Immunological Tolerance within the ABO Blood Group System*

Jakobowicz, Rachel; Crawford, Hal; Graydon, J. J.; Pinder, Marjorie

doi:10.1111/j.1365-2141.1959.tb04031.x

Cited by 26 publications

(8 citation statements)

References 5 publications

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“…These re sults, therefore, are in agreement with several reports in the literature [5,7,8,9,10] but disagree with the conclusions of Jakobowicz et al [6], who stated that 'both before and after the injection of tetanus toxoid the mean anti-A titers were significantly lower in type-O sons of A mothers than in O sons of O mothers at the p=0.05 level'. Their data, however, contain also information which contradicts the existence of immunologic tolerance.…”

Section: Discussioncontrasting

confidence: 47%

“…In the literature, one report [6] claims the existence of partial tolerance to the A antigen while sever al studies [5,7,8,9,10] did not reveal any difference between group-O children born to group-O mothers and children born to group-A moth ers. Very little information has previously been reported on partial toler ance to anti-B, evidently because of the low frequency of group-B indi viduals in Western populations.…”

mentioning

confidence: 99%

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Partial Immunologic Tolerance to the Human B but not to the A Antigen

Grundbacher¹,

Shreffler²

1972

Int Arch Allergy Immunol

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Quantitation of anti-A and anti-B isoantibodies in 472 selected children of the Tecumseh population has provided strong evidence that the A antigen of the mother does not induce any immunologic tolerance in her group-O children. Mean levels of hemolytic and saline anti-B, on the other hand, were lower in children of mothers with the B antigen than in children of mothers who lacked B, thus, indicating that the B antigen of the mother induces partial immunologic tolerance in her children.

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Section: Discussioncontrasting

confidence: 47%

mentioning

confidence: 99%

Partial Immunologic Tolerance to the Human B but not to the A Antigen

Grundbacher¹,

Shreffler²

1972

Int Arch Allergy Immunol

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“…A number of studies in healthy volunteers have shown an association between vaccina tions and increases of anti-A and anti-B titres [3,8,11,13,14]. However, no such studies have been done during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

“…This paper reports the findings of such a study. A number of reports [3,8,11,13,14] have established that some vaccines can in crease anti-A and anti-B iso-agglutinin titres. It is possible that this will increase the risk of haemolytic disease of the new-born (HDN) in ABO-incompatible pregnancies.…”

Section: Introductionmentioning

confidence: 99%

Increased Incidence of Haemolytic Disease of the New-Born Caused by ABO-Incompatibility when Tetanus Toxoid is Given during Pregnancy

Gupte¹,

Bhatia²

1980

Vox Sanguinis

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To determine whether tetanus toxoid given during pregnancy increases the risk of haemolytic disease of the new-born, 818 group 0 pregnant women were given one to three doses of tetanus toxoid during the third trimester. There was a significant increase in the incidence of neonatal jaundice among the AB0-incompatible infants of women given toxoid, compared to a control group. Comparative studies were also done at two hospitals: tetanus toxoid was not given during pregnancy at one hospital and was used routinely at the other. More of the mothers given toxoid had high titres of igG anti-A or anti-B and more of their AB0-incompatible infants became jaundiced. Thus these studies suggest an increased risk of haemolytic disease of the new-born due to AB0 incompatibility when tetanus toxoid injections are given during pregnancy.

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“…However, Mayeda [8] found that the "self marker concept" is not applicable to the Rh blood group system. Jakobowicz, Crawford, Graydon and Pinder [6,7] found that the concept is applicable to the ABO blood group system. However, Tiilikainen, Lehtovaara and Ericksson [12] and Wichler and Wozniczko-Orlowsica [14] were unable to show any correlation between the mother's ABO blood group and the offspring's anti-A and/or anti-B antibody titers.…”

mentioning

confidence: 99%

Study of Tolerance to the ABO Blood Group Antigens

Mayeda¹

1966

Vox Sanguinis

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Immunological Tolerance within the ABO Blood Group System*

Cited by 26 publications

References 5 publications

Partial Immunologic Tolerance to the Human B but not to the A Antigen

Partial Immunologic Tolerance to the Human B but not to the A Antigen

Increased Incidence of Haemolytic Disease of the New-Born Caused by ABO-Incompatibility when Tetanus Toxoid is Given during Pregnancy

Study of Tolerance to the ABO Blood Group Antigens

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