Immunologically mediated abortion (IMA)

Giacomucci, E; Bulletti, Carlo; Polli, V.; Prefetto, R. A.; Flamigni, Carlo

doi:10.1016/0960-0760(94)90001-9

Cited by 15 publications

(5 citation statements)

References 78 publications

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“…All of them had 2 or more abortions before the surgical intervention. All patients had received genetics endocrine metabolic screening and a complete screening for RSA as previously reported [2,4]. …”

Section: Methodsmentioning

confidence: 99%

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Term Delivery Rate after Hysteroscopic Metroplasty in Patients with Recurrent Spontaneous Abortion and T-Shaped, Arcuate and Septate Uterus

Giacomucci

Bellavia

Fabrizio

et al. 2010

Gynecol Obstet Invest

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Background: To evaluate the improvement of the term delivery rate after uterine surgery in various uterine malformations. Methods: 170 patients were eligible for the present retrospective case series study. Data were weighted for the number of pregnancies observed (n = 218) after surgical intervention, stratified to the number of previous abortions (at least 2) and type of malformation. Results: Before surgery, the overall term delivery rate was 5.5%. After surgery, the overall term delivery rate was 59% (absolute benefit increase, ABI, was 54.5) and correlated with the number of previous abortions (69.7% ABI = 64.2, 56.5% ABI = 51 and 26.3% ABI = 20.8 for 2, 3–4 and >4 abortions, respectively; p = 0.0008, log-rank test). Data stratified according to uterine malformations yielded the following term delivery rate: 66.7% for T-shaped uterus, 62.8% for septum/partial septum and 55.6% for arcuate uterus (NS, log-rank test). The number of previous abortions and maternal age also affected the term delivery rate. Their effect upon the term delivery rate, expressed as an odds ratio, was 1.73 (95% CI: 1.20–2.49) and 1.11 (95% CI: 1.05–1.18), respectively. Conclusion: The term delivery rate was about 10-fold higher after surgery. T-shaped uterus surgery yielded the best term delivery rate.

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Section: Methodsmentioning

confidence: 99%

“…They may be associated with recurrent pregnancy loss, preterm labor and infertility [1,2,3,4]. The classification of mullerian anatomic uterine defects was proposed by the American Fertility Society (AFS) [5].…”

Section: Introductionmentioning

confidence: 99%

Term Delivery Rate after Hysteroscopic Metroplasty in Patients with Recurrent Spontaneous Abortion and T-Shaped, Arcuate and Septate Uterus

Giacomucci

Bellavia

Fabrizio

et al. 2010

Gynecol Obstet Invest

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“…Additionally, there is still no consensus on the relationship between RPL and ACA, EmAb, ATA. 7,8 The main goal of this study was to retrospectively explore the changes in coagulation indexes, thromboelastogram parameters and autoantibodies in RSA patients with different number of abortions to better understand a possible mechanism of RPL.…”

Section: Original Articlementioning

confidence: 99%

Analysis of blood coagulation indexes, thromboelastogram and autoantibodies in patients with recurrent pregnancy loss

Yao¹,

Ji²,

Zhou

2022

Pak J Med Sci

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Objectives: Changes in coagulation indexes, thromboelastogram(TEG) and autoantibodies in patients with recurrent pregnancy loss (RPL) with different number of abortions were analyzed. Methods: Medical records of 48 patients with recurrent abortion, treated in Quzhou people’s Hospital from November 2019 to October 2020, were collected as the observation group. Based on the number of abortions, patients were divided into Group-A (Two abortions, n=21), Group-B (Three abortions, n=16) and group C (Abortion ≥ four times, n=11). Records of 50 healthy pregnant women in our hospital in the same period were selected as the control group. Coagulation indexes [prothrombin time (PT), activated partial prothrombin time (APTT), fibrinogen (FIB), D-Dimer (DD)], thromboelastogram (TEG) parameters [reaction time (R), coagulation time(K), maximum thrombus amplitude (MA), coagulation angle (α)], changes in the levels of autoantibodies [anticardiolipin antibody (ACA), anti-endometrial antibody (EmAb), anti-thyroid antibody(ATA)] were compared between the groups. Results: There were significant differences in the levels of ATPP, Pt, FIB and DD among the groups. Higher number of abortions correlated with lower the levels of ATPP and Pt, and higher levels of FIB and DD (P<0.05). Compared to the control group, R and K in Group-A,B and C decreased, while α and MA increased (P<0.05). There were significant differences in α and MA indexes. The positive rates of ACA, EmAb and ATA in Group-A were higher than those in the control group, but the difference was not statistically significant (P>0.05), while the above indexes in groups B and C were significantly higher than those in the control group(P<0.05). The positive rates of ACA and ATA in group C were significantly higher than those in Group-A(P<0.05), but there was no significant difference in the positive rate of EmAb (P>0.05). Conclusion: RPL was related to the decrease of APTT, PT, and the increase of FIB and DD levels. TEG indicated that the increase of α and MA values indicated that the risk of multiple abortion was increased. The positive rates of ACA, EmAb and ATA were closely related to multiple abortions, especially the positive rates of ACA and ATA. doi: https://doi.org/10.12669/pjms.38.7.6284 How to cite this:Yao H, Ji Y, Zhou Y. Analysis of blood coagulation indexes, thromboelastogram and autoantibodies in patients with recurrent pregnancy loss. Pak J Med Sci. 2022;38(7):2005-2010. doi: https://doi.org/10.12669/pjms.38.7.6284 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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“…About 10-15% of pregnancies diagnosed by ultrasound result in spontaneous abortion [1][2][3]. The vast majority of abortions occur before 8 weeks and the outcome of future pregnancies is considered to be favorable [4].…”

Section: Introductionmentioning

confidence: 99%

Misoprostol treatment for early pregnancy failure does not impair future fertility

Bord

Gdalevich

Nahum

et al. 2014

Gynecological Endocrinology

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Immunologically mediated abortion (IMA)

Cited by 15 publications

References 78 publications

Term Delivery Rate after Hysteroscopic Metroplasty in Patients with Recurrent Spontaneous Abortion and T-Shaped, Arcuate and Septate Uterus

Term Delivery Rate after Hysteroscopic Metroplasty in Patients with Recurrent Spontaneous Abortion and T-Shaped, Arcuate and Septate Uterus

Analysis of blood coagulation indexes, thromboelastogram and autoantibodies in patients with recurrent pregnancy loss

Misoprostol treatment for early pregnancy failure does not impair future fertility

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