare workers

Tamura, M.; Fujita, Retsu; Sato, Tomoaki; Sato, Ryohei; Kato, Yasuyuki; Nagasawa, Mitsuaki; Matsumoto, Tetsuya

doi:10.1016/j.jiac.2022.07.006

Cited by 4 publications

(5 citation statements)

References 21 publications

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“…Anti-receptor-binding domain (RBD) antibody titers are known to increase markedly after the booster dose (third dose) of the vaccine [10]. In this study, consistent with previous reports, we have confirmed that the third booster vaccination is effective in increasing the antibody titer, but the boosted antibody titer after the third vaccination also decreased over time.…”

Section: Discussionsupporting

confidence: 92%

Longitudinal Changes in IgG-Type SARS-CoV-2 Antibody Titers after COVID-19 Vaccination and a Prominent Increase in Antibody Titers When Infected after Vaccination

et al. 2023

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Objective: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody titers level and duration of elevated levels are considered important indicators for confirming the efficacy of coronavirus disease 2019 (COVID-19) vaccines. The objective of this study was to demonstrate the changes in antibody titers after the second and third doses of the COVID-19 vaccine, and to determine the antibody titers in cases of spontaneous infection with SARS-CoV-2 after vaccination. Materials and Methods: From June 2021 to February 2023, IgG-type SARS-CoV-2 antibody titers were measured in 127 participants, including 74 outpatients and 53 members of staff, at the Osaka Dental University Hospital (64 males and 63 females, mean age 52.3 ± 19.0 years). Results: Consistent with previous reports, the SARS-CoV-2 antibody titer decreased with time, not only after the second dose but also after the third dose of the vaccine if there was no spontaneous COVID-19 infection. We also confirmed that the third booster vaccination was effective in increasing the antibody titer. A total of 21 cases of natural infections were observed after administering two or more doses of the vaccine. Thirteen of these patients had post-infection antibody titers exceeding 40,000 AU/mL, and some cases continued to maintain antibody titers in the tens of thousands of AU/mL even after more than 6 months had passed since infection. Conclusions: The rise in and duration of antibody titers against SARS-CoV-2 are considered important indicators for confirming the efficacy of novel COVID-19 vaccines. A longitudinal follow-up of antibody titers after vaccination in larger studies is warranted.

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Section: Discussionsupporting

confidence: 92%

Longitudinal Changes in IgG-Type SARS-CoV-2 Antibody Titers after COVID-19 Vaccination and a Prominent Increase in Antibody Titers When Infected after Vaccination

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Anti-RBD antibody titers are known to increase markedly after the booster dose (third dose) of the vaccine (10). In this study, consistent with previous reports, we have confirmed that the third booster vaccination is effective in increasing the antibody titer, but the boosted antibody titer after the third vaccination also decreased over time.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal changes in IgG-type SARS-CoV-2 antibody titers after COVID-19 vaccination and, prominent increase in antibody titers when infected after vaccination

Kusunoki

Ohkusa

Iida

et al. 2023

Preprint

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【Objective】 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody titers level and duration of elevated levels are considered important indicators for confirming the efficacy of coronavirus disease 2019 (COVID-19) vaccines. The objective of this study was to demonstrate the changes in antibody titers after the second and third doses of the COVID-19 vaccine, and to determine the antibody titers in cases of spontaneous infection with SARS-CoV-2 after vaccination. 【Materials and Methods】 From June 2021 to February 2023, IgG-type SARS-CoV-2 antibody titers were measured in 127 participants, including 74 outpatients and 53 staffs, at the Osaka Dental University Hospital (65 males and 62 females, mean age 52.3 years). 【Results】 Consistent with previous reports, the SARS-CoV-2 antibody titer decreased with time, not only after the second dose, but also after the third dose of the vaccine if there is no spontaneous COVID-19 infection. We also confirmed that the third booster vaccination was effective in increasing the antibody titer. Sixteen cases of natural infections were observed after administering two or more doses of the vaccine. Eleven of these patients had post-infection antibody titers exceeding 40,000 AU/mL, and some cases continued to maintain antibody titers in the tens of thousands of AU/mL even after more than 6 months had passed since infection. 【Conclusion】 The rise in and duration of antibody titers against SARS-CoV-2 are considered important indicators for confirming the efficacy of novel COVID-19 vaccines. A longitudinal follow-up of antibody titers after vaccination in larger studies is warranted.

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“…Recent studies on the effectiveness of the third dose of the vaccine found improved efficacy against SARS-CoV-2 infection and a reduction in hospitalization [ [8] , [9] , [10] , [11] , [12] , [13] , [14] ]. However, most studies on the effect of the third vaccination have been limited to a relatively short period of time after the third dose, and few longitudinal analyses of the effects of the third vaccination with an anti–SARS-CoV-2 vaccine have been reported.…”

Section: Introductionmentioning

confidence: 99%

Antibody response to third and fourth BNT162b2 mRNA booster vaccinations in healthcare workers in Tokyo, Japan

Sanada

Honda

Higa

et al. 2023

Journal of Infection and Chemotherapy

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Immunological responses following the third dose of the BNT162b2 SARS-CoV-2 vaccine among Japanese healthcare workers

Cited by 4 publications

References 21 publications

Longitudinal Changes in IgG-Type SARS-CoV-2 Antibody Titers after COVID-19 Vaccination and a Prominent Increase in Antibody Titers When Infected after Vaccination

Longitudinal Changes in IgG-Type SARS-CoV-2 Antibody Titers after COVID-19 Vaccination and a Prominent Increase in Antibody Titers When Infected after Vaccination

Longitudinal changes in IgG-type SARS-CoV-2 antibody titers after COVID-19 vaccination and, prominent increase in antibody titers when infected after vaccination

Antibody response to third and fourth BNT162b2 mRNA booster vaccinations in healthcare workers in Tokyo, Japan

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