2011
DOI: 10.1016/j.vaccine.2011.09.013
|View full text |Cite
|
Sign up to set email alerts
|

Immunological solutions for treatment and prevention of porcine reproductive and respiratory syndrome (PRRS)

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2

Citation Types

12
196
1

Year Published

2012
2012
2024
2024

Publication Types

Select...
6
2
1

Relationship

0
9

Authors

Journals

citations
Cited by 196 publications
(209 citation statements)
references
References 150 publications
12
196
1
Order By: Relevance
“…Therefore, neutralizing antibodies might not be required for resolution of viremia in vAJXM infection. In fact, previous studies have demonstrated that PRRSV viremia is often resolved before neutralizing antibodies are detected (12,31,33). No antibodies and viremia were detected in serum samples from vJGP5N35/44/51S-infected pigs throughout the observation period.…”
Section: Virusmentioning
confidence: 83%
See 1 more Smart Citation
“…Therefore, neutralizing antibodies might not be required for resolution of viremia in vAJXM infection. In fact, previous studies have demonstrated that PRRSV viremia is often resolved before neutralizing antibodies are detected (12,31,33). No antibodies and viremia were detected in serum samples from vJGP5N35/44/51S-infected pigs throughout the observation period.…”
Section: Virusmentioning
confidence: 83%
“…In addition, hypoglycosylated PRRSV mutants were more sensitive to serum samples collected from vAJXM-or vJGP5N44K-infected piglets, suggesting that the integrated glycosylation in GP5 contributed more resistance to neutralization (2,17). However, the role of neutralizing antibodies to GP5 in anti-PRRSV immunity is elusive (26,31). Genetic experiments showed that GP5 was not required for macrophage permissiveness and that complexes of minor envelope proteins GP2, GP3, and GP4 were essential for infection of permissive cells (13,39,48).…”
Section: Virusmentioning
confidence: 99%
“…Even though modified live virus (MLV) vaccines were shown to provide solid protection against PRRSV infection, there were substantial barriers to the use of MLV vaccines in the field (2,5). Considering the extensive use of MLV vaccines for preventing and controlling PRRS in mainland China, the appearance of a natural recombination event between a vaccine strain and a field strain is noteworthy.…”
mentioning
confidence: 99%
“…HP-PRRSV is the etiological agent of HP-PRRS epidemics, which first emerged in southern China in 2006; the virus is currently widespread in China and several Southeast Asian countries, causing enormous economic losses (1,3,6,9,12). Live attenuated PRRSV vaccines based on serial in vitro passage are efficient tools that can be used to protect pigs against PRRSV infection (8,13). However, little is known about the genomic characteristics of the overattenuated PRRSV.…”
mentioning
confidence: 99%