Immunological Study on Circulating Murine Osteoprotegerin/Osteoclastogenesis Inhibitory Factor (OPG/OCIF): Possible Role of OPG/OCIF in the Prevention of Osteoporosis in Pregnancy

Osteoprotegerin in Human Milk: A Potential Role in the Regulation of Bone Metabolism and Immune Development

“…To date, the cellular source of circulating OPG is not known, and the mechanisms that regulate the levels in serum have not been described. Nevertheless, it has been reported that the concentration of circulating OPG markedly increases in the mouse during pregnancy and that it may serve to protect against excess bone resorption prepartum (27). Recently, a study in humans also showed that the concentrations of serum OPG in mothers steadily increases during pregnancy.…”

Osteoprotegerin, Rank, Rankl

“…It is probable that in the above-mentioned cases the OPG concentrations are increased, but OPG/ RANKL ratio is decreased and increased, respectively 2,31 . Only few human clinical studies proved correlation between OPG and bone density but other studies did not find any correlation 2,18,31 . No unambiguous associations were proved between OPG concentration and occurrence of osteoporotic fractures or risk of their origin (only one ad hoc performed analysis of several women with collum fractures reported a possible correlation between OPG and risk of their occurrence) 2 .…”

“…Another possible cause of enhanced OPG level could be the OPG binding on RANKL and subsequently a reduced OPG clearance 2 . The experimental animal models showed that OPG concentration enhanced considerably during pregnancy (a protective role could be supposed in the prevention of osteoporosis in pregnant women) 18 . OPG increases in patients with severe renal failure; preliminary results indicate that this is due to OPG clearance (immediately after renal transplantation the OPG levels decrease) 20 .…”

Gebelik ile ilişkili Osteoporoz

“…Osteoklastların potent bir inhibitörü olup gebelikte artar ve anneden fetüse kalsiyum geçişini sınırlar, bu sayede maternal iskeletin korunmasında önemli rol oynar (18).…”

“…Bu nedenle uzun süreli laktasyon, annede daha fazla kemik kaybına sebep olur (18). Buna paralel olarak laktasyon süreci biter bitmez tekrar gebe kalan kadınlarda KMY kaybı, gebelik dönemleri arasında uzun süre olan kadınlara göre daha belirgindir (20).…”