Immunological responses in pregnancy.

Brain, Peter; Marston, R. H.; Gordon, J.F.

doi:10.1136/bmj.4.5838.488-a

Cited by 13 publications

(1 citation statement)

References 2 publications

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“…Using a B rosette test, Brain et al [5] found normal B cell counts during pregnancy. Strelkauskas et al [15] deter mined T and B rosette-forming cells simul taneously and found a change (inversion) during pregnancy with low T/B ratio first in pregnancy and a normal ratio at term.…”

Section: Discussionmentioning

confidence: 99%

Cell-Mediated Immunity in Pregnancy Evaluated Using Lymphocyte Transformation Tests and Rosette Tests for T and B Lymphocytes

Birkeland¹,

Kristoffersen²

1978

Int Arch Allergy Immunol

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In vitro tests of cellular immune response using lymphocyte transformation tests and rosette tests for T and B lymphocytes were studied in a cross-section analysis of a total of 55 patients in six groups (non-pregnant, 2–3 month pregnant, 4–5 month pregnant, 6–7 month pregnant, at parturition and 3 months after parturition). No pregnancy-related changes were found in the numbers of T, B or nil cells, nor changes in PHA, PWM or MLC responses. However, a significant reversible depression of the PPD response was found in the second half of pregnancy.

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Section: Discussionmentioning

confidence: 99%

Cell-Mediated Immunity in Pregnancy Evaluated Using Lymphocyte Transformation Tests and Rosette Tests for T and B Lymphocytes

Birkeland¹,

Kristoffersen²

1978

Int Arch Allergy Immunol

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Electrophoretic mobilities and levels of T and B lymphocytes in human pregnancy

et al. 1984

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Automatic cell electrophoresis has been used to investigate electrokinetic properties and the levels of T and B lymphocytes in peripheral blood of 124 pregnant women at different stages of gestation, and in 44 healthy controls. The electrophoretic mobilities (EPM) of T and B lymphocytes in maternal peripheral blood vary only slightly throughout pregnancy. In the pregnant subjects, there is a small but significant reduction in the percentage of circulating T lymphocytes. It is concluded that an increased electrostatic repulsion between maternal lymphocytes and trophoblast cells by alterations in the surface charge of lymphocytes plays an unimportant role in protecting the allogenic fetus from maternal immune attack.

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